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Results: 1 to 20 of 83

1.

The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells.

Ruis BL, Fattah KR, Hendrickson EA.

Mol Cell Biol. 2008 Oct;28(20):6182-95. doi: 10.1128/MCB.00355-08. Epub 2008 Aug 18.

PMID:
18710952
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Heterozygous inactivation of human Ku70/Ku86 heterodimer does not affect cell growth, double-strand break repair, or genome integrity.

Uegaki K, Adachi N, So S, Iiizumi S, Koyama H.

DNA Repair (Amst). 2006 Mar 7;5(3):303-11. Epub 2005 Dec 1.

PMID:
16325483
[PubMed - indexed for MEDLINE]
3.

Characterization of two DNA double-stranded break repair-deficient cell lines that express inactive DNA-dependent protein kinase catalytic subunits.

Peterson SR, Stackhouse M, Waltman MJ, Chen F, Sato K, Chen DJ.

J Biol Chem. 1997 Apr 11;272(15):10227-31.

PMID:
9092571
[PubMed - indexed for MEDLINE]
Free Article
4.

Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells.

Zhang Y, Zhou J, Cao X, Zhang Q, Lim CU, Ullrich RL, Bailey SM, Liber HL.

Cancer Lett. 2007 May 18;250(1):63-73. Epub 2006 Nov 13.

PMID:
17095151
[PubMed - indexed for MEDLINE]
5.

Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells.

Bacsi A, Kannan S, Lee MS, Hazra TK, Boldogh I.

Free Radic Biol Med. 2005 Dec 15;39(12):1650-9. Epub 2005 Sep 2.

PMID:
16298690
[PubMed - indexed for MEDLINE]
6.

The lethality of Ku86 (XRCC5) loss-of-function mutations in human cells is independent of p53 (TP53).

Ghosh G, Li G, Myung K, Hendrickson EA.

Radiat Res. 2007 Jan;167(1):66-79.

PMID:
17214517
[PubMed - indexed for MEDLINE]
7.

Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation.

Ayene IS, Ford LP, Koch CJ.

Mol Cancer Ther. 2005 Apr;4(4):529-36.

PMID:
15827325
[PubMed - indexed for MEDLINE]
Free Article
8.

Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas.

Shao CJ, Fu J, Shi HL, Mu YG, Chen ZP.

J Neurooncol. 2008 Aug;89(1):27-35. doi: 10.1007/s11060-008-9592-7. Epub 2008 Apr 16.

PMID:
18415044
[PubMed - indexed for MEDLINE]
9.

The life and death of DNA-PK.

Collis SJ, DeWeese TL, Jeggo PA, Parker AR.

Oncogene. 2005 Feb 3;24(6):949-61. Review.

PMID:
15592499
[PubMed - indexed for MEDLINE]
10.

The role of nonhomologous DNA end joining, conservative homologous recombination, and single-strand annealing in the cell cycle-dependent repair of DNA double-strand breaks induced by H(2)O(2) in mammalian cells.

Frankenberg-Schwager M, Becker M, Garg I, Pralle E, Wolf H, Frankenberg D.

Radiat Res. 2008 Dec;170(6):784-93. doi: 10.1667/RR1375.1.

PMID:
19138034
[PubMed - indexed for MEDLINE]
11.

Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.

Drouet J, Frit P, Delteil C, de Villartay JP, Salles B, Calsou P.

J Biol Chem. 2006 Sep 22;281(38):27784-93. Epub 2006 Jul 19.

PMID:
16857680
[PubMed - indexed for MEDLINE]
Free Article
12.

Impaired telomerase activity in human cells expressing GFP-Ku86 fusion proteins.

Badie C, Yáñez-Muñoz RJ, Muller C, Salles B, Porter AC.

Cytogenet Genome Res. 2008;122(3-4):326-35. doi: 10.1159/000167819. Epub 2009 Jan 30.

PMID:
19188702
[PubMed - indexed for MEDLINE]
13.

KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.

Abe T, Ishiai M, Hosono Y, Yoshimura A, Tada S, Adachi N, Koyama H, Takata M, Takeda S, Enomoto T, Seki M.

Cell Signal. 2008 Nov;20(11):1978-85. doi: 10.1016/j.cellsig.2008.07.006. Epub 2008 Jul 10.

PMID:
18674614
[PubMed - indexed for MEDLINE]
14.

[DNA-dependent protein kinase: a major protein involved in the cellular response to ionizing radiation].

Muller C, Rodrigo G, Calsou P, Salles B.

Bull Cancer. 1999 Dec;86(12):977-83. Review. French.

PMID:
10660692
[PubMed - indexed for MEDLINE]
15.

Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase.

Cheung JC, Salerno B, Hanakahi LA.

Nucleic Acids Res. 2008 Oct;36(17):5713-26. doi: 10.1093/nar/gkn572. Epub 2008 Sep 6.

PMID:
18776215
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.

Soubeyrand S, Pope L, Pakuts B, Haché RJ.

Cancer Res. 2003 Mar 15;63(6):1198-201.

PMID:
12649176
[PubMed - indexed for MEDLINE]
Free Article
17.

Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells.

de Campos-Nebel M, Larripa I, González-Cid M.

Mutat Res. 2008 Nov 10;646(1-2):8-16. doi: 10.1016/j.mrfmmm.2008.08.013. Epub 2008 Sep 4.

PMID:
18812179
[PubMed - indexed for MEDLINE]
18.

Chromosomal end-to-end fusions in immortalized mouse embryonic fibroblasts deficient in the DNA-dependent protein kinase catalytic subunit.

Rebuzzini P, Lisa A, Giulotto E, Mondello C.

Cancer Lett. 2004 Jan 8;203(1):79-86.

PMID:
14670620
[PubMed - indexed for MEDLINE]
19.

Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction.

Oh S, Wang Y, Zimbric J, Hendrickson EA.

Nucleic Acids Res. 2013 Feb 1;41(3):1734-49. doi: 10.1093/nar/gks1326. Epub 2012 Dec 28.

PMID:
23275564
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Ku86 represses lethal telomere deletion events in human somatic cells.

Wang Y, Ghosh G, Hendrickson EA.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12430-5. doi: 10.1073/pnas.0903362106. Epub 2009 Jul 6.

PMID:
19581589
[PubMed - indexed for MEDLINE]
Free PMC Article
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