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Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.

ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.

Dev Cell. 2009 Apr;16(4):551-62. doi: 10.1016/j.devcel.2009.01.016.


Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ, Clevers HC.

Cell. 2004 Feb 6;116(3):457-66.


Analysis of the LKB1-STRAD-MO25 complex.

Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR.

J Cell Sci. 2004 Dec 15;117(Pt 26):6365-75. Epub 2004 Nov 23.


Epithelial polarity: dual Lkb1 pathways regulate apical microvilli.

Bretscher A.

Dev Cell. 2009 Apr;16(4):491-2. doi: 10.1016/j.devcel.2009.03.012.


MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR.

EMBO J. 2003 Oct 1;22(19):5102-14.


Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25.

Ellingson WJ, Chesser DG, Winder WW.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E400-7. Epub 2006 Sep 19.


Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.

Marignani PA, Scott KD, Bagnulo R, Cannone D, Ferrari E, Stella A, Guanti G, Simone C, Resta N.

Cancer Biol Ther. 2007 Oct;6(10):1627-31. Epub 2007 Jul 24.


Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.

Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM.

Nat Struct Mol Biol. 2004 Feb;11(2):193-200. Epub 2004 Jan 18.


LKB1 tumor suppressor protein: PARtaker in cell polarity.

Baas AF, Smit L, Clevers H.

Trends Cell Biol. 2004 Jun;14(6):312-9. Review.


Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG.

J Biol. 2003;2(4):28. Epub 2003 Sep 24.


Regulation of LKB1/STRAD localization and function by E-cadherin.

Sebbagh M, Santoni MJ, Hall B, Borg JP, Schwartz MA.

Curr Biol. 2009 Jan 13;19(1):37-42. doi: 10.1016/j.cub.2008.11.033. Epub 2008 Dec 24.


ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM.

PLoS Biol. 2009 Jun 9;7(6):e1000126. doi: 10.1371/journal.pbio.1000126. Epub 2009 Jun 9.


Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM.

Science. 2009 Dec 18;326(5960):1707-11. doi: 10.1126/science.1178377. Epub 2009 Nov 5.


Structure of the MST4 in complex with MO25 provides insights into its activation mechanism.

Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L, Zhao Y, Zhou Z.

Structure. 2013 Mar 5;21(3):449-61. doi: 10.1016/j.str.2013.01.007. Epub 2013 Feb 21.


Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.

Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC.

EMBO J. 2003 Jun 16;22(12):3062-72.


Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.

Neumann D, Suter M, Tuerk R, Riek U, Wallimann T.

Mol Biotechnol. 2007 Jul;36(3):220-31.


A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity.

Martin SG, St Johnston D.

Nature. 2003 Jan 23;421(6921):379-84.


Rap2A links intestinal cell polarity to brush border formation.

Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL.

Nat Cell Biol. 2012 Aug;14(8):793-801. doi: 10.1038/ncb2537. Epub 2012 Jul 15.


STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.

Dorfman J, Macara IG.

Mol Biol Cell. 2008 Apr;19(4):1614-26. doi: 10.1091/mbc.E07-05-0454. Epub 2008 Feb 6.


MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.

Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR.

EMBO J. 2011 May 4;30(9):1730-41. doi: 10.1038/emboj.2011.78. Epub 2011 Mar 18.

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