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Results: 1 to 20 of 99

1.

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.

Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC.

Mol Cell. 2009 May 14;34(4):461-72. doi: 10.1016/j.molcel.2009.04.031.

PMID:
19481526
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.

Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC.

J Biol Chem. 2008 Jul 4;283(27):18621-6. doi: 10.1074/jbc.M801451200. Epub 2008 May 8.

PMID:
18467330
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation.

Shen RR, Zhou AY, Kim E, Lim E, Habelhah H, Hahn WC.

Mol Cell Biol. 2012 Dec;32(23):4756-68. doi: 10.1128/MCB.00468-12. Epub 2012 Sep 24.

PMID:
23007157
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC.

Cell Rep. 2013 Mar 28;3(3):724-33. doi: 10.1016/j.celrep.2013.01.031. Epub 2013 Feb 28.

PMID:
23453969
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Increased expression of estrogen receptor α-36 by breast cancer oncogene IKKε promotes growth of ER-negative breast cancer cells.

Li Q, Sun H, Zou J, Ge C, Yu K, Cao Y, Hong Q.

Cell Physiol Biochem. 2013;31(6):833-41. doi: 10.1159/000350101. Epub 2013 Jun 7.

PMID:
23816933
[PubMed - indexed for MEDLINE]
6.

IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer.

Guo JP, Shu SK, Esposito NN, Coppola D, Koomen JM, Cheng JQ.

J Biol Chem. 2010 Feb 5;285(6):3676-84. doi: 10.1074/jbc.M109.078212. Epub 2009 Nov 23.

PMID:
19940156
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

Kovalenko A, Chable-Bessia C, Cantarella G, Israël A, Wallach D, Courtois G.

Nature. 2003 Aug 14;424(6950):801-5.

PMID:
12917691
[PubMed - indexed for MEDLINE]
Free Article
8.

[The IKKε kinase in breast cancer: from oncogenesis to treatment resistance].

Grandvaux N.

Med Sci (Paris). 2011 Jun-Jul;27(6-7):619-25. doi: 10.1051/medsci/2011276014. Epub 2011 Jul 1. French.

PMID:
21718646
[PubMed - indexed for MEDLINE]
Free Article
9.

Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.

Reiley W, Zhang M, Wu X, Granger E, Sun SC.

Mol Cell Biol. 2005 May;25(10):3886-95.

PMID:
15870263
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells.

Eddy SF, Guo S, Demicco EG, Romieu-Mourez R, Landesman-Bollag E, Seldin DC, Sonenshein GE.

Cancer Res. 2005 Dec 15;65(24):11375-83.

PMID:
16357145
[PubMed - indexed for MEDLINE]
Free Article
11.

Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells.

Qin B, Cheng K.

Breast Cancer Res. 2010;12(5):R74. doi: 10.1186/bcr2644. Epub 2010 Sep 23.

PMID:
20863366
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death.

Renner F, Moreno R, Schmitz ML.

Mol Cell. 2010 Feb 26;37(4):503-15. doi: 10.1016/j.molcel.2010.01.018.

PMID:
20188669
[PubMed - indexed for MEDLINE]
Free Article
13.

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.

Harris J, Olière S, Sharma S, Sun Q, Lin R, Hiscott J, Grandvaux N.

J Immunol. 2006 Aug 15;177(4):2527-35.

PMID:
16888014
[PubMed - indexed for MEDLINE]
Free Article
14.

Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.

Hutti JE, Porter MA, Cheely AW, Cantley LC, Wang X, Kireev D, Baldwin AS, Janzen WP.

PLoS One. 2012;7(7):e41494. doi: 10.1371/journal.pone.0041494. Epub 2012 Jul 30.

PMID:
22859992
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis.

Fu J, Qu Z, Yan P, Ishikawa C, Aqeilan RI, Rabson AB, Xiao G.

Blood. 2011 Feb 3;117(5):1652-61. doi: 10.1182/blood-2010-08-303073. Epub 2010 Nov 29.

PMID:
21115974
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Novel splice variants of human IKKε negatively regulate IKKε-induced IRF3 and NF-kB activation.

Koop A, Lepenies I, Braum O, Davarnia P, Scherer G, Fickenscher H, Kabelitz D, Adam-Klages S.

Eur J Immunol. 2011 Jan;41(1):224-34. doi: 10.1002/eji.201040814. Epub 2010 Dec 3.

PMID:
21182093
[PubMed - indexed for MEDLINE]
17.

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.

Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW.

Mol Cell Biol. 2007 Nov;27(21):7451-61. Epub 2007 Aug 20.

PMID:
17709380
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Regulation of anoikis by deleted in breast cancer-1 (DBC1) through NF-κB.

Park SH, Riley P 4th, Frisch SM.

Apoptosis. 2013 Aug;18(8):949-62. doi: 10.1007/s10495-013-0847-1.

PMID:
23588592
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation.

Adli M, Baldwin AS.

J Biol Chem. 2006 Sep 15;281(37):26976-84. Epub 2006 Jul 13.

PMID:
16840782
[PubMed - indexed for MEDLINE]
Free Article

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