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Results: 1 to 20 of 99

1.

The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.

Xue M, Ma C, Craig TK, Rosenmund C, Rizo J.

Nat Struct Mol Biol. 2008 Nov;15(11):1160-8. doi: 10.1038/nsmb.1508. Epub 2008 Oct 26.

PMID:
18953334
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.

Dai H, Shen N, Araç D, Rizo J.

J Mol Biol. 2007 Mar 30;367(3):848-63. Epub 2007 Jan 23.

PMID:
17320903
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats.

Yamamoto Y, Mochida S, Miyazaki N, Kawai K, Fujikura K, Kurooka T, Iwasaki K, Sakisaka T.

J Biol Chem. 2010 Dec 24;285(52):40943-55. doi: 10.1074/jbc.M110.156893. Epub 2010 Oct 26.

PMID:
20978127
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.

Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J.

PLoS One. 2010 Sep 2;5(9). pii: e12544. doi: 10.1371/journal.pone.0012544.

PMID:
20824061
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.

Groffen AJ, Martens S, Díez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M.

Science. 2010 Mar 26;327(5973):1614-8. doi: 10.1126/science.1183765. Epub 2010 Feb 11. Erratum in: Science. 2010 May 7;328(5979):690.

PMID:
20150444
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1.

Rhee JS, Li LY, Shin OH, Rah JC, Rizo J, Südhof TC, Rosenmund C.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18664-9. Epub 2005 Dec 13.

PMID:
16352718
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation.

van den Bogaart G, Thutupalli S, Risselada JH, Meyenberg K, Holt M, Riedel D, Diederichsen U, Herminghaus S, Grubmüller H, Jahn R.

Nat Struct Mol Biol. 2011 Jun 5;18(7):805-12. doi: 10.1038/nsmb.2061.

PMID:
21642968
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo.

Paddock BE, Wang Z, Biela LM, Chen K, Getzy MD, Striegel A, Richmond JE, Chapman ER, Featherstone DE, Reist NE.

J Neurosci. 2011 Feb 9;31(6):2248-57. doi: 10.1523/JNEUROSCI.3153-09.2011.

PMID:
21307261
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.

Masumoto T, Suzuki K, Ohmori I, Michiue H, Tomizawa K, Fujimura A, Nishiki T, Matsui H.

Mol Cell Neurosci. 2012 Jan;49(1):1-8. doi: 10.1016/j.mcn.2011.09.007. Epub 2011 Oct 8.

PMID:
22008253
[PubMed - indexed for MEDLINE]
10.

Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion.

Vrljic M, Strop P, Ernst JA, Sutton RB, Chu S, Brunger AT.

Nat Struct Mol Biol. 2010 Mar;17(3):325-31. doi: 10.1038/nsmb.1764. Epub 2010 Feb 21.

PMID:
20173762
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1.

Lee HK, Yang Y, Su Z, Hyeon C, Lee TS, Lee HW, Kweon DH, Shin YK, Yoon TY.

Science. 2010 May 7;328(5979):760-3. doi: 10.1126/science.1187722.

PMID:
20448186
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Mechanism and function of synaptotagmin-mediated membrane apposition.

Hui E, Gaffaney JD, Wang Z, Johnson CP, Evans CS, Chapman ER.

Nat Struct Mol Biol. 2011 Jun 5;18(7):813-21. doi: 10.1038/nsmb.2075.

PMID:
21642967
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids.

Stein A, Radhakrishnan A, Riedel D, Fasshauer D, Jahn R.

Nat Struct Mol Biol. 2007 Oct;14(10):904-11. Epub 2007 Sep 23.

PMID:
17891149
[PubMed - indexed for MEDLINE]
14.

Dual roles of the C2B domain of synaptotagmin I in synchronizing Ca2+-dependent neurotransmitter release.

Nishiki T, Augustine GJ.

J Neurosci. 2004 Sep 29;24(39):8542-50.

PMID:
15456828
[PubMed - indexed for MEDLINE]
Free Article
15.

Distinct domains of complexin I differentially regulate neurotransmitter release.

Xue M, Reim K, Chen X, Chao HT, Deng H, Rizo J, Brose N, Rosenmund C.

Nat Struct Mol Biol. 2007 Oct;14(10):949-58. Epub 2007 Sep 9.

PMID:
17828276
[PubMed - indexed for MEDLINE]
16.
17.

Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo.

Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE.

J Neurosci. 2008 Jul 23;28(30):7458-66. doi: 10.1523/JNEUROSCI.0197-08.2008.

PMID:
18650324
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate.

Radhakrishnan A, Stein A, Jahn R, Fasshauer D.

J Biol Chem. 2009 Sep 18;284(38):25749-60. doi: 10.1074/jbc.M109.042499. Epub 2009 Jul 24.

PMID:
19632983
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy.

Zhou A, Brewer KD, Rizo J.

Biochemistry. 2013 May 21;52(20):3446-56. doi: 10.1021/bi400230u. Epub 2013 May 7.

PMID:
23617808
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.

Shin OH, Xu J, Rizo J, Südhof TC.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16469-74. doi: 10.1073/pnas.0908798106. Epub 2009 Sep 4.

PMID:
19805322
[PubMed - indexed for MEDLINE]
Free PMC Article

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