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Results: 1 to 20 of 74

1.

Phase 2 study of sodium phenylbutyrate in ALS.

Cudkowicz ME, Andres PL, Macdonald SA, Bedlack RS, Choudry R, Brown RH Jr, Zhang H, Schoenfeld DA, Shefner J, Matson S, Matson WR, Ferrante RJ; Northeast ALS and National VA ALS Research Consortiums.

Amyotroph Lateral Scler. 2009 Apr;10(2):99-106. doi: 10.1080/17482960802320487.

PMID:
18688762
[PubMed - indexed for MEDLINE]
2.

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice.

Del Signore SJ, Amante DJ, Kim J, Stack EC, Goodrich S, Cormier K, Smith K, Cudkowicz ME, Ferrante RJ.

Amyotroph Lateral Scler. 2009 Apr;10(2):85-94. doi: 10.1080/17482960802226148.

PMID:
18618304
[PubMed - indexed for MEDLINE]
3.

Sodium phenylbutyrate in Huntington's disease: a dose-finding study.

Hogarth P, Lovrecic L, Krainc D.

Mov Disord. 2007 Oct 15;22(13):1962-4.

PMID:
17702032
[PubMed - indexed for MEDLINE]
4.

Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis.

Piepers S, Veldink JH, de Jong SW, van der Tweel I, van der Pol WL, Uijtendaal EV, Schelhaas HJ, Scheffer H, de Visser M, de Jong JM, Wokke JH, Groeneveld GJ, van den Berg LH.

Ann Neurol. 2009 Aug;66(2):227-34. doi: 10.1002/ana.21620.

PMID:
19743466
[PubMed - indexed for MEDLINE]
5.

Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis.

Cudkowicz ME, Shefner JM, Simpson E, Grasso D, Yu H, Zhang H, Shui A, Schoenfeld D, Brown RH, Wieland S, Barber JR; Northeast ALS Consortium.

Muscle Nerve. 2008 Jul;38(1):837-44. doi: 10.1002/mus.21059.

PMID:
18551622
[PubMed - indexed for MEDLINE]
6.

Multicenter phase II trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2-aminophenyl)-carbamoyl]-benzyl}-carbamate in pretreated metastatic melanoma.

Hauschild A, Trefzer U, Garbe C, Kaehler KC, Ugurel S, Kiecker F, Eigentler T, Krissel H, Schott A, Schadendorf D.

Melanoma Res. 2008 Aug;18(4):274-8. doi: 10.1097/CMR.0b013e328307c248.

PMID:
18626312
[PubMed - indexed for MEDLINE]
7.
8.

Growth inhibition and gene induction in human hepatocellular carcinoma cell exposed to sodium 4-phenylbutanoate.

Wang CT, Meng M, Zhang JC, Jin CJ, Jiang JJ, Ren HS, Jiang JM, Qin CY, Yu DQ.

Chin Med J (Engl). 2008 Sep 5;121(17):1707-11.

PMID:
19024104
[PubMed - indexed for MEDLINE]
Free Article
9.

Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.

Kern RM, Yang Z, Kim PS, Grody WW, Iyer RK, Cederbaum SD.

Mol Genet Metab. 2007 Jan;90(1):37-41. Epub 2006 Aug 28.

PMID:
16935537
[PubMed - indexed for MEDLINE]
10.

Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC.

Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, Daud A, Neuger A, Minton S, Sullivan D.

Clin Cancer Res. 2009 Apr 1;15(7):2488-96. doi: 10.1158/1078-0432.CCR-08-1930. Epub 2009 Mar 24.

PMID:
19318486
[PubMed - indexed for MEDLINE]
Free Article
11.

Histone deacetylase inhibitors: therapeutic agents and research tools for deciphering motor neuron diseases.

Echaniz-Laguna A, Bousiges O, Loeffler JP, Boutillier AL.

Curr Med Chem. 2008;15(13):1263-73. Review.

PMID:
18537606
[PubMed - indexed for MEDLINE]
12.

R+ pramipexole as a mitochondrially focused neuroprotectant: initial early phase studies in ALS.

Wang H, Larriviere KS, Keller KE, Ware KA, Burns TM, Conaway MA, Lacomis D, Pattee GL, Phillips LH 2nd, Solenski NJ, Zivkovic SA, Bennett JP Jr.

Amyotroph Lateral Scler. 2008 Feb;9(1):50-8. doi: 10.1080/17482960701791234.

PMID:
18270879
[PubMed - indexed for MEDLINE]
13.

Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats.

Romieu P, Host L, Gobaille S, Sandner G, Aunis D, Zwiller J.

J Neurosci. 2008 Sep 17;28(38):9342-8. doi: 10.1523/JNEUROSCI.0379-08.2008.

PMID:
18799668
[PubMed - indexed for MEDLINE]
Free Article
14.

Acetylation of non-histone proteins modulates cellular signalling at multiple levels.

Spange S, Wagner T, Heinzel T, Krämer OH.

Int J Biochem Cell Biol. 2009 Jan;41(1):185-98. doi: 10.1016/j.biocel.2008.08.027. Epub 2008 Sep 2. Review.

PMID:
18804549
[PubMed - indexed for MEDLINE]
15.

Identification of phenylbutyrylglutamine, a new metabolite of phenylbutyrate metabolism in humans.

Comte B, Kasumov T, Pierce BA, Puchowicz MA, Scott ME, Dahms W, Kerr D, Nissim I, Brunengraber H.

J Mass Spectrom. 2002 Jun;37(6):581-90.

PMID:
12112740
[PubMed - indexed for MEDLINE]
16.

Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine.

Piscitelli SC, Thibault A, Figg WD, Tompkins A, Headlee D, Lieberman R, Samid D, Myers CE.

J Clin Pharmacol. 1995 Apr;35(4):368-73.

PMID:
7650225
[PubMed - indexed for MEDLINE]
17.

A rationally designed histone deacetylase inhibitor with distinct antitumor activity against ovarian cancer.

Yang YT, Balch C, Kulp SK, Mand MR, Nephew KP, Chen CS.

Neoplasia. 2009 Jun;11(6):552-63, 3 p following 563.

PMID:
19484144
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

[Molecular-targeted therapy for motor neuron disease].

Banno H, Katsuno M, Suzuki K, Iguchi Y, Adachi H, Tanaka F, Sobue G.

Brain Nerve. 2009 Aug;61(8):891-900. Review. Japanese.

PMID:
19697878
[PubMed - indexed for MEDLINE]
19.

Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis.

Martinez JA, Francis GJ, Liu WQ, Pradzinsky N, Fine J, Wilson M, Hanson LR, Frey WH 2nd, Zochodne D, Gordon T, Toth C.

Neuroscience. 2008 Dec 10;157(4):908-25. doi: 10.1016/j.neuroscience.2008.08.073. Epub 2008 Oct 2.

PMID:
18951954
[PubMed - indexed for MEDLINE]
20.

Ultraviolet radiation-induced transcription is associated with gene-specific histone acetylation.

Pollack BP, Sapkota B, Boss JM.

Photochem Photobiol. 2009 May-Jun;85(3):652-62. doi: 10.1111/j.1751-1097.2008.00485.x. Epub 2008 Dec 8.

PMID:
19076306
[PubMed - indexed for MEDLINE]

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