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Items: 1 to 20 of 117

1.

Short hairpin RNA interference therapy for ischemic heart disease.

Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC.

Circulation. 2008 Sep 30;118(14 Suppl):S226-33. doi: 10.1161/CIRCULATIONAHA.107.760785.

2.

Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia.

Huang M, Wu JC.

Methods Mol Biol. 2011;709:211-21. doi: 10.1007/978-1-61737-982-6_13.

3.

Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction.

Huang M, Nguyen P, Jia F, Hu S, Gong Y, de Almeida PE, Wang L, Nag D, Kay MA, Giaccia AJ, Robbins RC, Wu JC.

Circulation. 2011 Sep 13;124(11 Suppl):S46-54. doi: 10.1161/CIRCULATIONAHA.110.014019.

4.

Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia.

Lijkwan MA, Hellingman AA, Bos EJ, van der Bogt KE, Huang M, Kooreman NG, de Vries MR, Peters HA, Robbins RC, Hamming JF, Quax PH, Wu JC.

Hum Gene Ther. 2014 Jan;25(1):41-9. doi: 10.1089/hum.2013.110. Epub 2014 Jan 7.

5.

Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.

Wu S, Nishiyama N, Kano MR, Morishita Y, Miyazono K, Itaka K, Chung UI, Kataoka K.

Mol Ther. 2008 Jul;16(7):1227-34. doi: 10.1038/mt.2008.90. Epub 2008 May 20.

PMID:
18500250
6.

Prolyl hydroxylase domain protein 2 silencing enhances the survival and paracrine function of transplanted adipose-derived stem cells in infarcted myocardium.

Wang WE, Yang D, Li L, Wang W, Peng Y, Chen C, Chen P, Xia X, Wang H, Jiang J, Liao Q, Li Y, Xie G, Huang H, Guo Y, Ye L, Duan DD, Chen X, Houser SR, Zeng C.

Circ Res. 2013 Jul 19;113(3):288-300. doi: 10.1161/CIRCRESAHA.113.300929. Epub 2013 May 21.

7.

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

Stolze IP, Tian YM, Appelhoff RJ, Turley H, Wykoff CC, Gleadle JM, Ratcliffe PJ.

J Biol Chem. 2004 Oct 8;279(41):42719-25. Epub 2004 Aug 9. Erratum in: J Biol Chem. 2004 Dec 24;279(52):54974.

8.

Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.

Loinard C, Ginouvès A, Vilar J, Cochain C, Zouggari Y, Recalde A, Duriez M, Lévy BI, Pouysségur J, Berra E, Silvestre JS.

Circulation. 2009 Jul 7;120(1):50-9. doi: 10.1161/CIRCULATIONAHA.108.813303. Epub 2009 Jun 22.

9.

Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury.

Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA 3rd.

Circ Res. 2006 Jan 6;98(1):133-40. Epub 2005 Nov 23.

10.

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

Willam C, Maxwell PH, Nichols L, Lygate C, Tian YM, Bernhardt W, Wiesener M, Ratcliffe PJ, Eckardt KU, Pugh CW.

J Mol Cell Cardiol. 2006 Jul;41(1):68-77.

PMID:
16765982
11.

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.

Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC.

J Cell Biochem. 2004 Jun 1;92(3):491-501. Erratum in: J Cell Biochem. 2004 Oct 15;93(3):639.

PMID:
15156561
12.

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

Takeda K, Cowan A, Fong GH.

Circulation. 2007 Aug 14;116(7):774-81. Epub 2007 Jul 23.

13.

Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation.

Takeda K, Fong GH.

Hypertension. 2007 Jan;49(1):178-84. Epub 2006 Nov 13.

14.

Inhibition of hypoxia-induced retinal neovascularization in mice with short hairpin RNA targeting Rac1, possibly via blockading redox signaling.

Zhang XZ, Huang X, Qiao JH, Zhang JJ, Zhang MX.

Exp Eye Res. 2011 Jun;92(6):473-81. doi: 10.1016/j.exer.2011.03.005. Epub 2011 Mar 22.

PMID:
21414312
15.

Mesenchymal stem cells modified with miR-126 release angiogenic factors and activate Notch ligand Delta-like-4, enhancing ischemic angiogenesis and cell survival.

Huang F, Zhu X, Hu XQ, Fang ZF, Tang L, Lu XL, Zhou SH.

Int J Mol Med. 2013 Feb;31(2):484-92. doi: 10.3892/ijmm.2012.1200. Epub 2012 Dec 3.

PMID:
23229021
16.

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.

EMBO J. 2003 Aug 15;22(16):4082-90.

17.

Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM.

Clin Cancer Res. 2006 Feb 15;12(4):1080-7.

18.

Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis.

Bordoli MR, Stiehl DP, Borsig L, Kristiansen G, Hausladen S, Schraml P, Wenger RH, Camenisch G.

Oncogene. 2011 Feb 3;30(5):548-60. doi: 10.1038/onc.2010.433. Epub 2010 Sep 20.

PMID:
20856199
19.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM.

J Biol Chem. 2004 Sep 10;279(37):38458-65. Epub 2004 Jul 7.

20.

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element.

Metzen E, Stiehl DP, Doege K, Marxsen JH, Hellwig-Bürgel T, Jelkmann W.

Biochem J. 2005 May 1;387(Pt 3):711-7.

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