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Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.

Shiotani B, Zou L.

Mol Cell. 2009 Mar 13;33(5):547-58. doi: 10.1016/j.molcel.2009.01.024.


Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks.

Tomimatsu N, Tahimic CG, Otsuki A, Burma S, Fukuhara A, Sato K, Shiota G, Oshimura M, Chen DJ, Kurimasa A.

J Biol Chem. 2007 Apr 6;282(14):10138-45. Epub 2007 Feb 1.


Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.

Shiotani B, Nguyen HD, Håkansson P, Maréchal A, Tse A, Tahara H, Zou L.

Cell Rep. 2013 May 30;3(5):1651-62. doi: 10.1016/j.celrep.2013.04.018. Epub 2013 May 16.


Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.

Tomimatsu N, Mukherjee B, Burma S.

EMBO Rep. 2009 Jun;10(6):629-35. doi: 10.1038/embor.2009.60. Epub 2009 May 15.


A human cell extract-based assay for the activation of ATM and ATR checkpoint kinases.

Shiotani B, Zou L.

Methods Mol Biol. 2011;782:181-91. doi: 10.1007/978-1-61779-273-1_13.


Function of the ATR N-terminal domain revealed by an ATM/ATR chimera.

Chen X, Zhao R, Glick GG, Cortez D.

Exp Cell Res. 2007 May 1;313(8):1667-74. Epub 2007 Feb 27.


The impact of heterochromatin on DSB repair.

Goodarzi AA, Noon AT, Jeggo PA.

Biochem Soc Trans. 2009 Jun;37(Pt 3):569-76. doi: 10.1042/BST0370569.


ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability.

Shin MH, Yuan M, Zhang H, Margolick JB, Kai M.

Cell Cycle. 2012 May 1;11(9):1796-803. doi: 10.4161/cc.20161. Epub 2012 May 1.


ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.

Ammazzalorso F, Pirzio LM, Bignami M, Franchitto A, Pichierri P.

EMBO J. 2010 Sep 15;29(18):3156-69. doi: 10.1038/emboj.2010.205. Epub 2010 Aug 27.


A positive role for c-Abl in Atm and Atr activation in DNA damage response.

Wang X, Zeng L, Wang J, Chau JF, Lai KP, Jia D, Poonepalli A, Hande MP, Liu H, He G, He L, Li B.

Cell Death Differ. 2011 Jan;18(1):5-15. doi: 10.1038/cdd.2010.106. Epub 2010 Aug 27.


Activation of DSB processing requires phosphorylation of CtIP by ATR.

Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J.

Mol Cell. 2013 Feb 21;49(4):657-67. doi: 10.1016/j.molcel.2012.11.020. Epub 2012 Dec 27.


Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair.

Joyce EF, Pedersen M, Tiong S, White-Brown SK, Paul A, Campbell SD, McKim KS.

J Cell Biol. 2011 Oct 31;195(3):359-67. doi: 10.1083/jcb.201104121. Epub 2011 Oct 24.


Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

J Biol Chem. 2007 Jun 15;282(24):17501-6. Epub 2007 Apr 19.


ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

Lee JH, Paull TT.

Science. 2005 Apr 22;308(5721):551-4. Epub 2005 Mar 24. Erratum in: Science. 2005 Jun 24;308(5730):1870.


Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.

Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J.

J Cell Biol. 2011 Sep 5;194(5):705-20. doi: 10.1083/jcb.201103103.


Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase.

McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, Schwartz G, Tse A.

Cell Cycle. 2010 Mar 1;9(5):995-1004. Epub 2010 Mar 14.


ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.

Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP.

Nat Cell Biol. 2006 Jan;8(1):37-45. Epub 2005 Dec 4.


Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation.

Veuger SJ, Durkacz BW.

DNA Repair (Amst). 2011 Feb 7;10(2):235-44. doi: 10.1016/j.dnarep.2010.11.005. Epub 2010 Dec 8.


Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.

Chen Y, Chen CF, Riley DJ, Chen PL.

Cell Cycle. 2011 Feb 15;10(4):655-63. Epub 2011 Feb 15.


Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

Lee JH, Paull TT.

Oncogene. 2007 Dec 10;26(56):7741-8. Review.

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