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Items: 1 to 20 of 107


The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action.

Ayala JE, Bracy DP, James FD, Julien BM, Wasserman DH, Drucker DJ.

Endocrinology. 2009 Mar;150(3):1155-64. doi: 10.1210/en.2008-0945. Epub 2008 Nov 13.


Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance.

Ayala JE, Bracy DP, James FD, Burmeister MA, Wasserman DH, Drucker DJ.

Endocrinology. 2010 Oct;151(10):4678-87. doi: 10.1210/en.2010-0289. Epub 2010 Aug 4.


Regulation of glucose kinetics during exercise by the glucagon-like peptide-1 receptor.

Burmeister MA, Bracy DP, James FD, Holt RM, Ayala J, King EM, Wasserman DH, Drucker DJ, Ayala JE.

J Physiol. 2012 Oct 15;590(Pt 20):5245-55. doi: 10.1113/jphysiol.2012.234914. Epub 2012 Aug 13.


Insulin action in the double incretin receptor knockout mouse.

Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ.

Diabetes. 2008 Feb;57(2):288-97. Epub 2007 Oct 31.


Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice.

Burmeister MA, Ferre T, Ayala JE, King EM, Holt RM, Ayala JE.

Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E334-43. doi: 10.1152/ajpendo.00409.2011. Epub 2011 Nov 15.


Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.

Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ.

J Clin Invest. 2012 Jan;122(1):388-402. doi: 10.1172/JCI42497. Epub 2011 Dec 19.


Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.

Ali S, Lamont BJ, Charron MJ, Drucker DJ.

J Clin Invest. 2011 May;121(5):1917-29. doi: 10.1172/JCI43615. Epub 2011 Apr 11.


Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice.

Maida A, Lamont BJ, Cao X, Drucker DJ.

Diabetologia. 2011 Feb;54(2):339-49. doi: 10.1007/s00125-010-1937-z. Epub 2010 Oct 23.


Long-term metabolic benefits of exenatide in mice are mediated solely via the known glucagon-like peptide 1 receptor.

Tatarkiewicz K, Sablan EJ, Polizzi CJ, Villescaz C, Parkes DG.

Am J Physiol Regul Integr Comp Physiol. 2014 Apr 1;306(7):R490-8. doi: 10.1152/ajpregu.00495.2013. Epub 2014 Jan 29.


Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.

Knauf C, Cani PD, Perrin C, Iglesias MA, Maury JF, Bernard E, Benhamed F, Grémeaux T, Drucker DJ, Kahn CR, Girard J, Tanti JF, Delzenne NM, Postic C, Burcelin R.

J Clin Invest. 2005 Dec;115(12):3554-63.


Increased submaximal insulin-stimulated glucose uptake in mouse skeletal muscle after treadmill exercise.

Hamada T, Arias EB, Cartee GD.

J Appl Physiol (1985). 2006 Nov;101(5):1368-76. Epub 2006 Jun 29.


Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice.

Maida A, Hansotia T, Longuet C, Seino Y, Drucker DJ.

Gastroenterology. 2009 Dec;137(6):2146-57. doi: 10.1053/j.gastro.2009.09.004. Epub 2009 Sep 17.


Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice.

Flock GB, Cao X, Maziarz M, Drucker DJ.

Diabetes. 2013 Jan;62(1):283-90. doi: 10.2337/db12-0601. Epub 2012 Aug 29.


GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms.

Flock G, Holland D, Seino Y, Drucker DJ.

Endocrinology. 2011 Feb;152(2):374-83. doi: 10.1210/en.2010-1047. Epub 2010 Nov 10.


The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.

Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA.

Cell Metab. 2014 Jun 3;19(6):1050-7. doi: 10.1016/j.cmet.2014.04.005. Epub 2014 May 15.


Differential effects of oxyntomodulin and GLP-1 on glucose metabolism.

Du X, Kosinski JR, Lao J, Shen X, Petrov A, Chicchi GG, Eiermann GJ, Pocai A.

Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E265-71. doi: 10.1152/ajpendo.00142.2012. Epub 2012 May 22.


High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle.

Tanaka S, Hayashi T, Toyoda T, Hamada T, Shimizu Y, Hirata M, Ebihara K, Masuzaki H, Hosoda K, Fushiki T, Nakao K.

Metabolism. 2007 Dec;56(12):1719-28.


Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice.

Maarbjerg SJ, Jørgensen SB, Rose AJ, Jeppesen J, Jensen TE, Treebak JT, Birk JB, Schjerling P, Wojtaszewski JF, Richter EA.

Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E924-34. doi: 10.1152/ajpendo.90653.2008. Epub 2009 Aug 4.


Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice.

Wojtaszewski JF, Higaki Y, Hirshman MF, Michael MD, Dufresne SD, Kahn CR, Goodyear LJ.

J Clin Invest. 1999 Nov;104(9):1257-64.

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