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Items: 1 to 20 of 335

1.

C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.

Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14175-80. doi: 10.1073/pnas.0807163105. Epub 2008 Sep 8.

2.

A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors.

Li H, Zemel R, Lopes DH, Monien BH, Bitan G.

ChemMedChem. 2012 Mar 5;7(3):515-22. doi: 10.1002/cmdc.201100584. Epub 2012 Feb 3.

3.

Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease.

Izuo N, Murakami K, Sato M, Iwasaki M, Izumi Y, Shimizu T, Akaike A, Irie K, Kume T.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):1-5. doi: 10.1016/j.bbrc.2013.05.106. Epub 2013 Jun 4.

PMID:
23747423
4.

Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity.

Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G.

Biochemistry. 2010 Feb 16;49(6):1259-67. doi: 10.1021/bi902075h.

5.

Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.

Izuo N, Kume T, Sato M, Murakami K, Irie K, Izumi Y, Akaike A.

ACS Chem Neurosci. 2012 Sep 19;3(9):674-81. Epub 2012 Jun 6.

6.

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species.

Jan A, Adolfsson O, Allaman I, Buccarello AL, Magistretti PJ, Pfeifer A, Muhs A, Lashuel HA.

J Biol Chem. 2011 Mar 11;286(10):8585-96. doi: 10.1074/jbc.M110.172411. Epub 2010 Dec 14.

7.

Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.

Miyamae Y, Kurisu M, Murakami K, Han J, Isoda H, Irie K, Shigemori H.

Bioorg Med Chem. 2012 Oct 1;20(19):5844-9. doi: 10.1016/j.bmc.2012.08.001. Epub 2012 Aug 12.

PMID:
22921742
8.

C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42.

Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G.

J Med Chem. 2011 Dec 22;54(24):8451-60. doi: 10.1021/jm200982p. Epub 2011 Nov 28.

9.

Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3.

Koh SH, Noh MY, Kim SH.

Brain Res. 2008 Jan 10;1188:254-62. Epub 2007 Nov 1.

PMID:
18031715
10.

Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid beta-protein assembly and toxicity.

Ono K, Condron MM, Teplow DB.

J Biol Chem. 2010 Jul 23;285(30):23186-97. doi: 10.1074/jbc.M109.086496. Epub 2010 May 7.

11.

Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization.

De Felice FG, Vieira MN, Saraiva LM, Figueroa-Villar JD, Garcia-Abreu J, Liu R, Chang L, Klein WL, Ferreira ST.

FASEB J. 2004 Sep;18(12):1366-72.

12.

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation.

Feng Y, Wang XP, Yang SG, Wang YJ, Zhang X, Du XT, Sun XX, Zhao M, Huang L, Liu RT.

Neurotoxicology. 2009 Nov;30(6):986-95. doi: 10.1016/j.neuro.2009.08.013. Epub 2009 Sep 8.

PMID:
19744518
13.

Is the viscoelasticity of Alzheimer's Abeta42 peptide oligomers a general property of protein oligomers related to their toxicity?

Saraiva AM, Pereira MC, Brezesinski G.

Langmuir. 2010 Jul 20;26(14):12060-7. doi: 10.1021/la101203h.

PMID:
20515050
14.

Effects of the Arctic (E22-->G) mutation on amyloid beta-protein folding: discrete molecular dynamics study.

Lam AR, Teplow DB, Stanley HE, Urbanc B.

J Am Chem Soc. 2008 Dec 24;130(51):17413-22. doi: 10.1021/ja804984h. Erratum in: J Am Chem Soc. 2011 Mar 2;133(8):2789.

PMID:
19053400
15.

Key residues for the oligomerization of Aβ42 protein in Alzheimer's disease.

Ngo S, Guo Z.

Biochem Biophys Res Commun. 2011 Oct 28;414(3):512-6. doi: 10.1016/j.bbrc.2011.09.097. Epub 2011 Oct 2.

PMID:
21986527
16.

Aβ(39-42) modulates Aβ oligomerization but not fibril formation.

Gessel MM, Wu C, Li H, Bitan G, Shea JE, Bowers MT.

Biochemistry. 2012 Jan 10;51(1):108-17. doi: 10.1021/bi201520b. Epub 2011 Dec 23.

17.

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.

Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B.

EMBO J. 2010 Oct 6;29(19):3408-20. doi: 10.1038/emboj.2010.211. Epub 2010 Sep 3.

18.

Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric β-amyloid 1-42-induced neurotoxicity.

Dai X, Chang P, Zhu Q, Liu W, Sun Y, Zhu S, Jiang Z.

Neurosci Lett. 2013 Oct 25;554:64-9. doi: 10.1016/j.neulet.2013.08.046. Epub 2013 Aug 30.

PMID:
23999027
19.

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

Cascella R, Conti S, Tatini F, Evangelisti E, Scartabelli T, Casamenti F, Wilson MR, Chiti F, Cecchi C.

Biochim Biophys Acta. 2013 Aug;1832(8):1217-26. doi: 10.1016/j.bbadis.2013.04.012. Epub 2013 Apr 16.

20.

Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model.

Krantic S, Isorce N, Mechawar N, Davoli MA, Vignault E, Albuquerque M, Chabot JG, Moyse E, Chauvin JP, Aubert I, McLaurin J, Quirion R.

J Alzheimers Dis. 2012;29(2):293-308. doi: 10.3233/JAD-2011-110830.

PMID:
22232004
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