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The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma.

Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA.

Cancer Res. 2009 Apr 1;69(7):2809-16. doi: 10.1158/0008-5472.CAN-08-4079.


RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.

Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA.

Cancer Res. 2009 May 15;69(10):4107-11. doi: 10.1158/0008-5472.CAN-09-0474. Epub 2009 May 12.


Opposing effect of EGFRWT on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch.

Puliyappadamba VT, Chakraborty S, Chauncey SS, Li L, Hatanpaa KJ, Mickey B, Noorani S, Shu HK, Burma S, Boothman DA, Habib AA.

Cell Rep. 2013 Aug 29;4(4):764-75. doi: 10.1016/j.celrep.2013.07.025. Epub 2013 Aug 22.


Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.

Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, Vucic D, Debatin KM, Fulda S.

Oncogene. 2013 Feb 21;32(8):988-97. doi: 10.1038/onc.2012.108. Epub 2012 Apr 2.


Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway.

Garner JM, Fan M, Yang CH, Du Z, Sims M, Davidoff AM, Pfeffer LM.

J Biol Chem. 2013 Sep 6;288(36):26167-76. doi: 10.1074/jbc.M113.477950. Epub 2013 Jul 31.


A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.

Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA.

Mol Cell Biol. 2011 Jul;31(14):2774-86. doi: 10.1128/MCB.01139-10. Epub 2011 May 23.


Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.

Fujioka S, Schmidt C, Sclabas GM, Li Z, Pelicano H, Peng B, Yao A, Niu J, Zhang W, Evans DB, Abbruzzese JL, Huang P, Chiao PJ.

J Biol Chem. 2004 Jun 25;279(26):27549-59. Epub 2004 Apr 21.


RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR.

Ramnarain DB, Paulmurugan R, Park S, Mickey BE, Asaithamby A, Saha D, Kelliher MA, Mukhopadhyay P, Banani F, Madden CJ, Wright PS, Chakravarty S, Habib AA.

Cell Death Differ. 2008 Feb;15(2):344-53. Epub 2007 Nov 16.


Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway.

Zhuang C, Miao Z, Wu Y, Guo Z, Li J, Yao J, Xing C, Sheng C, Zhang W.

J Med Chem. 2014 Feb 13;57(3):567-77. doi: 10.1021/jm401800k. Epub 2014 Jan 24.


Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J.

J Biol Chem. 2010 Jan 8;285(2):969-78. doi: 10.1074/jbc.M109.042689. Epub 2009 Nov 12.


Cytoplasmic TRADD confers a worse prognosis in glioblastoma.

Chakraborty S, Li L, Tang H, Xie Y, Puliyappadamba VT, Raisanen J, Burma S, Boothman DA, Cochran B, Wu J, Habib AA.

Neoplasia. 2013 Aug;15(8):888-97.


Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

Aleyasin H, Cregan SP, Iyirhiaro G, O'Hare MJ, Callaghan SM, Slack RS, Park DS.

J Neurosci. 2004 Mar 24;24(12):2963-73.


Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response.

Karl S, Pritschow Y, Volcic M, Häcker S, Baumann B, Wiesmüller L, Debatin KM, Fulda S.

J Cell Mol Med. 2009 Oct;13(10):4239-56. doi: 10.1111/j.1582-4934.2009.00888.x. Epub 2009 Sep 1.


Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells.

Jeong SJ, Pise-Masison CA, Radonovich MF, Park HU, Brady JN.

Oncogene. 2005 Oct 6;24(44):6719-28.


Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.

Bist P, Leow SC, Phua QH, Shu S, Zhuang Q, Loh WT, Nguyen TH, Zhou JB, Hooi SC, Lim LH.

Oncogene. 2011 Jul 14;30(28):3174-85. doi: 10.1038/onc.2011.28. Epub 2011 Mar 7.


5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma.

Coupienne I, Fettweis G, Rubio N, Agostinis P, Piette J.

Photochem Photobiol Sci. 2011 Dec;10(12):1868-78. doi: 10.1039/c1pp05213f. Epub 2011 Oct 28.


DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.

Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J.

EMBO Rep. 2009 Aug;10(8):916-22. doi: 10.1038/embor.2009.109. Epub 2009 Jul 10.

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