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Results: 1 to 20 of 138

1.

gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity.

Meng RD, Shelton CC, Li YM, Qin LX, Notterman D, Paty PB, Schwartz GK.

Cancer Res. 2009 Jan 15;69(2):573-82. doi: 10.1158/0008-5472.CAN-08-2088.

PMID:
19147571
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells.

Timme CR, Gruidl M, Yeatman TJ.

Apoptosis. 2013 Oct;18(10):1163-74. doi: 10.1007/s10495-013-0883-x.

PMID:
23887890
[PubMed - indexed for MEDLINE]
3.

Pterostilbene exerts antitumor activity via the Notch1 signaling pathway in human lung adenocarcinoma cells.

Yang Y, Yan X, Duan W, Yan J, Yi W, Liang Z, Wang N, Li Y, Chen W, Yu S, Jin Z, Yi D.

PLoS One. 2013 May 3;8(5):e62652. doi: 10.1371/journal.pone.0062652. Print 2013.

PMID:
23671619
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway.

Zhang H, Ye Y, Bai Z, Wang S.

Dig Dis Sci. 2008 Aug;53(8):2195-203. doi: 10.1007/s10620-007-0139-0. Epub 2008 Mar 5.

PMID:
18320325
[PubMed - indexed for MEDLINE]
5.

Antiproliferative effects of γ-secretase inhibitor, a Notch signalling inhibitor, in multiple myeloma cells and its molecular mechanism of action.

Hu J, Zhu X, Lu Q.

J Int Med Res. 2013 Aug;41(4):1017-26. doi: 10.1177/0300060513485912. Epub 2013 Jul 9.

PMID:
23839278
[PubMed - indexed for MEDLINE]
6.

Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.

Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C.

Mol Cancer Ther. 2010 Jan;9(1):202-10. doi: 10.1158/1535-7163.MCT-09-0771. Epub 2010 Jan 6.

PMID:
20053782
[PubMed - indexed for MEDLINE]
Free PMC Article
7.
8.

Alteration of the intrinsic apoptosis pathway is involved in Notch-induced chemoresistance to gemcitabine in pancreatic cancer.

Du X, Zhao YP, Zhang TP, Zhou L, Chen G, Wang TX, You L, Shu H.

Arch Med Res. 2014 Jan;45(1):15-20. doi: 10.1016/j.arcmed.2013.10.001. Epub 2013 Dec 5.

PMID:
24316112
[PubMed - indexed for MEDLINE]
9.

The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.

Ueno T, Endo S, Saito R, Hirose M, Hirai S, Suzuki H, Yamato K, Hyodo I.

Oncol Res. 2014;21(3):155-64. doi: 10.3727/096504013X13854886566598.

PMID:
24512730
[PubMed - indexed for MEDLINE]
10.

Notch-1 signaling regulates microglia activation via NF-κB pathway after hypoxic exposure in vivo and in vitro.

Yao L, Kan EM, Kaur C, Dheen ST, Hao A, Lu J, Ling EA.

PLoS One. 2013 Nov 6;8(11):e78439. doi: 10.1371/journal.pone.0078439. eCollection 2013.

PMID:
24223152
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.

Wei P, Walls M, Qiu M, Ding R, Denlinger RH, Wong A, Tsaparikos K, Jani JP, Hosea N, Sands M, Randolph S, Smeal T.

Mol Cancer Ther. 2010 Jun;9(6):1618-28. doi: 10.1158/1535-7163.MCT-10-0034. Epub 2010 Jun 8.

PMID:
20530712
[PubMed - indexed for MEDLINE]
Free Article
12.

Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.

Nemoto S, Nakamura M, Osawa Y, Kono S, Itoh Y, Okano Y, Murate T, Hara A, Ueda H, Nozawa Y, Banno Y.

J Biol Chem. 2009 Apr 17;284(16):10422-32. doi: 10.1074/jbc.M900735200. Epub 2009 Feb 24.

PMID:
19240026
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor.

Osipo C, Patel P, Rizzo P, Clementz AG, Hao L, Golde TE, Miele L.

Oncogene. 2008 Aug 28;27(37):5019-32. doi: 10.1038/onc.2008.149. Epub 2008 May 12.

PMID:
18469855
[PubMed - indexed for MEDLINE]
14.

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG.

Cancer Res. 2009 Apr 1;69(7):3060-8. doi: 10.1158/0008-5472.CAN-08-4295. Epub 2009 Mar 24.

PMID:
19318552
[PubMed - indexed for MEDLINE]
Free Article
15.

Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy.

Liu J, Mao Z, Huang J, Xie S, Liu T, Mao Z.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):670-5. doi: 10.1016/j.bbrc.2014.01.164. Epub 2014 Feb 3.

PMID:
24502949
[PubMed - indexed for MEDLINE]
16.

Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.

Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, Hardwick J, Scott M, Winter C, Bristow L, Elbi C, Reilly JF, Look T, Draetta G, Van der Ploeg L, Kohl NE, Strack PR, Majumder PK.

Br J Pharmacol. 2009 Nov;158(5):1183-95. doi: 10.1111/j.1476-5381.2009.00389.x. Epub 2009 Sep 23.

PMID:
19775282
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Down-regulation of Notch1 by gamma-secretase inhibition contributes to cell growth inhibition and apoptosis in ovarian cancer cells A2780.

Wang M, Wu L, Wang L, Xin X.

Biochem Biophys Res Commun. 2010 Feb 26;393(1):144-9. doi: 10.1016/j.bbrc.2010.01.103. Epub 2010 Feb 1.

PMID:
20117093
[PubMed - indexed for MEDLINE]
18.

NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.

Clementz AG, Rogowski A, Pandya K, Miele L, Osipo C.

Breast Cancer Res. 2011 Jun 14;13(3):R63. doi: 10.1186/bcr2900.

PMID:
21679465
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Silibinin induces cell death through reactive oxygen species-dependent downregulation of notch-1/ERK/Akt signaling in human breast cancer cells.

Kim TH, Woo JS, Kim YK, Kim KH.

J Pharmacol Exp Ther. 2014 May;349(2):268-78. doi: 10.1124/jpet.113.207563. Epub 2014 Jan 28.

PMID:
24472723
[PubMed - indexed for MEDLINE]
20.

Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke.

Arumugam TV, Cheng YL, Choi Y, Choi YH, Yang S, Yun YK, Park JS, Yang DK, Thundyil J, Gelderblom M, Karamyan VT, Tang SC, Chan SL, Magnus T, Sobey CG, Jo DG.

Mol Pharmacol. 2011 Jul;80(1):23-31. doi: 10.1124/mol.111.071076. Epub 2011 Mar 30. Erratum in: Mol Pharmacol. 2011 Sep;80(3):550.

PMID:
21450930
[PubMed - indexed for MEDLINE]
Free Article

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