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Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.

Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP.

Nat Cell Biol. 2009 Apr;11(4):420-32. doi: 10.1038/ncb1849. Epub 2009 Mar 8.


Skp2: caught in the Akt.

Ecker K, Hengst L.

Nat Cell Biol. 2009 Apr;11(4):377-9. doi: 10.1038/ncb0409-377.


Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.

Bashir T, Pagan JK, Busino L, Pagano M.

Cell Cycle. 2010 Mar 1;9(5):971-4. Epub 2010 Mar 9.


Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.

Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W.

Nat Cell Biol. 2009 Apr;11(4):397-408. doi: 10.1038/ncb1847. Epub 2009 Mar 8.


Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2).

Song GJ, Leslie KL, Barrick S, Mamonova T, Fitzpatrick JM, Drombosky KW, Peyser N, Wang B, Pellegrini M, Bauer PM, Friedman PA, Mierke DF, Bisello A.

J Biol Chem. 2015 Jan 30;290(5):2879-87. doi: 10.1074/jbc.M114.609768. Epub 2014 Dec 9.


Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.

Bornstein G, Ganoth D, Hershko A.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20. Epub 2006 Jul 21.


Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP.

Nature. 2010 Mar 18;464(7287):374-9. doi: 10.1038/nature08815. Erratum in: Nature. 2010 Jul 15;466(7304):398. Chan, Chan-Hsin [corrected to Chan, Chia-Hsin].


Regulation of Skp2 expression and activity and its role in cancer progression.

Chan CH, Lee SW, Wang J, Lin HK.

ScientificWorldJournal. 2010 Jun 1;10:1001-15. doi: 10.1100/tsw.2010.89. Review.


von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage.

Roe JS, Kim HR, Hwang IY, Cho EJ, Youn HD.

Oncogene. 2011 Jul 14;30(28):3127-38. doi: 10.1038/onc.2011.40. Epub 2011 Feb 28.


SCF(╬▓-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.

Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W.

Oncotarget. 2014 Feb 28;5(4):1026-37.


Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.

Yao ZP, Zhou M, Kelly SE, Seeliger MA, Robinson CV, Itzhaki LS.

J Mol Biol. 2006 Oct 27;363(3):673-86. Epub 2006 Aug 16.


PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2).

Mamillapalli R, Gavrilova N, Mihaylova VT, Tsvetkov LM, Wu H, Zhang H, Sun H.

Curr Biol. 2001 Feb 20;11(4):263-7.


Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.

Nature. 2004 Mar 11;428(6979):190-3.


Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.

Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, Kitagawa M, Nakayama K, Hatakeyama S.

EMBO J. 2000 May 2;19(9):2069-81.


Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.

Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr.

Nature. 2004 Mar 11;428(6979):194-8.


Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.

Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S.

Cell Cycle. 2010 Mar 1;9(5):975-9. Epub 2010 Mar 9.


Prodigiosin down-regulates SKP2 to induce p27(KIP1) stabilization and antiproliferation in human lung adenocarcinoma cells.

Hsieh HY, Shieh JJ, Chen CJ, Pan MY, Yang SY, Lin SC, Chang JS, Lee AY, Chang CC.

Br J Pharmacol. 2012 Aug;166(7):2095-108. doi: 10.1111/j.1476-5381.2012.01921.x.

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