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Results: 1 to 20 of 99

1.

Identification of an endogenous ligand bound to a native orphan nuclear receptor.

Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM, Sladek FM.

PLoS One. 2009;4(5):e5609. doi: 10.1371/journal.pone.0005609. Epub 2009 May 19.

PMID:
19440305
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Hepatocyte nuclear factor 4α regulates the expression of the murine pyruvate carboxylase gene through the HNF4-specific binding motif in its proximal promoter.

Chavalit T, Rojvirat P, Muangsawat S, Jitrapakdee S.

Biochim Biophys Acta. 2013 Oct;1829(10):987-99. doi: 10.1016/j.bbagrm.2013.05.001. Epub 2013 May 9.

PMID:
23665043
[PubMed - indexed for MEDLINE]
3.

The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells.

Perilhou A, Tourrel-Cuzin C, Zhang P, Kharroubi I, Wang H, Fauveau V, Scott DK, Wollheim CB, Vasseur-Cognet M.

Mol Cell Biol. 2008 Jul;28(14):4588-97. doi: 10.1128/MCB.01191-07. Epub 2008 May 12.

PMID:
18474611
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.

Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB.

Nat Med. 2003 Feb;9(2):220-4. Epub 2003 Jan 6.

PMID:
12514743
[PubMed - indexed for MEDLINE]
5.

Characterization of glucocorticoid receptor and hepatocyte nuclear factor 4alpha (HNF4alpha) binding to the hnf4alpha gene in the liver.

Bailly A, Briançon N, Weiss MC.

Biochimie. 2009 Sep;91(9):1095-103. doi: 10.1016/j.biochi.2009.06.009. Epub 2009 Jun 21.

PMID:
19540905
[PubMed - indexed for MEDLINE]
6.

Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha.

Bogan AA, Dallas-Yang Q, Ruse MD Jr, Maeda Y, Jiang G, Nepomuceno L, Scanlan TS, Cohen FE, Sladek FM.

J Mol Biol. 2000 Sep 29;302(4):831-51.

PMID:
10993727
[PubMed - indexed for MEDLINE]
7.

Hepatocyte nuclear factor 4 alpha and farnesoid X receptor co-regulates gene transcription in mouse livers on a genome-wide scale.

Thomas AM, Hart SN, Li G, Lu H, Fang Y, Fang J, Zhong XB, Guo GL.

Pharm Res. 2013 Sep;30(9):2188-98. doi: 10.1007/s11095-013-1006-7. Epub 2013 Mar 6.

PMID:
23462932
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism.

Chen Z, Gropler MC, Mitra MS, Finck BN.

PLoS One. 2012;7(12):e51320. doi: 10.1371/journal.pone.0051320. Epub 2012 Dec 7.

PMID:
23236470
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression.

Nedumaran B, Hong S, Xie YB, Kim YH, Seo WY, Lee MW, Lee CH, Koo SH, Choi HS.

J Biol Chem. 2009 Oct 2;284(40):27511-23. doi: 10.1074/jbc.M109.034660. Epub 2009 Aug 3.

PMID:
19651776
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.

Surapureddi S, Rana R, Reddy JK, Goldstein JA.

Mol Pharmacol. 2008 Sep;74(3):913-23. doi: 10.1124/mol.108.048983. Epub 2008 Jun 13.

PMID:
18552123
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

MED25 is a mediator component of HNF4α-driven transcription leading to insulin secretion in pancreatic beta-cells.

Han EH, Rha GB, Chi YI.

PLoS One. 2012;7(8):e44007. doi: 10.1371/journal.pone.0044007. Epub 2012 Aug 30.

PMID:
22952853
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

HNF4α--role in drug metabolism and potential drug target?

Hwang-Verslues WW, Sladek FM.

Curr Opin Pharmacol. 2010 Dec;10(6):698-705. doi: 10.1016/j.coph.2010.08.010. Review.

PMID:
20833107
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.

Niehof M, Borlak J.

Gastroenterology. 2008 Apr;134(4):1191-202. doi: 10.1053/j.gastro.2008.01.027. Epub 2008 Jan 17.

PMID:
18395097
[PubMed - indexed for MEDLINE]
14.

Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter.

Rufibach LE, Duncan SA, Battle M, Deeb SS.

J Lipid Res. 2006 Jul;47(7):1463-77. Epub 2006 Apr 7.

PMID:
16603721
[PubMed - indexed for MEDLINE]
Free Article
15.

Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds.

Le Guével R, Oger F, Lecorgne A, Dudasova Z, Chevance S, Bondon A, Barath P, Simonneaux G, Salbert G.

Bioorg Med Chem. 2009 Oct 1;17(19):7021-30. doi: 10.1016/j.bmc.2009.07.079. Epub 2009 Aug 5.

PMID:
19729315
[PubMed - indexed for MEDLINE]
16.

Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1.

Eeckhoute J, Briche I, Kurowska M, Formstecher P, Laine B.

J Mol Biol. 2006 Dec 8;364(4):567-81. Epub 2006 Sep 12.

PMID:
17022998
[PubMed - indexed for MEDLINE]
17.

A high resolution genome-wide scan of HNF4α recognition sites infers a regulatory gene network in colon cancer.

Weltmeier F, Borlak J.

PLoS One. 2011;6(7):e21667. doi: 10.1371/journal.pone.0021667. Epub 2011 Jul 28.

PMID:
21829439
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.

Sun K, Montana V, Chellappa K, Brelivet Y, Moras D, Maeda Y, Parpura V, Paschal BM, Sladek FM.

Mol Endocrinol. 2007 Jun;21(6):1297-311. Epub 2007 Mar 27.

PMID:
17389749
[PubMed - indexed for MEDLINE]
19.

Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.

Chiang JY.

Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):137-47. doi: 10.1517/17425250802707342 . Review.

PMID:
19239393
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.

Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ.

Mol Cell Biol. 2001 Feb;21(4):1393-403.

PMID:
11158324
[PubMed - indexed for MEDLINE]
Free PMC Article
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