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Items: 1 to 20 of 110

1.

The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity.

Scott GN, DuHadaway J, Pigott E, Ridge N, Prendergast GC, Muller AJ, Mandik-Nayak L.

J Immunol. 2009 Jun 15;182(12):7509-17. doi: 10.4049/jimmunol.0804328.

3.

Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice.

Szántó S, Koreny T, Mikecz K, Glant TT, Szekanecz Z, Varga J.

Arthritis Res Ther. 2007;9(3):R50.

4.

Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.

Rytelewski M, Meilleur CE, Yekta MA, Szabo PA, Garg N, Schell TD, Jevnikar AM, Sharif S, Singh B, Haeryfar SM.

PLoS One. 2014 Feb 28;9(2):e90439. doi: 10.1371/journal.pone.0090439. eCollection 2014.

5.

Influence of tryptophan contained in 1-Methyl-Tryptophan on antimicrobial and immunoregulatory functions of indoleamine 2,3-dioxygenase.

Schmidt SK, Siepmann S, Kuhlmann K, Meyer HE, Metzger S, Pudelko S, Leineweber M, Däubener W.

PLoS One. 2012;7(9):e44797. doi: 10.1371/journal.pone.0044797. Epub 2012 Sep 13.

6.

IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.

Merlo LM, Pigott E, DuHadaway JB, Grabler S, Metz R, Prendergast GC, Mandik-Nayak L.

J Immunol. 2014 Mar 1;192(5):2082-90. doi: 10.4049/jimmunol.1303012. Epub 2014 Jan 31.

7.

Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition.

Zhu L, Ji F, Wang Y, Zhang Y, Liu Q, Zhang JZ, Matsushima K, Cao Q, Zhang Y.

J Immunol. 2006 Dec 1;177(11):8226-33.

8.

Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment.

Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson AB, Roberts AI, Wang Y, Shi Y.

Cancer Res. 2014 Mar 1;74(5):1576-87. doi: 10.1158/0008-5472.CAN-13-1656. Epub 2014 Jan 22.

9.

Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO.

Zhang A, Zheng Y, Que Z, Zhang L, Lin S, Le V, Liu J, Tian J.

J Cancer Res Clin Oncol. 2014 Nov;140(11):1883-90. doi: 10.1007/s00432-014-1744-x. Epub 2014 Jul 1.

PMID:
24980548
10.

IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis.

Yan Y, Zhang GX, Gran B, Fallarino F, Yu S, Li H, Cullimore ML, Rostami A, Xu H.

J Immunol. 2010 Nov 15;185(10):5953-61. doi: 10.4049/jimmunol.1001628. Epub 2010 Oct 13.

11.

Inhibition of indoleamine 2, 3-dioxygenase-mediated tryptophan catabolism accelerates crescentic glomerulonephritis.

Hou W, Li S, Wu Y, Du X, Yuan F.

Clin Exp Immunol. 2009 May;156(2):363-72. doi: 10.1111/j.1365-2249.2009.03902.x. Epub 2009 Mar 11.

12.

IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival.

Sucher R, Fischler K, Oberhuber R, Kronberger I, Margreiter C, Ollinger R, Schneeberger S, Fuchs D, Werner ER, Watschinger K, Zelger B, Tellides G, Pilat N, Pratschke J, Margreiter R, Wekerle T, Brandacher G.

J Immunol. 2012 Jan 1;188(1):37-46. doi: 10.4049/jimmunol.1002777. Epub 2011 Nov 30.

13.

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.

Eleftheriadis T, Pissas G, Antoniadi G, Spanoulis A, Liakopoulos V, Stefanidis I.

Int Immunol. 2014 Dec;26(12):673-84. doi: 10.1093/intimm/dxu077. Epub 2014 Jul 26.

PMID:
25064493
14.

IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive.

Godin-Ethier J, Hanafi LA, Duvignaud JB, Leclerc D, Lapointe R.

Mol Immunol. 2011 Oct;49(1-2):253-9. doi: 10.1016/j.molimm.2011.08.017. Epub 2011 Sep 19.

PMID:
21937116
15.

IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells.

Curran TA, Jalili RB, Farrokhi A, Ghahary A.

Immunobiology. 2014 Jan;219(1):17-24. doi: 10.1016/j.imbio.2013.06.008. Epub 2013 Jun 25.

PMID:
23891282
16.

Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression.

Colvin BL, Sumpter TL, Tokita D, Salati J, Mellor AL, Thomson AW.

Hum Immunol. 2009 May;70(5):313-20. doi: 10.1016/j.humimm.2009.01.021. Epub 2009 Feb 3.

17.

The indoleamine 2,3-dioxygenase inhibitor 1-methyl-tryptophan suppresses mitochondrial function, induces aerobic glycolysis and decreases interleukin-10 production in human lymphocytes.

Eleftheriadis T, Pissas G, Karioti A, Antoniadi G, Liakopoulos V, Dafopoulou K, Pournaras S, Koukoulis G, Stefanidis I.

Immunol Invest. 2012;41(5):507-20. doi: 10.3109/08820139.2012.682244. Epub 2012 May 17.

PMID:
22594922
18.

Malaria parasite induces tryptophan-related immune suppression in mice.

Tetsutani K, To H, Torii M, Hisaeda H, Himeno K.

Parasitology. 2007 Jul;134(Pt 7):923-30. Epub 2007 Feb 22.

PMID:
17316473
19.

IDO1 plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice.

Takamatsu M, Hirata A, Ohtaki H, Hoshi M, Hatano Y, Tomita H, Kuno T, Saito K, Hara A.

J Immunol. 2013 Sep 15;191(6):3057-64. doi: 10.4049/jimmunol.1203306. Epub 2013 Aug 16.

20.

Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment.

Tanizaki Y, Kobayashi A, Toujima S, Shiro M, Mizoguchi M, Mabuchi Y, Yagi S, Minami S, Takikawa O, Ino K.

Cancer Sci. 2014 Aug;105(8):966-73. doi: 10.1111/cas.12445. Epub 2014 Jun 27.

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