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Items: 1 to 20 of 93

1.

Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor.

Anand R, Maksimoska J, Pagano N, Wong EY, Gimotty PA, Diamond SL, Meggers E, Marmorstein R.

J Med Chem. 2009 Mar 26;52(6):1602-11. doi: 10.1021/jm8005806.

2.

Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.

Collak FK, Yagiz K, Luthringer DJ, Erkaya B, Cinar B.

J Biol Chem. 2012 Jul 6;287(28):23698-709. doi: 10.1074/jbc.M112.358713. Epub 2012 May 22.

3.

Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes.

Maksimoska J, Feng L, Harms K, Yi C, Kissil J, Marmorstein R, Meggers E.

J Am Chem Soc. 2008 Nov 26;130(47):15764-5. doi: 10.1021/ja805555a.

4.

Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation.

Glantschnig H, Rodan GA, Reszka AA.

J Biol Chem. 2002 Nov 8;277(45):42987-96. Epub 2002 Sep 9.

5.

Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.

Yuan Z, Kim D, Shu S, Wu J, Guo J, Xiao L, Kaneko S, Coppola D, Cheng JQ.

J Biol Chem. 2010 Feb 5;285(6):3815-24. doi: 10.1074/jbc.M109.059675. Epub 2009 Nov 24.

7.

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

Bullock AN, Russo S, Amos A, Pagano N, Bregman H, Debreczeni JE, Lee WH, von Delft F, Meggers E, Knapp S.

PLoS One. 2009 Oct 20;4(10):e7112. doi: 10.1371/journal.pone.0007112.

8.

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD.

Structure. 2001 Dec;9(12):1143-52.

9.

ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival.

Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD, Nicosia SV, Testa JR, Cheng JQ.

J Biol Chem. 2005 Jun 3;280(22):21483-90. Epub 2005 Mar 22.

10.

MST1 promotes apoptosis through phosphorylation of histone H2AX.

Wen W, Zhu F, Zhang J, Keum YS, Zykova T, Yao K, Peng C, Zheng D, Cho YY, Ma WY, Bode AM, Dong Z.

J Biol Chem. 2010 Dec 10;285(50):39108-16. doi: 10.1074/jbc.M110.151753. Epub 2010 Oct 4.

11.

Organometallic compounds with biological activity: a very selective and highly potent cellular inhibitor for glycogen synthase kinase 3.

Atilla-Gokcumen GE, Williams DS, Bregman H, Pagano N, Meggers E.

Chembiochem. 2006 Sep;7(9):1443-50.

PMID:
16858717
12.

MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment.

Oh HJ, Kim MJ, Song SJ, Kim T, Lee D, Kwon SH, Choi EJ, Lim DS.

Curr Biol. 2010 Mar 9;20(5):416-22. doi: 10.1016/j.cub.2009.12.054. Epub 2010 Feb 18.

13.

Serine-threonine kinase 38 is regulated by glycogen synthase kinase-3 and modulates oxidative stress-induced cell death.

Enomoto A, Kido N, Ito M, Takamatsu N, Miyagawa K.

Free Radic Biol Med. 2012 Jan 15;52(2):507-15. doi: 10.1016/j.freeradbiomed.2011.11.006. Epub 2011 Nov 13.

PMID:
22142472
14.

Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases.

Cozza G, Sarno S, Ruzzene M, Girardi C, Orzeszko A, Kazimierczuk Z, Zagotto G, Bonaiuto E, Di Paolo ML, Pinna LA.

Biochim Biophys Acta. 2013 Jul;1834(7):1402-9. doi: 10.1016/j.bbapap.2013.01.018. Epub 2013 Jan 27.

PMID:
23360763
15.

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.

Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ.

Structure. 2004 Oct;12(10):1891-900.

16.

The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.

Xie P, Streu C, Qin J, Bregman H, Pagano N, Meggers E, Marmorstein R.

Biochemistry. 2009 Jun 16;48(23):5187-98. doi: 10.1021/bi802067u.

17.

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.

Tong Y, Stewart KD, Thomas S, Przytulinska M, Johnson EF, Klinghofer V, Leverson J, McCall O, Soni NB, Luo Y, Lin NH, Sowin TJ, Giranda VL, Penning TD.

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5206-8. doi: 10.1016/j.bmcl.2008.08.079. Epub 2008 Aug 28.

PMID:
18790640
18.

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, Allis CD.

Cell. 2003 May 16;113(4):507-17.

19.

Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei.

Salas TR, Reddy SA, Clifford JL, Davis RJ, Kikuchi A, Lippman SM, Menter DG.

J Biol Chem. 2003 Oct 17;278(42):41338-46. Epub 2003 Aug 4.

20.

Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation.

Rössig L, Badorff C, Holzmann Y, Zeiher AM, Dimmeler S.

J Biol Chem. 2002 Mar 22;277(12):9684-9. Epub 2002 Jan 4.

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