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The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.

Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC.

Mol Carcinog. 2009 Nov;48(11):1048-58. doi: 10.1002/mc.20557.


Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells.

Cetinkaya C, Hultquist A, Su Y, Wu S, Bahram F, Påhlman S, Guzhova I, Larsson LG.

Mol Cancer Ther. 2007 Oct;6(10):2634-41.


Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

Zhu J, Blenis J, Yuan J.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6584-9. doi: 10.1073/pnas.0802785105. Epub 2008 May 1.


Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

Xu D, Popov N, Hou M, Wang Q, Björkholm M, Gruber A, Menkel AR, Henriksson M.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3826-31.


Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase.

Ge Z, Li W, Wang N, Liu C, Zhu Q, Björkholm M, Gruber A, Xu D.

FASEB J. 2010 Feb;24(2):579-86. doi: 10.1096/fj.09-140087. Epub 2009 Sep 17.


Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene.

Rottmann S, Speckgens S, Lüscher-Firzlaff J, Lüscher B.

FASEB J. 2008 Apr;22(4):1124-34. Epub 2007 Nov 12.


PinX1 inhibits telomerase activity in gastric cancer cells through Mad1/c-Myc pathway.

Wang HB, Wang XW, Zhou G, Wang WQ, Sun YG, Yang SM, Fang DC.

J Gastrointest Surg. 2010 Aug;14(8):1227-34. doi: 10.1007/s11605-010-1253-4. Epub 2010 Jun 11.


MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation.

Poortinga G, Hannan KM, Snelling H, Walkley CR, Jenkins A, Sharkey K, Wall M, Brandenburger Y, Palatsides M, Pearson RB, McArthur GA, Hannan RD.

EMBO J. 2004 Aug 18;23(16):3325-35. Epub 2004 Jul 29.


Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression.

Delpuech O, Griffiths B, East P, Essafi A, Lam EW, Burgering B, Downward J, Schulze A.

Mol Cell Biol. 2007 Jul;27(13):4917-30. Epub 2007 Apr 23.


Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells.

Moon DO, Kim MO, Lee JD, Choi YH, Kim GY.

Cancer Lett. 2009 Dec 28;286(2):172-9. doi: 10.1016/j.canlet.2009.05.028. Epub 2009 Jun 27.


Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression.

Amente S, Zhang J, Lavadera ML, Lania L, Avvedimento EV, Majello B.

Nucleic Acids Res. 2011 Dec;39(22):9498-507. doi: 10.1093/nar/gkr638. Epub 2011 Aug 10. Erratum in: Nucleic Acids Res. 2014 Feb;42(3):2098.


Mad1 function is regulated through elements within the carboxy terminus.

Barrera-Hernandez G, Cultraro CM, Pianetti S, Segal S.

Mol Cell Biol. 2000 Jun;20(12):4253-64.


Mad 1 inhibits cell growth and proliferation but does not promote differentiation or overall survival in human U-937 monoblasts.

Hultquist A, Cetinkaya C, Wu S, Castell A, Erlandsson A, Larsson LG.

Mol Cancer Res. 2004 Aug;2(8):464-76.


Transcript regulation of human telomerase reverse transcriptase by c-myc and mad1.

Zou L, Zhang PH, Luo CL, Tu ZG.

Acta Biochim Biophys Sin (Shanghai). 2005 Jan;37(1):32-8.


TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity.

Wu S, Hultquist A, Hydbring P, Cetinkaya C, Oberg F, Larsson LG.

Exp Cell Res. 2009 Nov 1;315(18):3099-111. doi: 10.1016/j.yexcr.2009.09.009. Epub 2009 Sep 17.

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