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Items: 1 to 20 of 196

1.

Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.

Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP.

J Immunol. 2009 May 15;182(10):6460-9. doi: 10.4049/jimmunol.0802696.

3.

Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.

Niemi K, Teirilä L, Lappalainen J, Rajamäki K, Baumann MH, Öörni K, Wolff H, Kovanen PT, Matikainen S, Eklund KK.

J Immunol. 2011 Jun 1;186(11):6119-28. doi: 10.4049/jimmunol.1002843. Epub 2011 Apr 20.

4.

Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells.

Craven RR, Gao X, Allen IC, Gris D, Bubeck Wardenburg J, McElvania-Tekippe E, Ting JP, Duncan JA.

PLoS One. 2009 Oct 14;4(10):e7446. doi: 10.1371/journal.pone.0007446.

5.

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP.

Cell Host Microbe. 2007 Sep 13;2(3):147-59.

6.

Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia.

Hanamsagar R, Torres V, Kielian T.

J Neurochem. 2011 Nov;119(4):736-48. doi: 10.1111/j.1471-4159.2011.07481.x. Epub 2011 Oct 11.

7.

Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.

Shio MT, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA, Olivier M.

PLoS Pathog. 2009 Aug;5(8):e1000559. doi: 10.1371/journal.ppat.1000559. Epub 2009 Aug 21. Erratum in: PLoS Pathog. 2009 Sep;5(9). doi: 10.1371/annotation/abca067d-b82b-4de6-93c5-0fcc38e3df05. Tiemi Shio, Marina [corrected to Shio, Marina Tiemi].

8.

Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea.

Zhou X, Gao X, Broglie PM, Kebaier C, Anderson JE, Thom N, Apicella MA, Sempowski GD, Duncan JA.

Infect Immun. 2014 Jan;82(1):184-92. doi: 10.1128/IAI.00890-13. Epub 2013 Oct 14.

9.

Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation.

Lippai D, Bala S, Petrasek J, Csak T, Levin I, Kurt-Jones EA, Szabo G.

J Leukoc Biol. 2013 Jul;94(1):171-82. doi: 10.1189/jlb.1212659. Epub 2013 Apr 26.

10.

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages.

Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S.

Mol Immunol. 2013 Dec;56(4):471-9. doi: 10.1016/j.molimm.2013.05.005. Epub 2013 Aug 1.

PMID:
23911403
11.

Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients.

Zheng Q, Ren Y, Reinach PS, Xiao B, Lu H, Zhu Y, Qu J, Chen W.

Exp Eye Res. 2015 May;134:133-40. doi: 10.1016/j.exer.2015.02.013. Epub 2015 Feb 18.

PMID:
25701684
12.

The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages.

Huang TT, Ojcius DM, Young JD, Wu YH, Ko YF, Wong TY, Wu CY, Lu CC, Lai HC.

PLoS One. 2012;7(7):e41383. doi: 10.1371/journal.pone.0041383. Epub 2012 Jul 23.

13.

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.

Rajamäki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, Kovanen PT, Eklund KK.

PLoS One. 2010 Jul 23;5(7):e11765. doi: 10.1371/journal.pone.0011765.

14.

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

Gross O, Poeck H, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J.

Nature. 2009 May 21;459(7245):433-6. doi: 10.1038/nature07965. Epub 2009 Apr 1.

PMID:
19339971
15.

Activation of the NLRP3 inflammasome by group B streptococci.

Costa A, Gupta R, Signorino G, Malara A, Cardile F, Biondo C, Midiri A, Galbo R, Trieu-Cuot P, Papasergi S, Teti G, Henneke P, Mancuso G, Golenbock DT, Beninati C.

J Immunol. 2012 Feb 15;188(4):1953-60. doi: 10.4049/jimmunol.1102543. Epub 2012 Jan 16.

16.

Helicobacter pylori induces IL-1β and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway.

Li X, Liu S, Luo J, Liu A, Tang S, Liu S, Yu M, Zhang Y.

Pathog Dis. 2015 Jun;73(4). pii: ftu024. doi: 10.1093/femspd/ftu024. Epub 2015 Jan 5.

17.

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages.

Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB.

PLoS Pathog. 2011 Apr;7(4):e1002026. doi: 10.1371/journal.ppat.1002026. Epub 2011 Apr 21.

18.

Adenovirus membrane penetration activates the NLRP3 inflammasome.

Barlan AU, Griffin TM, McGuire KA, Wiethoff CM.

J Virol. 2011 Jan;85(1):146-55. doi: 10.1128/JVI.01265-10. Epub 2010 Oct 27.

19.

Critical role of apoptotic speck protein containing a caspase recruitment domain (ASC) and NLRP3 in causing necrosis and ASC speck formation induced by Porphyromonas gingivalis in human cells.

Huang MT, Taxman DJ, Holley-Guthrie EA, Moore CB, Willingham SB, Madden V, Parsons RK, Featherstone GL, Arnold RR, O'Connor BP, Ting JP.

J Immunol. 2009 Feb 15;182(4):2395-404. doi: 10.4049/jimmunol.0800909.

20.

NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.

Willingham SB, Allen IC, Bergstralh DT, Brickey WJ, Huang MT, Taxman DJ, Duncan JA, Ting JP.

J Immunol. 2009 Aug 1;183(3):2008-15. doi: 10.4049/jimmunol.0900138. Epub 2009 Jul 8.

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