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Results: 1 to 20 of 104

1.

Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain.

Pereira E, Chen Y, Sanchez Y.

Cell Cycle. 2009 Jun 1;8(11):1788-93. Epub 2009 Jun 15.

PMID:
19411848
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

ATRMec1 phosphorylation-independent activation of Chk1 in vivo.

Chen Y, Caldwell JM, Pereira E, Baker RW, Sanchez Y.

J Biol Chem. 2009 Jan 2;284(1):182-90. doi: 10.1074/jbc.M806530200. Epub 2008 Nov 4.

PMID:
18984588
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Regulatory motifs in Chk1.

Caparelli ML, O'Connell MJ.

Cell Cycle. 2013 Mar 15;12(6):916-22. doi: 10.4161/cc.23881. Epub 2013 Feb 19.

PMID:
23422000
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

Willis J, Patel Y, Lentz BL, Yan S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10592-7. doi: 10.1073/pnas.1301445110. Epub 2013 Jun 10.

PMID:
23754435
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.

Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A.

J Biol Chem. 2009 Nov 27;284(48):33107-14. doi: 10.1074/jbc.M109.064485. Epub 2009 Oct 14.

PMID:
19828454
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Autoregulatory mechanisms of phosphorylation of checkpoint kinase 1.

Wang J, Han X, Zhang Y.

Cancer Res. 2012 Aug 1;72(15):3786-94. doi: 10.1158/0008-5472.CAN-12-0523.

PMID:
22855742
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest.

Capasso H, Palermo C, Wan S, Rao H, John UP, O'Connell MJ, Walworth NC.

J Cell Sci. 2002 Dec 1;115(Pt 23):4555-64.

PMID:
12415000
[PubMed - indexed for MEDLINE]
Free Article
8.

Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation.

Katsuragi Y, Sagata N.

Mol Biol Cell. 2004 Apr;15(4):1680-9. Epub 2004 Feb 6.

PMID:
14767054
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation.

Ball HL, Myers JS, Cortez D.

Mol Biol Cell. 2005 May;16(5):2372-81. Epub 2005 Mar 2.

PMID:
15743907
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Regulation of Chk1 by its C-terminal domain.

Kosoy A, O'Connell MJ.

Mol Biol Cell. 2008 Nov;19(11):4546-53. doi: 10.1091/mbc.E08-04-0444. Epub 2008 Aug 20.

PMID:
18716058
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.

Zhao H, Piwnica-Worms H.

Mol Cell Biol. 2001 Jul;21(13):4129-39.

PMID:
11390642
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation.

Jeong SY, Kumagai A, Lee J, Dunphy WG.

J Biol Chem. 2003 Nov 21;278(47):46782-8. Epub 2003 Sep 8.

PMID:
12963733
[PubMed - indexed for MEDLINE]
Free Article
13.

Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast.

Lopez-Girona A, Tanaka K, Chen XB, Baber BA, McGowan CH, Russell P.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11289-94. Epub 2001 Sep 11.

PMID:
11553781
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D.

Mol Cell Biol. 2008 Dec;28(24):7345-53. doi: 10.1128/MCB.01079-08. Epub 2008 Oct 20.

PMID:
18936170
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1.

Bennett LN, Larkin C, Gillespie DA, Clarke PR.

Biochem Biophys Res Commun. 2008 May 9;369(3):973-6. doi: 10.1016/j.bbrc.2008.02.154. Epub 2008 Mar 10.

PMID:
18331829
[PubMed - indexed for MEDLINE]
16.

Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.

Lupardus PJ, Cimprich KA.

Mol Biol Cell. 2006 Apr;17(4):1559-69. Epub 2006 Jan 25.

PMID:
16436514
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A domain of Rad9 specifically required for activation of Chk1 in budding yeast.

Blankley RT, Lydall D.

J Cell Sci. 2004 Feb 1;117(Pt 4):601-8. Epub 2004 Jan 6.

PMID:
14709724
[PubMed - indexed for MEDLINE]
Free Article
18.

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

Walker M, Black EJ, Oehler V, Gillespie DA, Scott MT.

Oncogene. 2009 Jun 18;28(24):2314-23. doi: 10.1038/onc.2009.102. Epub 2009 May 4.

PMID:
19421147
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.

Clarke CA, Bennett LN, Clarke PR.

J Biol Chem. 2005 Oct 21;280(42):35337-45. Epub 2005 Aug 25.

PMID:
16123041
[PubMed - indexed for MEDLINE]
Free Article
20.

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