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Items: 1 to 20 of 124

1.

Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

Madani N, Schön A, Princiotto AM, Lalonde JM, Courter JR, Soeta T, Ng D, Wang L, Brower ET, Xiang SH, Kwon YD, Huang CC, Wyatt R, Kwong PD, Freire E, Smith AB 3rd, Sodroski J.

Structure. 2008 Nov 12;16(11):1689-701. doi: 10.1016/j.str.2008.09.005.

2.

Plugging gp120s cavity.

Repik A, Clapham PR.

Structure. 2008 Nov 12;16(11):1603-4. doi: 10.1016/j.str.2008.10.003.

3.

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

Schön A, Madani N, Klein JC, Hubicki A, Ng D, Yang X, Smith AB 3rd, Sodroski J, Freire E.

Biochemistry. 2006 Sep 12;45(36):10973-80.

4.

Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state.

Haim H, Si Z, Madani N, Wang L, Courter JR, Princiotto A, Kassa A, DeGrace M, McGee-Estrada K, Mefford M, Gabuzda D, Smith AB 3rd, Sodroski J.

PLoS Pathog. 2009 Apr;5(4):e1000360. doi: 10.1371/journal.ppat.1000360. Epub 2009 Apr 3.

5.

Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein.

Hoffman TL, LaBranche CC, Zhang W, Canziani G, Robinson J, Chaiken I, Hoxie JA, Doms RW.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6359-64.

6.

Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.

Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, LaLonde JM, Smith AB 3rd.

Acc Chem Res. 2014 Apr 15;47(4):1228-37. doi: 10.1021/ar4002735. Epub 2014 Feb 6. Review.

7.

CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization.

Sullivan N, Sun Y, Sattentau Q, Thali M, Wu D, Denisova G, Gershoni J, Robinson J, Moore J, Sodroski J.

J Virol. 1998 Jun;72(6):4694-703.

8.

Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4.

Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK.

Virology. 2005 Sep 1;339(2):213-25.

9.

Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.

Xiang SH, Kwong PD, Gupta R, Rizzuto CD, Casper DJ, Wyatt R, Wang L, Hendrickson WA, Doyle ML, Sodroski J.

J Virol. 2002 Oct;76(19):9888-99.

10.

Naturally occurring variability in the envelope glycoprotein of HIV-1 and development of cell entry inhibitors.

Brower ET, Schön A, Freire E.

Biochemistry. 2010 Mar 23;49(11):2359-67. doi: 10.1021/bi1000933.

11.
12.

Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex.

Fouts TR, Tuskan R, Godfrey K, Reitz M, Hone D, Lewis GK, DeVico AL.

J Virol. 2000 Dec;74(24):11427-36.

13.

A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.

Rizzuto CD, Wyatt R, Hernández-Ramos N, Sun Y, Kwong PD, Hendrickson WA, Sodroski J.

Science. 1998 Jun 19;280(5371):1949-53.

14.

Dynamic domains and geometrical properties of HIV-1 gp120 during conformational changes induced by CD4 binding.

Liu SQ, Liu SX, Fu YX.

J Mol Model. 2007 Mar;13(3):411-24. Epub 2006 Nov 28.

PMID:
17131136
15.

Enhanced dynamics of HIV gp120 glycoprotein by small molecule binding.

Shrivastava I, LaLonde JM.

Biochemistry. 2011 May 17;50(19):4173-83. doi: 10.1021/bi2002218. Epub 2011 Apr 21.

16.

Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain.

Kassa A, Madani N, Schön A, Haim H, Finzi A, Xiang SH, Wang L, Princiotto A, Pancera M, Courter J, Smith AB 3rd, Freire E, Kwong PD, Sodroski J.

J Virol. 2009 Sep;83(17):8364-78. doi: 10.1128/JVI.00594-09. Epub 2009 Jun 17.

17.

Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues.

Yu X, Talukder P, Bhattacharya C, Fahmi NE, Lines JA, Dedkova LM, LaBaer J, Hecht SM, Chen S.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5699-703. doi: 10.1016/j.bmcl.2014.10.058. Epub 2014 Oct 22.

PMID:
25453804
18.

Atomic insight into the CD4 binding-induced conformational changes in HIV-1 gp120.

Hsu ST, Bonvin AM.

Proteins. 2004 May 15;55(3):582-93.

PMID:
15103622
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