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Items: 1 to 20 of 81

1.

Identification of an endogenous ligand bound to a native orphan nuclear receptor.

Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM, Sladek FM.

PLoS One. 2009;4(5):e5609. doi: 10.1371/journal.pone.0005609. Epub 2009 May 19.

2.

Hepatocyte nuclear factor 4α regulates the expression of the murine pyruvate carboxylase gene through the HNF4-specific binding motif in its proximal promoter.

Chavalit T, Rojvirat P, Muangsawat S, Jitrapakdee S.

Biochim Biophys Acta. 2013 Oct;1829(10):987-99. doi: 10.1016/j.bbagrm.2013.05.001. Epub 2013 May 9.

PMID:
23665043
3.

The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells.

Perilhou A, Tourrel-Cuzin C, Zhang P, Kharroubi I, Wang H, Fauveau V, Scott DK, Wollheim CB, Vasseur-Cognet M.

Mol Cell Biol. 2008 Jul;28(14):4588-97. doi: 10.1128/MCB.01191-07. Epub 2008 May 12.

4.

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.

Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB.

Nat Med. 2003 Feb;9(2):220-4. Epub 2003 Jan 6.

PMID:
12514743
5.

Characterization of glucocorticoid receptor and hepatocyte nuclear factor 4alpha (HNF4alpha) binding to the hnf4alpha gene in the liver.

Bailly A, Briançon N, Weiss MC.

Biochimie. 2009 Sep;91(9):1095-103. doi: 10.1016/j.biochi.2009.06.009. Epub 2009 Jun 21.

PMID:
19540905
6.

Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha.

Bogan AA, Dallas-Yang Q, Ruse MD Jr, Maeda Y, Jiang G, Nepomuceno L, Scanlan TS, Cohen FE, Sladek FM.

J Mol Biol. 2000 Sep 29;302(4):831-51.

PMID:
10993727
7.

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression.

Nedumaran B, Hong S, Xie YB, Kim YH, Seo WY, Lee MW, Lee CH, Koo SH, Choi HS.

J Biol Chem. 2009 Oct 2;284(40):27511-23. doi: 10.1074/jbc.M109.034660. Epub 2009 Aug 3.

8.

MED25 is a mediator component of HNF4α-driven transcription leading to insulin secretion in pancreatic beta-cells.

Han EH, Rha GB, Chi YI.

PLoS One. 2012;7(8):e44007. doi: 10.1371/journal.pone.0044007. Epub 2012 Aug 30.

9.

HNF4α--role in drug metabolism and potential drug target?

Hwang-Verslues WW, Sladek FM.

Curr Opin Pharmacol. 2010 Dec;10(6):698-705. doi: 10.1016/j.coph.2010.08.010. Review.

10.

EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.

Niehof M, Borlak J.

Gastroenterology. 2008 Apr;134(4):1191-202. doi: 10.1053/j.gastro.2008.01.027. Epub 2008 Jan 17.

PMID:
18395097
11.

Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter.

Rufibach LE, Duncan SA, Battle M, Deeb SS.

J Lipid Res. 2006 Jul;47(7):1463-77. Epub 2006 Apr 7.

12.

Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds.

Le Guével R, Oger F, Lecorgne A, Dudasova Z, Chevance S, Bondon A, Barath P, Simonneaux G, Salbert G.

Bioorg Med Chem. 2009 Oct 1;17(19):7021-30. doi: 10.1016/j.bmc.2009.07.079. Epub 2009 Aug 5.

PMID:
19729315
13.

Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1.

Eeckhoute J, Briche I, Kurowska M, Formstecher P, Laine B.

J Mol Biol. 2006 Dec 8;364(4):567-81. Epub 2006 Sep 12.

PMID:
17022998
14.

A high resolution genome-wide scan of HNF4α recognition sites infers a regulatory gene network in colon cancer.

Weltmeier F, Borlak J.

PLoS One. 2011;6(7):e21667. doi: 10.1371/journal.pone.0021667. Epub 2011 Jul 28.

15.

Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.

Chiang JY.

Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):137-47. doi: 10.1517/17425250802707342 . Review.

16.
18.

Construction of a plasmid vector for liver-specific inhibition of hepatocyte nuclear factor 4 alpha expression.

Song XQ, Chen EQ, Wang YB, Zhou TY, Liu L, Liu C, Cheng X, Tang H.

Plasmid. 2012 Jan;67(1):60-6. doi: 10.1016/j.plasmid.2011.08.001. Epub 2011 Aug 30.

PMID:
21907733
19.

Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays.

Bolotin E, Liao H, Ta TC, Yang C, Hwang-Verslues W, Evans JR, Jiang T, Sladek FM.

Hepatology. 2010 Feb;51(2):642-53. doi: 10.1002/hep.23357.

20.

Positive regulation of hepatic miR-122 expression by HNF4α.

Li ZY, Xi Y, Zhu WN, Zeng C, Zhang ZQ, Guo ZC, Hao DL, Liu G, Feng L, Chen HZ, Chen F, Lv X, Liu DP, Liang CC.

J Hepatol. 2011 Sep;55(3):602-11. doi: 10.1016/j.jhep.2010.12.023. Epub 2011 Jan 15.

PMID:
21241755
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