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Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters.

Zhang T, Berrocal JG, Frizzell KM, Gamble MJ, DuMond ME, Krishnakumar R, Yang T, Sauve AA, Kraus WL.

J Biol Chem. 2009 Jul 24;284(30):20408-17. doi: 10.1074/jbc.M109.016469. Epub 2009 May 28.


SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions.

Zhang T, Kraus WL.

Biochim Biophys Acta. 2010 Aug;1804(8):1666-75. doi: 10.1016/j.bbapap.2009.10.022. Epub 2009 Oct 30. Review.


The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells.

Revollo JR, Grimm AA, Imai S.

J Biol Chem. 2004 Dec 3;279(49):50754-63. Epub 2004 Sep 20.


Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.

Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P.

Science. 2009 May 1;324(5927):654-7. doi: 10.1126/science.1170803. Epub 2009 Mar 12.


Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT.

Choi SE, Fu T, Seok S, Kim DH, Yu E, Lee KW, Kang Y, Li X, Kemper B, Kemper JK.

Aging Cell. 2013 Dec;12(6):1062-72. doi: 10.1111/acel.12135. Epub 2013 Aug 11.


Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase.

Zhang T, Berrocal JG, Yao J, DuMond ME, Krishnakumar R, Ruhl DD, Ryu KW, Gamble MJ, Kraus WL.

J Biol Chem. 2012 Apr 6;287(15):12405-16. doi: 10.1074/jbc.M111.304469. Epub 2012 Feb 13.


Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.

Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai S, Bass J.

Science. 2009 May 1;324(5927):651-4. doi: 10.1126/science.1171641. Epub 2009 Mar 19.


Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.

Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V.

Dev Cell. 2008 May;14(5):661-73. doi: 10.1016/j.devcel.2008.02.004.


Tanshinone II A inhibits tat-induced HIV-1 transactivation through redox-regulated AMPK/Nampt pathway.

Zhang HS, Chen XY, Wu TC, Zhang FJ.

J Cell Physiol. 2014 Sep;229(9):1193-201. doi: 10.1002/jcp.24552.


The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.

Menssen A, Hydbring P, Kapelle K, Vervoorts J, Diebold J, L├╝scher B, Larsson LG, Hermeking H.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):E187-96. doi: 10.1073/pnas.1105304109. Epub 2011 Dec 21.


The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target.

Pan LZ, Ahn DG, Sharif T, Clements D, Gujar SA, Lee PW.

Cell Cycle. 2014;13(6):1041-8. doi: 10.4161/cc.28128. Epub 2014 Feb 7.


Nicotinamide phosphoribosyltransferase/sirtuin 1 pathway is involved in human immunodeficiency virus type 1 Tat-mediated long terminal repeat transactivation.

Zhang HS, Sang WW, Wang YO, Liu W.

J Cell Biochem. 2010 Aug 15;110(6):1464-70. doi: 10.1002/jcb.22704.


Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase.

Dvir-Ginzberg M, Gagarina V, Lee EJ, Hall DJ.

J Biol Chem. 2008 Dec 26;283(52):36300-10. doi: 10.1074/jbc.M803196200. Epub 2008 Oct 28.


Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice.

Hayashida S, Arimoto A, Kuramoto Y, Kozako T, Honda S, Shimeno H, Soeda S.

Mol Cell Biochem. 2010 Jun;339(1-2):285-92. doi: 10.1007/s11010-010-0391-z. Epub 2010 Feb 11.


NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.

Thakur BK, Lippka Y, Dittrich T, Chandra P, Skokowa J, Welte K.

Biochem Biophys Res Commun. 2012 Apr 20;420(4):714-20. doi: 10.1016/j.bbrc.2012.03.017. Epub 2012 Mar 10.


Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.

Hsu CP, Oka S, Shao D, Hariharan N, Sadoshima J.

Circ Res. 2009 Aug 28;105(5):481-91. doi: 10.1161/CIRCRESAHA.109.203703. Epub 2009 Aug 6.


SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced.

Ho C, van der Veer E, Akawi O, Pickering JG.

FEBS Lett. 2009 Sep 17;583(18):3081-5. doi: 10.1016/j.febslet.2009.08.031. Epub 2009 Aug 29.


Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion.

Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J.

PLoS One. 2014 Jun 6;9(6):e98972. doi: 10.1371/journal.pone.0098972. eCollection 2014.

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