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IL-12 and IL-18 induction and subsequent NKT activation effects of the Japanese botanical medicine Juzentaihoto.

Fujiki K, Nakamura M, Matsuda T, Isogai M, Ikeda M, Yamamoto Y, Kitamura M, Sazaki N, Yakushiji F, Suzuki S, Tomiyama J, Uchida T, Taniguchi K.

Int J Mol Sci. 2008 Jun;9(7):1142-55. doi: 10.3390/ijms9071142. Epub 2008 Jul 8.


Induction of mononuclear cell infiltration into liver by Japanese herbal medicine.

Matsuda T, Uzuki M, Uchida T, Nakamura M, Tai M, Shiraishi N, Sazaki N, Yakushiji F, Tomiyama J, Suzuki S, Fujiki K, Taniguchi K.

Drugs Exp Clin Res. 2005;31(5-6):207-14.


Suppressive effect of juzen-taiho-to on lung metastasis of b16 melanoma cells in vivo.

Matsuda T, Maekawa K, Asano K, Hisamitsu T.

Evid Based Complement Alternat Med. 2011;2011:743153. doi: 10.1093/ecam/nen081. Epub 2011 Jun 5.


Anti-angiogenic and immunomodulatory effect of the herbal medicine "Juzen-taiho-to" on malignant glioma.

Kamiyama H, Takano S, Ishikawa E, Tsuboi K, Matsumura A.

Biol Pharm Bull. 2005 Nov;28(11):2111-6.


Natural killer T cells from interleukin-4-deficient mice are defective in early interferon-gamma production in response to alpha-galactosylceramide.

Togashi Y, Chamoto K, Wakita D, Tsutsumi N, Iwakura Y, Matsubara N, Kitamura H, Nishimura T.

Cancer Sci. 2007 May;98(5):721-5. Epub 2007 Mar 14.


Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice.

Chen J, Duan L, Xiong A, Zhang H, Zheng F, Tan Z, Gong F, Fang M.

J Mol Med (Berl). 2012 Dec;90(12):1505-15. doi: 10.1007/s00109-012-0938-4. Epub 2012 Sep 16.


Juzentaihoto Failed to Augment Antigen-Specific Immunity but Prevented Deterioration of Patients' Conditions in Advanced Pancreatic Cancer under Personalized Peptide Vaccine.

Yutani S, Komatsu N, Matsueda S, Yoshitomi M, Shirahama T, Yamada A, Itoh K, Sasada T.

Evid Based Complement Alternat Med. 2013;2013:981717. doi: 10.1155/2013/981717. Epub 2013 Jun 10.


IL-18 time-dependently modulates Th1/Th2 cytokine production by ligand-activated NKT cells.

Uchida T, Kinoshita M, Fukasawa M, Habu Y, Shinomiya N, Seki S.

Eur J Immunol. 2007 Apr;37(4):966-77.


Enhancement of the synthetic ligand-mediated function of liver NK1.1Ag+ T cells in mice by interleukin-12 pretreatment.

Habu Y, Uchida T, Inui T, Nakashima H, Fukasawa M, Seki S.

Immunology. 2004 Sep;113(1):35-43.


Interleukin-10 suppresses natural killer cell but not natural killer T cell activation during bacterial infection.

Scott MJ, Hoth JJ, Turina M, Woods DR, Cheadle WG.

Cytokine. 2006 Jan 21;33(2):79-86. Epub 2006 Feb 20.


Enhanced production of hematopoietic growth factors through T cell activation in Peyer's patches by oral administration of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To".

Hong T, Matsumoto T, Kiyohara H, Yamada H.

Phytomedicine. 1998 Oct;5(5):353-60. doi: 10.1016/S0944-7113(98)80017-2.


Suppressive effect of juzentaihoto on vascularization induced by b16 melanoma cells in vitro and in vivo.

Ishikawa S, Ishikawa T, Asano K, Fujiwara H, Okada M, Sunagawa M, Hisamitsu T.

Evid Based Complement Alternat Med. 2012;2012:945714. doi: 10.1155/2012/945714. Epub 2011 Oct 27.


Activating immunity in the liver. II. IFN-beta attenuates NK cell-dependent liver injury triggered by liver NKT cell activation.

Trobonjaca Z, Kröger A, Stober D, Leithäuser F, Möller P, Hauser H, Schirmbeck R, Reimann J.

J Immunol. 2002 Apr 15;168(8):3763-70.


Protective effect of the Japanese traditional medicine juzentaihoto on myelosuppression induced by the anticancer drug TS-1 and identification of a potential biomarker of this effect.

Ogawa K, Omatsu T, Matsumoto C, Tsuchiya N, Yamamoto M, Naito Y, Yoshikawa T.

BMC Complement Altern Med. 2012 Aug 9;12:118. doi: 10.1186/1472-6882-12-118.


Enhanced gamma interferon production through activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis.

Kawakami K, Kinjo Y, Yara S, Uezu K, Koguchi Y, Tohyama M, Azuma M, Takeda K, Akira S, Saito A.

Infect Immun. 2001 Nov;69(11):6643-50.

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