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Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.

Balbo S, Johnson CS, Kovi RC, James-Yi SA, O'Sullivan MG, Wang M, Le CT, Khariwala SS, Upadhyaya P, Hecht SS.

Carcinogenesis. 2014 Dec;35(12):2798-806. doi: 10.1093/carcin/bgu204. Epub 2014 Sep 30.


Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine.

Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS.

Chem Res Toxicol. 2007 Feb;20(2):246-56.


Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a carcinogenicity study.

Zhao L, Balbo S, Wang M, Upadhyaya P, Khariwala SS, Villalta PW, Hecht SS.

Chem Res Toxicol. 2013 Oct 21;26(10):1526-35. doi: 10.1021/tx400235x. Epub 2013 Sep 18.


Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine.

Zhang S, Wang M, Villalta PW, Lindgren BR, Lao Y, Hecht SS.

Chem Res Toxicol. 2009 May;22(5):949-56. doi: 10.1021/tx900040j.


Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.

Upadhyaya P, Kenney PM, Hochalter JB, Wang M, Hecht SS.

Carcinogenesis. 1999 Aug;20(8):1577-82.


Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA.

Upadhyaya P, Sturla SJ, Tretyakova N, Ziegel R, Villalta PW, Wang M, Hecht SS.

Chem Res Toxicol. 2003 Feb;16(2):180-90.


Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ma B, Villalta PW, Zarth AT, Kotandeniya D, Upadhyaya P, Stepanov I, Hecht SS.

Chem Res Toxicol. 2015 Nov 16;28(11):2151-9. doi: 10.1021/acs.chemrestox.5b00318. Epub 2015 Oct 12.


Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides.

Krishnegowda G, Sharma AK, Krzeminski J, Gowda AS, Lin JM, Desai D, Spratt TE, Amin S.

Chem Res Toxicol. 2011 Jun 20;24(6):960-7. doi: 10.1021/tx200127j. Epub 2011 May 5.

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