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Results: 1 to 20 of 164

1.

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.

Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW, Duchen MR, Abramov AY.

Mol Cell. 2009 Mar 13;33(5):627-38. doi: 10.1016/j.molcel.2009.02.013.

PMID:
19285945
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease.

Gandhi S, Vaarmann A, Yao Z, Duchen MR, Wood NW, Abramov AY.

PLoS One. 2012;7(5):e37564. doi: 10.1371/journal.pone.0037564. Epub 2012 May 25.

PMID:
22662171
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

Akundi RS, Huang Z, Eason J, Pandya JD, Zhi L, Cass WA, Sullivan PG, Büeler H.

PLoS One. 2011 Jan 13;6(1):e16038. doi: 10.1371/journal.pone.0016038.

PMID:
21249202
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The Parkinson's disease-associated gene PINK1 protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1.

Zhao Y, Chen F, Chen S, Liu X, Cui M, Dong Q.

J Neurochem. 2013 Dec;127(5):711-22. doi: 10.1111/jnc.12340. Epub 2013 Jul 1.

PMID:
23772688
[PubMed - indexed for MEDLINE]
5.

Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells.

Cui T, Fan C, Gu L, Gao H, Liu Q, Zhang T, Qi Z, Zhao C, Zhao H, Cai Q, Yang H.

Brain Res. 2011 Jun 7;1394:1-13. doi: 10.1016/j.brainres.2011.01.035. Epub 2011 Jan 21.

PMID:
21262209
[PubMed - indexed for MEDLINE]
6.

Regulation of mitochondrial permeability transition pore by PINK1.

Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J.

Mol Neurodegener. 2012 May 25;7:22. doi: 10.1186/1750-1326-7-22.

PMID:
22630785
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance.

Heeman B, Van den Haute C, Aelvoet SA, Valsecchi F, Rodenburg RJ, Reumers V, Debyser Z, Callewaert G, Koopman WJ, Willems PH, Baekelandt V.

J Cell Sci. 2011 Apr 1;124(Pt 7):1115-25. doi: 10.1242/jcs.078303. Epub 2011 Mar 8.

PMID:
21385841
[PubMed - indexed for MEDLINE]
Free Article
8.

Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease.

Yao Z, Gandhi S, Burchell VS, Plun-Favreau H, Wood NW, Abramov AY.

J Cell Sci. 2011 Dec 15;124(Pt 24):4194-202. doi: 10.1242/jcs.088260. Epub 2012 Jan 5.

PMID:
22223879
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.

Wang HL, Chou AH, Wu AS, Chen SY, Weng YH, Kao YC, Yeh TH, Chu PJ, Lu CS.

Biochim Biophys Acta. 2011 Jun;1812(6):674-84. doi: 10.1016/j.bbadis.2011.03.007. Epub 2011 Mar 21.

PMID:
21421046
[PubMed - indexed for MEDLINE]
Free Article
10.

Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.

Siddall HK, Yellon DM, Ong SB, Mukherjee UA, Burke N, Hall AR, Angelova PR, Ludtmann MH, Deas E, Davidson SM, Mocanu MM, Hausenloy DJ.

PLoS One. 2013 Apr 29;8(4):e62400. doi: 10.1371/journal.pone.0062400. Print 2013. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/94fd6502-4b2d-409c-8836-66fe6ebc03ab.

PMID:
23638067
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.

Wang HL, Chou AH, Yeh TH, Li AH, Chen YL, Kuo YL, Tsai SR, Yu ST.

Neurobiol Dis. 2007 Nov;28(2):216-26. Epub 2007 Jul 17.

PMID:
17707122
[PubMed - indexed for MEDLINE]
12.

The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells.

Shim JH, Yoon SH, Kim KH, Han JY, Ha JY, Hyun DH, Paek SH, Kang UJ, Zhuang X, Son JH.

Mitochondrion. 2011 Sep;11(5):707-15. doi: 10.1016/j.mito.2011.05.013. Epub 2011 Jun 2.

PMID:
21664494
[PubMed - indexed for MEDLINE]
13.

PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice.

Deas E, Piipari K, Machhada A, Li A, Gutierrez-del-Arroyo A, Withers DJ, Wood NW, Abramov AY.

Open Biol. 2014 May 7;4:140051. doi: 10.1098/rsob.140051.

PMID:
24806840
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects.

Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N.

Neurobiol Dis. 2011 Jan;41(1):111-8. doi: 10.1016/j.nbd.2010.08.027. Epub 2010 Sep 15.

PMID:
20817094
[PubMed - indexed for MEDLINE]
15.

Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening.

Giaime E, Yamaguchi H, Gautier CA, Kitada T, Shen J.

PLoS One. 2012;7(7):e40501. doi: 10.1371/journal.pone.0040501. Epub 2012 Jul 9.

PMID:
22792356
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression.

Gómez-Sánchez R, Gegg ME, Bravo-San Pedro JM, Niso-Santano M, Alvarez-Erviti L, Pizarro-Estrella E, Gutiérrez-Martín Y, Alvarez-Barrientos A, Fuentes JM, González-Polo RA, Schapira AH.

Neurobiol Dis. 2014 Feb;62:426-40. doi: 10.1016/j.nbd.2013.10.021. Epub 2013 Oct 29.

PMID:
24184327
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function.

Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9572-7. doi: 10.1073/pnas.1106291108. Epub 2011 May 23.

PMID:
21606348
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function.

Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, Haddad D, Frezza C, Mandemakers W, Vogt-Weisenhorn D, Van Coster R, Wurst W, Scorrano L, De Strooper B.

EMBO Mol Med. 2009 May;1(2):99-111. doi: 10.1002/emmm.200900006.

PMID:
20049710
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.

Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C.

J Neurosci. 2007 Nov 7;27(45):12413-8.

PMID:
17989306
[PubMed - indexed for MEDLINE]
Free Article
20.

Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.

Liu D, Chan SL, de Souza-Pinto NC, Slevin JR, Wersto RP, Zhan M, Mustafa K, de Cabo R, Mattson MP.

Neuromolecular Med. 2006;8(3):389-414.

PMID:
16775390
[PubMed - indexed for MEDLINE]
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