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Results: 1 to 20 of 113

1.

A short Nur77-derived peptide converts Bcl-2 from a protector to a killer.

Kolluri SK, Zhu X, Zhou X, Lin B, Chen Y, Sun K, Tian X, Town J, Cao X, Lin F, Zhai D, Kitada S, Luciano F, O'Donnell E, Cao Y, He F, Lin J, Reed JC, Satterthwait AC, Zhang XK.

Cancer Cell. 2008 Oct 7;14(4):285-98. doi: 10.1016/j.ccr.2008.09.002.

PMID:
18835031
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77-based mechanism.

Chen J, Fiskus W, Eaton K, Fernandez P, Wang Y, Rao R, Lee P, Joshi R, Yang Y, Kolhe R, Balusu R, Chappa P, Natarajan K, Jillella A, Atadja P, Bhalla KN.

Blood. 2009 Apr 23;113(17):4038-48. doi: 10.1182/blood-2008-08-176024. Epub 2008 Dec 12.

PMID:
19074726
[PubMed - indexed for MEDLINE]
Free Article
3.

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.

Thompson J, Winoto A.

J Exp Med. 2008 May 12;205(5):1029-36. doi: 10.1084/jem.20080101. Epub 2008 Apr 28.

PMID:
18443228
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.

Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK.

Cell. 2004 Feb 20;116(4):527-40.

PMID:
14980220
[PubMed - indexed for MEDLINE]
Free Article
6.

Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.

Ferlini C, Cicchillitti L, Raspaglio G, Bartollino S, Cimitan S, Bertucci C, Mozzetti S, Gallo D, Persico M, Fattorusso C, Campiani G, Scambia G.

Cancer Res. 2009 Sep 1;69(17):6906-14. doi: 10.1158/0008-5472.CAN-09-0540. Epub 2009 Aug 11.

PMID:
19671798
[PubMed - indexed for MEDLINE]
Free Article
7.

Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins.

Moreau C, Cartron PF, Hunt A, Meflah K, Green DR, Evan G, Vallette FM, Juin P.

J Biol Chem. 2003 May 23;278(21):19426-35. Epub 2003 Mar 17.

PMID:
12642586
[PubMed - indexed for MEDLINE]
Free Article
8.
9.

Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.

Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S.

J Biol Chem. 2005 Jul 1;280(26):24903-14. Epub 2005 May 3.

PMID:
15871945
[PubMed - indexed for MEDLINE]
Free Article
10.

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell.

Tian D, Das SG, Doshi JM, Peng J, Lin J, Xing C.

Cancer Lett. 2008 Feb 8;259(2):198-208. Epub 2007 Nov 26.

PMID:
18037229
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.

Science. 2007 Feb 9;315(5813):856-9.

PMID:
17289999
[PubMed - indexed for MEDLINE]
Free Article
12.

Sequence and helicity requirements for the proapoptotic activity of Bax BH3 peptides.

Shangary S, Oliver CL, Tillman TS, Cascio M, Johnson DE.

Mol Cancer Ther. 2004 Nov;3(11):1343-54.

PMID:
15542773
[PubMed - indexed for MEDLINE]
Free Article
13.

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4.

Huang DC, Adams JM, Cory S.

EMBO J. 1998 Feb 16;17(4):1029-39.

PMID:
9463381
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma.

Luciano F, Krajewska M, Ortiz-Rubio P, Krajewski S, Zhai D, Faustin B, Bruey JM, Bailly-Maitre B, Lichtenstein A, Kolluri SK, Satterthwait AC, Zhang XK, Reed JC.

Blood. 2007 May 1;109(9):3849-55. Epub 2007 Jan 16. Erratum in: Blood. 2009 Feb 12;113(7):1613.

PMID:
17227826
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Small molecule inhibition of the Bcl-X(L)-BH3 protein-protein interaction: proof-of-concept of an in vivo chemopotentiator ABT-737.

Stauffer SR.

Curr Top Med Chem. 2007;7(10):961-5. Review.

PMID:
17508927
[PubMed - indexed for MEDLINE]
16.

Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax.

Werner AB, de Vries E, Tait SW, Bontjer I, Borst J.

J Biol Chem. 2002 Jun 21;277(25):22781-8. Epub 2002 Apr 19.

PMID:
11929871
[PubMed - indexed for MEDLINE]
Free Article
17.

Peptide screening to knockdown Bcl-2's anti-apoptotic activity: implications in cancer treatment.

Raghav PK, Verma YK, Gangenahalli GU.

Int J Biol Macromol. 2012 Apr 1;50(3):796-814. doi: 10.1016/j.ijbiomac.2011.11.021. Epub 2011 Dec 1.

PMID:
22155216
[PubMed - indexed for MEDLINE]
18.

Involvement of both extrinsic and intrinsic apoptotic pathways in apoptosis induced by genistein in human cervical cancer cells.

Kim SH, Kim SH, Lee SC, Song YS.

Ann N Y Acad Sci. 2009 Aug;1171:196-201. doi: 10.1111/j.1749-6632.2009.04902.x.

PMID:
19723056
[PubMed - indexed for MEDLINE]
19.

Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).

Vieira HL, Boya P, Cohen I, El Hamel C, Haouzi D, Druillenec S, Belzacq AS, Brenner C, Roques B, Kroemer G.

Oncogene. 2002 Mar 27;21(13):1963-77.

PMID:
11960369
[PubMed - indexed for MEDLINE]
Free Article
20.

Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways.

Zhang YW, Jiang XX, Chen QS, Shi WY, Wang L, Sun HD, Shen ZX, Chen Z, Chen SJ, Zhao WL.

Exp Hematol. 2010 Mar;38(3):191-201. doi: 10.1016/j.exphem.2009.12.005. Epub 2010 Jan 4.

PMID:
20045442
[PubMed - indexed for MEDLINE]

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