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Items: 1 to 20 of 72


Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

Liang S, Yang N, Pan Y, Deng S, Lin X, Yang X, Katsaros D, Roby KF, Hamilton TC, Connolly DC, Coukos G, Zhang L.

PLoS One. 2009;4(1):e4295. doi: 10.1371/journal.pone.0004295. Epub 2009 Jan 27.


Profiling of protein kinases in the neoplastic transformation of human ovarian surface epithelium.

Wong AS, Kim SO, Leung PC, Auersperg N, Pelech SL.

Gynecol Oncol. 2001 Aug;82(2):305-11.


Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.

Astanehe A, Arenillas D, Wasserman WW, Leung PC, Dunn SE, Davies BR, Mills GB, Auersperg N.

J Cell Sci. 2008 Mar 1;121(Pt 5):664-74. doi: 10.1242/jcs.013029. Epub 2008 Feb 12.


Type I to type II ovarian carcinoma progression: mutant Trp53 or Pik3ca confers a more aggressive tumor phenotype in a mouse model of ovarian cancer.

Wu R, Baker SJ, Hu TC, Norman KM, Fearon ER, Cho KR.

Am J Pathol. 2013 Apr;182(4):1391-9. doi: 10.1016/j.ajpath.2012.12.031.


PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation.

Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F.

Cancer Res. 2008 Oct 1;68(19):8127-36. doi: 10.1158/0008-5472.CAN-08-0755.


The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma.

Zhang L, Yang N, Katsaros D, Huang W, Park JW, Fracchioli S, Vezzani C, Rigault de la Longrais IA, Yao W, Rubin SC, Coukos G.

Cancer Res. 2003 Jul 15;63(14):4225-31.


PIK3CA alterations in Middle Eastern ovarian cancers.

Abubaker J, Bavi P, Al-Haqawi W, Jehan Z, Munkarah A, Uddin S, Al-Kuraya KS.

Mol Cancer. 2009 Jul 28;8:51. doi: 10.1186/1476-4598-8-51.


Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.

Tikoo A, Roh V, Montgomery KG, Ivetac I, Waring P, Pelzer R, Hare L, Shackleton M, Humbert P, Phillips WA.

PLoS One. 2012;7(5):e36924. doi: 10.1371/journal.pone.0036924. Epub 2012 May 30.


Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes.

Sasaki R, Narisawa-Saito M, Yugawa T, Fujita M, Tashiro H, Katabuchi H, Kiyono T.

Carcinogenesis. 2009 Mar;30(3):423-31. doi: 10.1093/carcin/bgp007. Epub 2009 Jan 6.


Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

Adams JR, Xu K, Liu JC, Agamez NM, Loch AJ, Wong RG, Wang W, Wright KL, Lane TF, Zacksenhaus E, Egan SE.

Cancer Res. 2011 Apr 1;71(7):2706-17. doi: 10.1158/0008-5472.CAN-10-0738. Epub 2011 Feb 15.


PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma.

Abe A, Minaguchi T, Ochi H, Onuki M, Okada S, Matsumoto K, Satoh T, Oki A, Yoshikawa H.

Hum Pathol. 2013 Feb;44(2):199-207. doi: 10.1016/j.humpath.2012.05.005. Epub 2012 Sep 3.


Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium.

Ahmed N, Maines-Bandiera S, Quinn MA, Unger WG, Dedhar S, Auersperg N.

Am J Physiol Cell Physiol. 2006 Jun;290(6):C1532-42. Epub 2006 Jan 4.


Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE).

Choi KC, Kang SK, Nathwani PS, Cheng KW, Auersperg N, Leung PC.

Mol Cell Endocrinol. 2001 Mar 28;174(1-2):99-110.


Proteome changes in ovarian epithelial cells derived from women with BRCA1 mutations and family histories of cancer.

Smith-Beckerman DM, Fung KW, Williams KE, Auersperg N, Godwin AK, Burlingame AL.

Mol Cell Proteomics. 2005 Feb;4(2):156-68. Epub 2004 Dec 9.


Non-invasive imaging of phosphoinositide-3-kinase-catalytic-subunit-alpha (PIK3CA) promoter modulation in small animal models.

Gaikwad SM, Gunjal L, Junutula AR, Astanehe A, Gambhir SS, Ray P.

PLoS One. 2013;8(2):e55971. doi: 10.1371/journal.pone.0055971. Epub 2013 Feb 5.

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