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Results: 1 to 20 of 229

1.

Conversion of human choriogonadotropin into a follitropin by protein engineering.

Campbell RK, Dean-Emig DM, Moyle WR.

Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):760-4.

PMID:
1899483
[PubMed - indexed for MEDLINE]
Free PMC Article
3.
4.

The groove between the alpha- and beta-subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding.

Cosowsky L, Rao SN, Macdonald GJ, Papkoff H, Campbell RK, Moyle WR.

J Biol Chem. 1995 Aug 25;270(34):20011-9.

PMID:
7650019
[PubMed - indexed for MEDLINE]
Free Article
5.

Co-evolution of ligand-receptor pairs.

Moyle WR, Campbell RK, Myers RV, Bernard MP, Han Y, Wang X.

Nature. 1994 Mar 17;368(6468):251-5.

PMID:
8145825
[PubMed - indexed for MEDLINE]
6.

Site-directed alanine mutagenesis of Phe33, Arg35, and Arg42-Ser43-Lys44 in the human gonadotropin alpha-subunit.

Liu C, Roth KE, Shepard BA, Shaffer JB, Dias JA.

J Biol Chem. 1993 Oct 15;268(29):21613-7.

PMID:
7691814
[PubMed - indexed for MEDLINE]
Free Article
7.

Bifunctional hCG analogs adopt different conformations in LH and FSH receptor complexes.

Wang Y, Bernard MP, Moyle WR.

Mol Cell Endocrinol. 2000 Dec 22;170(1-2):67-77.

PMID:
11162891
[PubMed - indexed for MEDLINE]
8.

Follitropin conformational stability mediated by loop 2 beta effects follitropin-receptor interaction.

Roth KE, Dias JA.

Biochemistry. 1996 Jun 18;35(24):7928-35.

PMID:
8672495
[PubMed - indexed for MEDLINE]
9.

beta-Subunit 102-104 residues are crucial to confer FSH activity to equine LH/CG but are not sufficient to confer FSH activity to human CG.

Chopineau M, Martinat N, Galet C, Guillou F, Combarnous Y.

J Endocrinol. 2001 Apr;169(1):55-63.

PMID:
11250646
[PubMed - indexed for MEDLINE]
Free Article
10.

Opposite contribution of two ligand-selective determinants in the N-terminal hormone-binding exodomain of human gonadotropin receptors.

Vischer HF, Granneman JC, Bogerd J.

Mol Endocrinol. 2003 Oct;17(10):1972-81. Epub 2003 Jul 17.

PMID:
12869592
[PubMed - indexed for MEDLINE]
11.

Identification of a follicle-stimulating hormone receptor-binding region in hFSH-beta-(81-95) using synthetic peptides.

Santa Coloma TA, Reichert LE Jr.

J Biol Chem. 1990 Mar 25;265(9):5037-42.

PMID:
1690733
[PubMed - indexed for MEDLINE]
Free Article
12.
13.

Effect of modification of all loop regions in the alpha- and beta-subunits of human choriogonadotropin on its signal transduction activity.

Shao K, Purohit S, Bahl OP.

Mol Cell Endocrinol. 1996 Sep 18;122(2):173-82.

PMID:
8902847
[PubMed - indexed for MEDLINE]
14.

The human follitropin alpha-subunit C terminus collaborates with a beta-subunit cystine noose and an alpha-subunit loop to assemble a receptor-binding domain competent for signal transduction.

Arnold CJ, Liu C, Lindau-Shepard B, Losavio ML, Patrascu MT, Dias JA.

Biochemistry. 1998 Feb 17;37(7):1762-8.

PMID:
9485301
[PubMed - indexed for MEDLINE]
15.

A synthetic peptide corresponding to glycoprotein hormone alpha subunit residues 32-46 inhibits gonadotropin binding to receptor.

Leng N, Grasso P, Deziel MR, Reichert LE Jr.

Pept Res. 1995 Sep-Oct;8(5):272-7.

PMID:
8589549
[PubMed - indexed for MEDLINE]
16.

Ligand selectivity of gonadotropin receptors. Role of the beta-strands of extracellular leucine-rich repeats 3 and 6 of the human luteinizing hormone receptor.

Vischer HF, Granneman JC, Noordam MJ, Mosselman S, Bogerd J.

J Biol Chem. 2003 May 2;278(18):15505-13. Epub 2003 Feb 21.

PMID:
12598521
[PubMed - indexed for MEDLINE]
Free Article
17.

Functionally distinct agonist and receptor-binding regions in human chorionic gonadotropin. Development of a tertiary structure model.

Willey KP, Leidenberger F.

J Biol Chem. 1989 Nov 25;264(33):19716-29.

PMID:
2584190
[PubMed - indexed for MEDLINE]
Free Article
18.

A receptor binding site identified in the region 81-95 of the beta-subunit of human luteinizing hormone (LH) and chorionic gonadotropin (hCG).

Morbeck DE, Roche PC, Keutmann HT, McCormick DJ.

Mol Cell Endocrinol. 1993 Nov;97(1-2):173-81.

PMID:
8143901
[PubMed - indexed for MEDLINE]
19.

Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/luteinizing hormone beta subunit chimeras and mutants.

Moyle WR, Matzuk MM, Campbell RK, Cogliani E, Dean-Emig DM, Krichevsky A, Barnett RW, Boime I.

J Biol Chem. 1990 May 25;265(15):8511-8.

PMID:
1692832
[PubMed - indexed for MEDLINE]
Free Article
20.

Role of the beta 93-100 determinant loop sequence in receptor binding and biological activity of human luteinizing hormone and chorionic gonadotropin.

Keutmann HT, Mason KA, Kitzmann K, Ryan RJ.

Mol Endocrinol. 1989 Mar;3(3):526-31.

PMID:
2747659
[PubMed - indexed for MEDLINE]

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