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15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.

Zhu H, Glasgow W, George MD, Chrysovergis K, Olden K, Roberts JD, Eling T.

Int J Cancer. 2008 Dec 15;123(12):2741-9. doi: 10.1002/ijc.23855.


Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells.

Kim JS, Baek SJ, Bottone FG Jr, Sali T, Eling TE.

Mol Cancer Res. 2005 Sep;3(9):511-7.


The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds.

Yoshinaga M, Murao H, Kitamura Y, Koga K, Tsuruta S, Igarashi H, Nakamura K, Takayanagi R.

J Gastroenterol Hepatol. 2007 Dec;22(12):2324-9. Epub 2007 Jun 7.


Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription.

Torosyan Y, Dobi A, Naga S, Mezhevaya K, Glasman M, Norris C, Jiang G, Mueller G, Pollard H, Srivastava M.

Cancer Res. 2006 Oct 1;66(19):9609-16.


15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Shureiqi I, Chen D, Lee JJ, Yang P, Newman RA, Brenner DE, Lotan R, Fischer SM, Lippman SM.

J Natl Cancer Inst. 2000 Jul 19;92(14):1136-42.


Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene.

Shankaranarayanan P, Chaitidis P, Kühn H, Nigam S.

J Biol Chem. 2001 Nov 16;276(46):42753-60. Epub 2001 Aug 16.


Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells.

Boudreau HE, Casterline BW, Burke DJ, Leto TL.

Br J Cancer. 2014 May 13;110(10):2569-82. doi: 10.1038/bjc.2014.165. Epub 2014 Apr 8.


Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer.

Heslin MJ, Hawkins A, Boedefeld W, Arnoletti JP, Frolov A, Soong R, Urist MM, Bland KI.

Ann Surg. 2005 Jun;241(6):941-6; discussion 946-7.


Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.

Das KC, Dashnamoorthy R.

Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L87-97. Epub 2003 Sep 5.


PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.

Hu F, Gartenhaus RB, Eichberg D, Liu Z, Fang HB, Rapoport AP.

Oncogene. 2010 Oct 7;29(40):5464-74. doi: 10.1038/onc.2010.275. Epub 2010 Jul 12.


Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.

Achanta G, Pelicano H, Feng L, Plunkett W, Huang P.

Cancer Res. 2001 Dec 15;61(24):8723-9.


AMPK-beta1 subunit is a p53-independent stress responsive protein that inhibits tumor cell growth upon forced expression.

Li J, Jiang P, Robinson M, Lawrence TS, Sun Y.

Carcinogenesis. 2003 May;24(5):827-34.


15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.

Yoshinaga M, Buchanan FG, DuBois RN.

Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):111-22.


Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.

Moussalli MJ, Wu Y, Zuo X, Yang XL, Wistuba II, Raso MG, Morris JS, Bowser JL, Minna JD, Lotan R, Shureiqi I.

Cancer Prev Res (Phila). 2011 Dec;4(12):1961-72. doi: 10.1158/1940-6207.CAPR-10-0280. Epub 2011 Aug 31.


SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression.

Jaiswal AS, Narayan S.

Mutat Res. 2002 Mar 20;500(1-2):17-30.


Decitabine, a DNA methyltransferases inhibitor, induces cell cycle arrest at G2/M phase through p53-independent pathway in human cancer cells.

Shin DY, Sung Kang H, Kim GY, Kim WJ, Yoo YH, Choi YH.

Biomed Pharmacother. 2013 May;67(4):305-11. doi: 10.1016/j.biopha.2013.01.004. Epub 2013 Feb 14.


15-lipoxygenase-1 in colorectal cancer: a review.

Bhattacharya S, Mathew G, Jayne DG, Pelengaris S, Khan M.

Tumour Biol. 2009;30(4):185-99. doi: 10.1159/000236864. Epub 2009 Sep 10. Review.


The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.

Lo PK, Lee JS, Sukumar S.

Cell Signal. 2012 Jan;24(1):316-24. doi: 10.1016/j.cellsig.2011.09.017. Epub 2011 Sep 22.

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