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Results: 1 to 20 of 108

1.

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors.

Akgün E, Körner M, Gao F, Harikumar KG, Waser B, Reubi JC, Portoghese PS, Miller LJ.

J Med Chem. 2009 Apr 9;52(7):2138-47. doi: 10.1021/jm801439x.

PMID:
19271701
[PubMed - indexed for MEDLINE]
Free PMC Article
2.
3.

Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor.

Hadac EM, Dawson ES, Darrow JW, Sugg EE, Lybrand TP, Miller LJ.

J Med Chem. 2006 Feb 9;49(3):850-63.

PMID:
16451051
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.

Semple G, Ryder H, Rooker DP, Batt AR, Kendrick DA, Szelke M, Ohta M, Satoh M, Nishida A, Akuzawa S, Miyata K.

J Med Chem. 1997 Jan 31;40(3):331-41.

PMID:
9022799
[PubMed - indexed for MEDLINE]
5.

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor.

Harikumar KG, Cawston EE, Lam PC, Patil A, Orry A, Henke BR, Abagyan R, Christopoulos A, Sexton PM, Miller LJ.

J Biol Chem. 2013 Jul 19;288(29):21082-95. doi: 10.1074/jbc.M113.480715. Epub 2013 Jun 10.

PMID:
23754289
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Novel, achiral 1,3,4-benzotriazepine analogues of 1,4-benzodiazepine-based CCK(2) antagonists that display high selectivity over CCK(1) receptors.

McDonald IM, Austin C, Buck IM, Dunstone DJ, Griffin E, Harper EA, Hull RA, Kalindjian SB, Linney ID, Low CM, Pether MJ, Spencer J, Wright PT, Adatia T, Bashall A.

J Med Chem. 2006 Apr 6;49(7):2253-61.

PMID:
16570921
[PubMed - indexed for MEDLINE]
7.

Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.

Nishida A, Miyata K, Tsutsumi R, Yuki H, Akuzawa S, Kobayashi A, Kamato T, Ito H, Yamano M, Katuyama Y, et al.

J Pharmacol Exp Ther. 1994 May;269(2):725-31.

PMID:
7910212
[PubMed - indexed for MEDLINE]
8.

Selective non-peptide ligands for an accommodating peptide receptor. Imidazobenzodiazepines as potent cholecystokinin type B receptor antagonists.

Bock MG, DiPardo RM, Newton RC, Bergman JM, Veber DF, Freedman SB, Smith AJ, Chapman KL, Patel S, Kemp JA, et al.

Bioorg Med Chem. 1994 Sep;2(9):987-98.

PMID:
7712133
[PubMed - indexed for MEDLINE]
9.

CCK receptor antagonists.

Dunlop J.

Gen Pharmacol. 1998 Oct;31(4):519-24. Review.

PMID:
9792209
[PubMed - indexed for MEDLINE]
10.
11.

Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors.

Behr TM, Jenner N, Béhé M, Angerstein C, Gratz S, Raue F, Becker W.

J Nucl Med. 1999 Jun;40(6):1029-44.

PMID:
10452322
[PubMed - indexed for MEDLINE]
Free Article
12.

Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist.

Chang RS, Lotti VJ.

Proc Natl Acad Sci U S A. 1986 Jul;83(13):4923-6.

PMID:
3014520
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.

Patel S, Smith AJ, Chapman KL, Fletcher AE, Kemp JA, Marshall GR, Hargreaves RJ, Ryecroft W, Iversen LL, Iversen SD, et al.

Mol Pharmacol. 1994 Nov;46(5):943-8.

PMID:
7969084
[PubMed - indexed for MEDLINE]
14.
15.

Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.

Hirst GC, Aquino C, Birkemo L, Croom DK, Dezube M, Dougherty RW Jr, Ervin GN, Grizzle MK, Henke B, James MK, Johnson MF, Momtahen T, Queen KL, Sherrill RG, Szewczyk J, Willson TM, Sugg EE.

J Med Chem. 1996 Dec 20;39(26):5236-45.

PMID:
8978852
[PubMed - indexed for MEDLINE]
16.

Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists.

Ursini A, Capelli AM, Carr RA, Cassarà P, Corsi M, Curcuruto O, Curotto G, Dal Cin M, Davalli S, Donati D, Feriani A, Finch H, Finizia G, Gaviraghi G, Marien M, Pentassuglia G, Polinelli S, Ratti E, Reggiani AM, Tarzia G, Tedesco G, Tranquillini ME, Trist DG, Van Amsterdam FT.

J Med Chem. 2000 Oct 5;43(20):3596-613. Erratum in: J Med Chem 2000 Dec 28;43(26):5057. Reggiani A [corrected to Reggiani AM].

PMID:
11020274
[PubMed - indexed for MEDLINE]
17.

5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.

Castro JL, Broughton HB, Russell MG, Rathbone D, Watt AP, Ball RG, Chapman KL, Patel S, Smith AJ, Marshall GR, Matassa VG.

J Med Chem. 1997 Aug 1;40(16):2491-501.

PMID:
9258356
[PubMed - indexed for MEDLINE]
18.

Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419.

Tabuchi S, Ito H, Sogabe H, Kuno M, Kinoshita T, Katumi I, Yamamoto N, Mitsui H, Satoh Y.

Chem Pharm Bull (Tokyo). 2000 Jan;48(1):1-15.

PMID:
10705468
[PubMed - indexed for MEDLINE]
19.
20.

Mutations within the cholecystokinin-B/gastrin receptor ligand 'pocket' interconvert the functions of nonpeptide agonists and antagonists.

Bläker M, Ren Y, Gordon MC, Hsu JE, Beinborn M, Kopin AS.

Mol Pharmacol. 1998 Nov;54(5):857-63.

PMID:
9804620
[PubMed - indexed for MEDLINE]
Free Article

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