Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 111

1.

Varespladib (A-002), a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/- mice.

Fraser H, Hislop C, Christie RM, Rick HL, Reidy CA, Chouinard ML, Eacho PI, Gould KE, Trias J.

J Cardiovasc Pharmacol. 2009 Jan;53(1):60-5. doi: 10.1097/FJC.0b013e318195bfbc.

PMID:
19129734
[PubMed - indexed for MEDLINE]
2.

The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002).

Shaposhnik Z, Wang X, Trias J, Fraser H, Lusis AJ.

J Lipid Res. 2009 Apr;50(4):623-9. doi: 10.1194/jlr.M800361-JLR200. Epub 2008 Nov 21.

PMID:
19029066
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Expression of type IIA secretory phospholipase A2 inhibits cholesteryl ester transfer protein activity in transgenic mice.

Hurt-Camejo E, Gautier T, Rosengren B, Dikkers A, Behrendt M, Grass DS, Rader DJ, Tietge UJ.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2707-14. doi: 10.1161/ATVBAHA.113.301410. Epub 2013 Oct 10.

PMID:
24115030
[PubMed - indexed for MEDLINE]
4.

Role of group II secretory phospholipase A2 in atherosclerosis: 2. Potential involvement of biologically active oxidized phospholipids.

Leitinger N, Watson AD, Hama SY, Ivandic B, Qiao JH, Huber J, Faull KF, Grass DS, Navab M, Fogelman AM, de Beer FC, Lusis AJ, Berliner JA.

Arterioscler Thromb Vasc Biol. 1999 May;19(5):1291-8.

PMID:
10323782
[PubMed - indexed for MEDLINE]
Free Article
5.

Secretory phospholipase A2 group V: lesion distribution, activation by arterial proteoglycans, and induction in aorta by a Western diet.

Rosengren B, Peilot H, Umaerus M, Jönsson-Rylander AC, Mattsson-Hultén L, Hallberg C, Cronet P, Rodriguez-Lee M, Hurt-Camejo E.

Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1579-85. Epub 2006 Apr 6.

PMID:
16601231
[PubMed - indexed for MEDLINE]
Free Article
6.

Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.

Ivandic B, Castellani LW, Wang XP, Qiao JH, Mehrabian M, Navab M, Fogelman AM, Grass DS, Swanson ME, de Beer MC, de Beer F, Lusis AJ.

Arterioscler Thromb Vasc Biol. 1999 May;19(5):1284-90.

PMID:
10323781
[PubMed - indexed for MEDLINE]
Free Article
7.

Simvastatin inhibits sPLA2 IIa expression in aorta and myocardium.

Wei-hua L, Chang-qing S, Qiang X, Rong W, Kai-min L.

Arch Med Res. 2009 Feb;40(2):67-72. doi: 10.1016/j.arcmed.2008.12.006.

PMID:
19237014
[PubMed - indexed for MEDLINE]
8.

The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice.

Joyce CW, Amar MJ, Lambert G, Vaisman BL, Paigen B, Najib-Fruchart J, Hoyt RF Jr, Neufeld ED, Remaley AT, Fredrickson DS, Brewer HB Jr, Santamarina-Fojo S.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):407-12. Epub 2001 Dec 18.

PMID:
11752403
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice.

Buday A, Orsy P, Godó M, Mózes M, Kökény G, Lacza Z, Koller A, Ungvári Z, Gross ML, Benyó Z, Hamar P.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H386-95. doi: 10.1152/ajpheart.01042.2009. Epub 2010 May 28.

PMID:
20511416
[PubMed - indexed for MEDLINE]
Free Article
10.

Secretory phospholipase A2: a multifaceted family of proatherogenic enzymes.

Rosenson RS, Gelb MH.

Curr Cardiol Rep. 2009 Nov;11(6):445-51. Review.

PMID:
19863869
[PubMed - indexed for MEDLINE]
11.

Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice.

Wassmann S, Czech T, van Eickels M, Fleming I, Böhm M, Nickenig G.

Circulation. 2004 Nov 9;110(19):3062-7. Epub 2004 Jul 26.

PMID:
15277329
[PubMed - indexed for MEDLINE]
Free Article
12.

Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress.

Tietge UJ, Pratico D, Ding T, Funk CD, Hildebrand RB, Van Berkel T, Van Eck M.

J Lipid Res. 2005 Aug;46(8):1604-14. Epub 2005 May 16.

PMID:
15897607
[PubMed - indexed for MEDLINE]
Free Article
13.

Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation.

Luchtefeld M, Bandlow N, Tietge UJ, Grote K, Pfeilschifter J, Kaszkin M, Beck S, Drexler H, Schieffer B.

Atherosclerosis. 2007 Sep;194(1):62-70. Epub 2006 Oct 27.

PMID:
17069818
[PubMed - indexed for MEDLINE]
14.

Group IVA phospholipase A2-associated production of MMP-9 in macrophages and formation of atherosclerotic lesions.

Ii H, Hontani N, Toshida I, Oka M, Sato T, Akiba S.

Biol Pharm Bull. 2008 Mar;31(3):363-8.

PMID:
18310893
[PubMed - indexed for MEDLINE]
Free Article
15.

Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice.

Tietge UJ, Maugeais C, Lund-Katz S, Grass D, deBeer FC, Rader DJ.

Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1213-8.

PMID:
12117740
[PubMed - indexed for MEDLINE]
Free Article
16.

Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E.

Yang H, Roberts LJ, Shi MJ, Zhou LC, Ballard BR, Richardson A, Guo ZM.

Circ Res. 2004 Nov 26;95(11):1075-81. Epub 2004 Nov 4.

PMID:
15528470
[PubMed - indexed for MEDLINE]
Free Article
17.

Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice.

Bostrom MA, Boyanovsky BB, Jordan CT, Wadsworth MP, Taatjes DJ, de Beer FC, Webb NR.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):600-6. Epub 2007 Jan 4.

PMID:
17204667
[PubMed - indexed for MEDLINE]
Free Article
18.

Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI.

Snyder DW, Bach NJ, Dillard RD, Draheim SE, Carlson DG, Fox N, Roehm NW, Armstrong CT, Chang CH, Hartley LW, Johnson LM, Roman CR, Smith AC, Song M, Fleisch JH.

J Pharmacol Exp Ther. 1999 Mar;288(3):1117-24.

PMID:
10027849
[PubMed - indexed for MEDLINE]
Free Article
19.

Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition.

Ghesquiere SA, Gijbels MJ, Anthonsen M, van Gorp PJ, van der Made I, Johansen B, Hofker MH, de Winther MP.

J Lipid Res. 2005 Feb;46(2):201-10. Epub 2004 Dec 1.

PMID:
15576846
[PubMed - indexed for MEDLINE]
Free Article
20.

A-002 (Varespladib), a phospholipase A2 inhibitor, reduces atherosclerosis in guinea pigs.

Leite JO, Vaishnav U, Puglisi M, Fraser H, Trias J, Fernandez ML.

BMC Cardiovasc Disord. 2009 Feb 17;9:7. doi: 10.1186/1471-2261-9-7.

PMID:
19222850
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk