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Items: 1 to 20 of 114


Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.

Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):450-5. doi: 10.1073/pnas.0808092106. Epub 2009 Jan 7.


Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.

Card PB, Erbel PJ, Gardner KH.

J Mol Biol. 2005 Oct 28;353(3):664-77. Epub 2005 Sep 6.


Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.

Partch CL, Gardner KH.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7739-44. doi: 10.1073/pnas.1101357108. Epub 2011 Apr 21.


Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.

Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH.

J Biol Chem. 2015 Mar 20;290(12):7707-21. doi: 10.1074/jbc.M114.632786. Epub 2015 Jan 27.


Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators.

Chapman-Smith A, Lutwyche JK, Whitelaw ML.

J Biol Chem. 2004 Feb 13;279(7):5353-62. Epub 2003 Nov 24.


Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR.

Hao N, Whitelaw ML, Shearwin KE, Dodd IB, Chapman-Smith A.

Nucleic Acids Res. 2011 May;39(9):3695-709. doi: 10.1093/nar/gkq1336. Epub 2011 Jan 17.


Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B.

Key J, Scheuermann TH, Anderson PC, Daggett V, Gardner KH.

J Am Chem Soc. 2009 Dec 9;131(48):17647-54. doi: 10.1021/ja9073062.


Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).

Partch CL, Card PB, Amezcua CA, Gardner KH.

J Biol Chem. 2009 May 29;284(22):15184-92. doi: 10.1074/jbc.M808479200. Epub 2009 Mar 26.


Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.

Erbel PJ, Card PB, Karakuzu O, Bruick RK, Gardner KH.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15504-9. Epub 2003 Dec 10.


Novel DNA binding by a basic helix-loop-helix protein. The role of the dioxin receptor PAS domain.

Chapman-Smith A, Whitelaw ML.

J Biol Chem. 2006 May 5;281(18):12535-45. Epub 2006 Mar 6.


Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.

Park EJ, Kong D, Fisher R, Cardellina J, Shoemaker RH, Melillo G.

Cell Cycle. 2006 Aug;5(16):1847-53. Epub 2006 Aug 15.


Structural integration in hypoxia-inducible factors.

Wu D, Potluri N, Lu J, Kim Y, Rastinejad F.

Nature. 2015 Aug 20;524(7565):303-8. doi: 10.1038/nature14883. Epub 2015 Aug 5.


Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding.

Masetti M, Falchi F, Recanatini M.

PLoS One. 2014 Apr 15;9(4):e94986. doi: 10.1371/journal.pone.0094986. eCollection 2014.


Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor.

Pongratz I, Antonsson C, Whitelaw ML, Poellinger L.

Mol Cell Biol. 1998 Jul;18(7):4079-88.


Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT).

Reisz-Porszasz S, Probst MR, Fukunaga BN, Hankinson O.

Mol Cell Biol. 1994 Sep;14(9):6075-86.


Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.

Gradin K, McGuire J, Wenger RH, Kvietikova I, fhitelaw ML, Toftgård R, Tora L, Gassmann M, Poellinger L.

Mol Cell Biol. 1996 Oct;16(10):5221-31.


The basic helix-loop-helix/PAS factor Sim is associated with hsp90. Implications for regulation by interaction with partner factors.

McGuire J, Coumailleau P, Whitelaw ML, Gustafsson JA, Poellinger L.

J Biol Chem. 1995 Dec 29;270(52):31353-7.

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