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Items: 1 to 20 of 160

1.

Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP.

J Biol Chem. 2009 Jul 17;284(29):19402-11. doi: 10.1074/jbc.M109.024711. Epub 2009 May 28.

2.

G protein selectivity is a determinant of RGS2 function.

Heximer SP, Srinivasa SP, Bernstein LS, Bernard JL, Linder ME, Hepler JR, Blumer KJ.

J Biol Chem. 1999 Nov 26;274(48):34253-9.

3.

RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.

Bernstein LS, Ramineni S, Hague C, Cladman W, Chidiac P, Levey AI, Hepler JR.

J Biol Chem. 2004 May 14;279(20):21248-56. Epub 2004 Feb 19.

4.

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457-62. doi: 10.1073/pnas.0801508105. Epub 2008 Apr 23.

5.

Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity.

Zielinski T, Kimple AJ, Hutsell SQ, Koeff MD, Siderovski DP, Lowery RG.

J Biomol Screen. 2009 Dec;14(10):1195-206. doi: 10.1177/1087057109347473. Epub .

6.

Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor.

Tang W, Tu Y, Nayak SK, Woodson J, Jehl M, Ross EM.

J Biol Chem. 2006 Feb 24;281(8):4746-53. Epub 2005 Dec 29.

7.

Characterization of the GRK2 binding site of Galphaq.

Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB.

J Biol Chem. 2004 Dec 17;279(51):53643-52. Epub 2004 Oct 7.

8.

Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.

Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T.

J Biol Chem. 1999 Nov 26;274(48):34483-92.

9.

Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members.

Gu S, He J, Ho WT, Ramineni S, Thal DM, Natesh R, Tesmer JJ, Hepler JR, Heximer SP.

J Biol Chem. 2007 Nov 9;282(45):33064-75. Epub 2007 Sep 11.

10.

Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.

Kimple AJ, Bosch DE, Giguère PM, Siderovski DP.

Pharmacol Rev. 2011 Sep;63(3):728-49. doi: 10.1124/pr.110.003038. Epub 2011 Jul 7. Review.

11.

Fusion proteins as model systems for the analysis of constitutive GPCR activity.

Schneider EH, Seifert R.

Methods Enzymol. 2010;485:459-80. doi: 10.1016/B978-0-12-381296-4.00025-7.

PMID:
21050932
12.

Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.

Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK.

J Biol Chem. 2001 Feb 23;276(8):5438-44. Epub 2000 Nov 3.

13.

G protein activation without a GEF in the plant kingdom.

Urano D, Jones JC, Wang H, Matthews M, Bradford W, Bennetzen JL, Jones AM.

PLoS Genet. 2012 Jun;8(6):e1002756. doi: 10.1371/journal.pgen.1002756. Epub 2012 Jun 28.

14.

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.

Siderovski DP, Willard FS.

Int J Biol Sci. 2005;1(2):51-66. Epub 2005 Apr 1. Review.

15.

The RGS proteins add to the diversity of soybean heterotrimeric G-protein signaling.

Choudhury SR, Westfall CS, Pandey S.

Plant Signal Behav. 2012 Sep 1;7(9):1114-7. doi: 10.4161/psb.21298. Epub 2012 Aug 17.

16.

Fluorescence-based assays for RGS box function.

Willard FS, Kimple RJ, Kimple AJ, Johnston CA, Siderovski DP.

Methods Enzymol. 2004;389:56-71. Review.

PMID:
15313559
17.
18.

A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.

Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP.

PLoS Pathog. 2012 Feb;8(2):e1002553. doi: 10.1371/journal.ppat.1002553. Epub 2012 Feb 23.

19.
20.

Differential interaction of GRK2 with members of the G alpha q family.

Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB.

Biochemistry. 2003 Aug 5;42(30):9176-84.

PMID:
12885252
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