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Results: 1 to 20 of 237

1.

Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.

Reisman SA, Yeager RL, Yamamoto M, Klaassen CD.

Toxicol Sci. 2009 Mar;108(1):35-47. doi: 10.1093/toxsci/kfn267. Epub 2009 Jan 6.

PMID:
19129213
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.

Reisman SA, Csanaky IL, Aleksunes LM, Klaassen CD.

Toxicol Sci. 2009 May;109(1):31-40. doi: 10.1093/toxsci/kfp047. Epub 2009 Feb 26.

PMID:
19246624
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity.

Reisman SA, Csanaky IL, Yeager RL, Klaassen CD.

Toxicol Sci. 2009 May;109(1):24-30. doi: 10.1093/toxsci/kfp045. Epub 2009 Feb 26.

PMID:
19246623
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver.

Wu KC, Cui JY, Klaassen CD.

PLoS One. 2012;7(7):e39006. doi: 10.1371/journal.pone.0039006. Epub 2012 Jul 12.

PMID:
22808024
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Nrf2 protects against diquat-induced liver and lung injury.

Wu KC, Zhang Y, Klaassen CD.

Free Radic Res. 2012 Oct;46(10):1220-9. doi: 10.3109/10715762.2012.700709. Epub 2012 Jul 11.

PMID:
22762311
[PubMed - indexed for MEDLINE]
6.

Nrf2 protects against furosemide-induced hepatotoxicity.

Qu Q, Liu J, Zhou HH, Klaassen CD.

Toxicology. 2014 Oct 3;324:35-42. doi: 10.1016/j.tox.2014.02.008. Epub 2014 May 6.

PMID:
24813929
[PubMed - indexed for MEDLINE]
7.

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet.

Zhang YK, Yeager RL, Tanaka Y, Klaassen CD.

Toxicol Appl Pharmacol. 2010 Jun 15;245(3):326-34. doi: 10.1016/j.taap.2010.03.016. Epub 2010 Mar 27.

PMID:
20350562
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The Keap1-Nrf2 system as an in vivo sensor for electrophiles.

Uruno A, Motohashi H.

Nitric Oxide. 2011 Aug 1;25(2):153-60. doi: 10.1016/j.niox.2011.02.007. Epub 2011 Mar 6.

PMID:
21385624
[PubMed - indexed for MEDLINE]
9.

Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation.

Wu KC, Liu J, Klaassen CD.

Toxicol Appl Pharmacol. 2012 Aug 1;262(3):321-9. doi: 10.1016/j.taap.2012.05.010. Epub 2012 May 22.

PMID:
22627062
[PubMed - indexed for MEDLINE]
10.

Nrf2 activation prevents cadmium-induced acute liver injury.

Wu KC, Liu JJ, Klaassen CD.

Toxicol Appl Pharmacol. 2012 Aug 15;263(1):14-20. doi: 10.1016/j.taap.2012.05.017. Epub 2012 Jun 4.

PMID:
22677785
[PubMed - indexed for MEDLINE]
11.

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.

Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, Yamamoto M.

Biochem Biophys Res Commun. 2009 Nov 20;389(3):431-6. doi: 10.1016/j.bbrc.2009.08.156. Epub 2009 Sep 2.

PMID:
19732748
[PubMed - indexed for MEDLINE]
12.

Beneficial role of Nrf2 in regulating NADPH generation and consumption.

Wu KC, Cui JY, Klaassen CD.

Toxicol Sci. 2011 Oct;123(2):590-600. doi: 10.1093/toxsci/kfr183. Epub 2011 Jul 20.

PMID:
21775727
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver.

Klaassen CD, Reisman SA.

Toxicol Appl Pharmacol. 2010 Apr 1;244(1):57-65. doi: 10.1016/j.taap.2010.01.013. Epub 2010 Feb 1. Review.

PMID:
20122946
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Keap1 inhibition attenuates glomerulosclerosis.

Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T.

Nephrol Dial Transplant. 2014 Apr;29(4):783-91. doi: 10.1093/ndt/gfu002. Epub 2014 Feb 11.

PMID:
24523358
[PubMed - indexed for MEDLINE]
15.

Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.

Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J.

Free Radic Biol Med. 2012 Jan 15;52(2):462-72. doi: 10.1016/j.freeradbiomed.2011.10.453. Epub 2011 Oct 28.

PMID:
22138520
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1.

Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL.

J Biochem Mol Toxicol. 2011 Sep-Oct;25(5):320-9. doi: 10.1002/jbt.20392. Epub 2011 May 2.

PMID:
21538727
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW.

Carcinogenesis. 2009 Jun;30(6):1024-31. doi: 10.1093/carcin/bgp100. Epub 2009 Apr 21.

PMID:
19386581
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling.

Kanzaki H, Shinohara F, Kajiya M, Kodama T.

J Biol Chem. 2013 Aug 9;288(32):23009-20. doi: 10.1074/jbc.M113.478545. Epub 2013 Jun 25. Erratum in: J Biol Chem. 2014 Feb 28;289(9):5536.

PMID:
23801334
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.

Williamson TP, Johnson DA, Johnson JA.

Neurotoxicology. 2012 Jun;33(3):272-9. doi: 10.1016/j.neuro.2012.01.015. Epub 2012 Feb 9.

PMID:
22342405
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.

Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J.

J Gastroenterol. 2012 Aug;47(8):924-35. doi: 10.1007/s00535-012-0552-9. Epub 2012 Feb 28.

PMID:
22367278
[PubMed - indexed for MEDLINE]

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