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Results: 1 to 20 of 123

1.

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.

Harki DA, Satyamurthy N, Stout DB, Phelps ME, Dervan PB.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13039-44. doi: 10.1073/pnas.0806308105. Epub 2008 Aug 27.

PMID:
18753620
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

Raskatov JA, Hargrove AE, So AY, Dervan PB.

J Am Chem Soc. 2012 May 9;134(18):7995-9. doi: 10.1021/ja302588v. Epub 2012 Apr 24.

PMID:
22509786
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Novel diamino imidazole and pyrrole-containing polyamides: Synthesis and DNA binding studies of mono- and diamino-phenyl-ImPy*Im polyamides designed to target 5'-ACGCGT-3'.

Satam V, Babu B, Chavda S, Savagian M, Sjoholm R, Tzou S, Ramos J, Liu Y, Kiakos K, Lin S, David Wilson W, Hartley JA, Lee M.

Bioorg Med Chem. 2012 Jan 15;20(2):693-701. doi: 10.1016/j.bmc.2011.12.010. Epub 2011 Dec 14. Erratum in: Bioorg Med Chem. 2012 Aug 1;20(15):4881. Ramos, Joseph [added].

PMID:
22222156
[PubMed - indexed for MEDLINE]
4.

Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.

Synold TW, Xi B, Wu J, Yen Y, Li BC, Yang F, Phillips JW, Nickols NG, Dervan PB.

Cancer Chemother Pharmacol. 2012 Oct;70(4):617-25. Epub 2012 Aug 21.

PMID:
22907527
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Recognition of the DNA minor groove by pyrrole-imidazole polyamides: comparison of desmethyl- and N-methylpyrrole.

Bremer RE, Szewczyk JW, Baird EE, Dervan PB.

Bioorg Med Chem. 2000 Aug;8(8):1947-55.

PMID:
11003140
[PubMed - indexed for MEDLINE]
6.

Hx, a novel fluorescent, minor groove and sequence specific recognition element: design, synthesis, and DNA binding properties of p-anisylbenzimidazole-imidazole/pyrrole-containing polyamides.

Chavda S, Liu Y, Babu B, Davis R, Sielaff A, Ruprich J, Westrate L, Tronrud C, Ferguson A, Franks A, Tzou S, Adkins C, Rice T, Mackay H, Kluza J, Tahir SA, Lin S, Kiakos K, Bruce CD, Wilson WD, Hartley JA, Lee M.

Biochemistry. 2011 Apr 19;50(15):3127-36. doi: 10.1021/bi102028a. Epub 2011 Mar 25.

PMID:
21388229
[PubMed - indexed for MEDLINE]
7.

Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture.

Jacobs CS, Dervan PB.

J Med Chem. 2009 Dec 10;52(23):7380-8. doi: 10.1021/jm900256f.

PMID:
19572551
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Pharmacokinetics of pyrrole-imidazole polyamides after intravenous administration in rat.

Fukasawa A, Aoyama T, Nagashima T, Fukuda N, Ueno T, Sugiyama H, Nagase H, Matsumoto Y.

Biopharm Drug Dispos. 2009 Mar;30(2):81-9. doi: 10.1002/bdd.648.

PMID:
19226654
[PubMed - indexed for MEDLINE]
9.

Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.

Chenoweth DM, Harki DA, Phillips JW, Dose C, Dervan PB.

J Am Chem Soc. 2009 May 27;131(20):7182-8. doi: 10.1021/ja901309z.

PMID:
19413319
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Characterization and solubilization of pyrrole-imidazole polyamide aggregates.

Hargrove AE, Raskatov JA, Meier JL, Montgomery DC, Dervan PB.

J Med Chem. 2012 Jun 14;55(11):5425-32. doi: 10.1021/jm300380a. Epub 2012 May 24.

PMID:
22607187
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides.

Dickinson LA, Trauger JW, Baird EE, Ghazal P, Dervan PB, Gottesfeld JM.

Biochemistry. 1999 Aug 17;38(33):10801-7.

PMID:
10451376
[PubMed - indexed for MEDLINE]
12.

Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.

Westrate L, Mackay H, Brown T, Nguyen B, Kluza J, Wilson WD, Lee M, Hartley JA.

Biochemistry. 2009 Jun 23;48(24):5679-88. doi: 10.1021/bi900242t.

PMID:
19419200
[PubMed - indexed for MEDLINE]
13.

Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.

Mackay H, Brown T, Uthe PB, Westrate L, Sielaff A, Jones J, Lajiness JP, Kluza J, O'Hare C, Nguyen B, Davis Z, Bruce C, Wilson WD, Hartley JA, Lee M.

Bioorg Med Chem. 2008 Oct 15;16(20):9145-53. doi: 10.1016/j.bmc.2008.09.034. Epub 2008 Sep 13.

PMID:
18819814
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.

Henry JA, Le NM, Nguyen B, Howard CM, Bailey SL, Horick SM, Buchmueller KL, Kotecha M, Hochhauser D, Hartley JA, Wilson WD, Lee M.

Biochemistry. 2004 Sep 28;43(38):12249-57.

PMID:
15379563
[PubMed - indexed for MEDLINE]
15.

Binding of hairpin pyrrole and imidazole polyamides to DNA: relationship between torsion angle and association rate constants.

Han YW, Matsumoto T, Yokota H, Kashiwazaki G, Morinaga H, Hashiya K, Bando T, Harada Y, Sugiyama H.

Nucleic Acids Res. 2012 Dec;40(22):11510-7. doi: 10.1093/nar/gks897. Epub 2012 Oct 4.

PMID:
23042247
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Cysteine cyclic pyrrole-imidazole polyamide for sequence-specific recognition in the DNA minor groove.

Morinaga H, Bando T, Takagaki T, Yamamoto M, Hashiya K, Sugiyama H.

J Am Chem Soc. 2011 Nov 23;133(46):18924-30. doi: 10.1021/ja207440p. Epub 2011 Oct 27.

PMID:
21985474
[PubMed - indexed for MEDLINE]
17.

A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.

Ueno T, Fukuda N, Tsunemi A, Yao EH, Matsuda H, Tahira K, Matsumoto T, Matsumoto K, Matsumoto Y, Nagase H, Sugiyama H, Sawamura T.

J Hypertens. 2009 Mar;27(3):508-16.

PMID:
19330905
[PubMed - indexed for MEDLINE]
18.

Rapid solid-phase synthesis of DNA-binding pyrrole-imidazole polyamides.

Krutzik PO, Chamberlin AR.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2129-32.

PMID:
12127520
[PubMed - indexed for MEDLINE]
19.

Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5'-GCGC-3'.

Han YW, Kashiwazaki G, Morinaga H, Matsumoto T, Hashiya K, Bando T, Harada Y, Sugiyama H.

Bioorg Med Chem. 2013 Sep 1;21(17):5436-41. doi: 10.1016/j.bmc.2013.06.005. Epub 2013 Jun 11.

PMID:
23810670
[PubMed - indexed for MEDLINE]
Free Article
20.

Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides.

Liu B, Kodadek T.

J Med Chem. 2009 Aug 13;52(15):4604-12. doi: 10.1021/jm9002999.

PMID:
19610652
[PubMed - indexed for MEDLINE]
Free PMC Article

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