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Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.

Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM.

Biochemistry. 2009 Mar 31;48(12):2630-42. doi: 10.1021/bi801853a. Erratum in: Biochemistry. 2010 Nov 23;49(46):10037.


Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation.

Medkova M, Preininger AM, Yu NJ, Hubbell WL, Hamm HE.

Biochemistry. 2002 Aug 6;41(31):9962-72.


Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins.

Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP.

J Mol Biol. 2009 Nov 6;393(4):882-97. doi: 10.1016/j.jmb.2009.08.043. Epub 2009 Aug 22.


Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins.

Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7927-32. Epub 2007 Apr 26.


A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit.

Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE.

J Biol Chem. 2014 Aug 29;289(35):24475-87. doi: 10.1074/jbc.M114.572875. Epub 2014 Jul 18.


Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.

Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR.

Structure. 1996 Nov 15;4(11):1277-90.


Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.

Thomas CJ, Tall GG, Adhikari A, Sprang SR.

J Biol Chem. 2008 Aug 22;283(34):23150-60. doi: 10.1074/jbc.M802422200. Epub 2008 Jun 9.


A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.

Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM.

J Biol Chem. 2014 Apr 18;289(16):11331-41. doi: 10.1074/jbc.M113.539064. Epub 2014 Mar 4.


Evidence for a second, high affinity Gbetagamma binding site on Galphai1(GDP) subunits.

Wang J, Sengupta P, Guo Y, Golebiewska U, Scarlata S.

J Biol Chem. 2009 Jun 19;284(25):16906-13. doi: 10.1074/jbc.M109.006585. Epub 2009 Apr 15.


The R6A-1 peptide binds to switch II of Galphai1 but is not a GDP-dissociation inhibitor.

Willard FS, Siderovski DP.

Biochem Biophys Res Commun. 2006 Jan 27;339(4):1107-12. Epub 2005 Dec 5.


An intramolecular contact in Galpha transducin that participates in maintaining its intrinsic GDP release rate.

Thomas TO, Bae H, Medkova M, Hamm HE.

Mol Cell Biol Res Commun. 2001 Sep;4(5):282-91.


Interdomain interactions regulate GDP release from heterotrimeric G proteins.

Remmers AE, Engel C, Liu M, Neubig RR.

Biochemistry. 1999 Oct 19;38(42):13795-800.


Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.

Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP.

Structure. 2005 Jul;13(7):1069-80.


Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.

Hamm HE, Meier SM, Liao G, Preininger AM.

Protein Sci. 2009 Nov;18(11):2326-35. doi: 10.1002/pro.243.


The carboxyl terminus of the Galpha-subunit is the latch for triggered activation of heterotrimeric G proteins.

Nanoff C, Koppensteiner R, Yang Q, Fuerst E, Ahorn H, Freissmuth M.

Mol Pharmacol. 2006 Jan;69(1):397-405. Epub 2005 Oct 6.


GoLoco motif proteins binding to Galpha(i1): insights from molecular simulations.

Khafizov K.

J Mol Model. 2009 Dec;15(12):1491-9. doi: 10.1007/s00894-009-0516-z. Epub 2009 May 14.


Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution.

Preininger AM, Kaya AI, Gilbert JA 3rd, Busenlehner LS, Armstrong RN, Hamm HE.

Biochemistry. 2012 Mar 6;51(9):1911-24. doi: 10.1021/bi201472c. Epub 2012 Feb 22.


Backbone resonance assignments for G protein α(i3) subunit in the GDP-bound state.

Mase Y, Yokogawa M, Osawa M, Shimada I.

Biomol NMR Assign. 2014 Oct;8(2):237-41. doi: 10.1007/s12104-013-9491-5. Epub 2013 Jun 15.

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