Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 119

1.

Engineering GPCR signaling pathways with RASSLs.

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL.

Nat Methods. 2008 Aug;5(8):673-8. doi: 10.1038/nmeth.1232. Review.

2.

Engineered GPCRs as tools to modulate signal transduction.

Pei Y, Rogan SC, Yan F, Roth BL.

Physiology (Bethesda). 2008 Dec;23:313-21. doi: 10.1152/physiol.00025.2008. Review.

3.

G-protein-coupled designer receptors - new chemical-genetic tools for signal transduction research.

Thiel G, Kaufmann A, Rössler OG.

Biol Chem. 2013 Dec;394(12):1615-22. doi: 10.1515/hsz-2013-0164. Review.

PMID:
23893685
4.

DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.

Urban DJ, Roth BL.

Annu Rev Pharmacol Toxicol. 2015;55:399-417. doi: 10.1146/annurev-pharmtox-010814-124803. Epub 2014 Sep 25. Review.

PMID:
25292433
5.

Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs.

Dong S, Rogan SC, Roth BL.

Nat Protoc. 2010 Mar;5(3):561-73. doi: 10.1038/nprot.2009.239. Epub 2010 Feb 25.

PMID:
20203671
6.

Novel designer receptors to probe GPCR signaling and physiology.

Wess J, Nakajima K, Jain S.

Trends Pharmacol Sci. 2013 Jul;34(7):385-92. doi: 10.1016/j.tips.2013.04.006. Epub 2013 Jun 13. Review.

8.

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.

Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8. Epub 2007 Mar 2.

9.

DREADD: a chemogenetic GPCR signaling platform.

Zhu H, Roth BL.

Int J Neuropsychopharmacol. 2014 Oct 31;18(1). pii: pyu007. doi: 10.1093/ijnp/pyu007.

10.

Generation of designer receptors exclusively activated by designer drugs (DREADDs) using directed molecular evolution.

Pei Y, Dong S, Roth BL.

Curr Protoc Neurosci. 2010 Jan;Chapter 4:Unit 4.33. doi: 10.1002/0471142301.ns0433s50.

PMID:
20066658
11.

Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor.

Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao EC, Conklin BR.

PLoS One. 2007 Dec 19;2(12):e1317. doi: 10.1371/journal.pone.0001317.

12.

Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors.

Nichols CD, Roth BL.

Front Mol Neurosci. 2009 Oct 23;2:16. doi: 10.3389/neuro.02.016.2009. eCollection 2009.

14.

Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine.

Tschammer N, Dörfler M, Hübner H, Gmeiner P.

ACS Chem Neurosci. 2010 Jan 20;1(1):25-35. doi: 10.1021/cn900001b. Epub 2009 Sep 24.

15.

Engineering receptors activated solely by synthetic ligands (RASSLs).

Scearce-Levie K, Coward P, Redfern CH, Conklin BR.

Trends Pharmacol Sci. 2001 Aug;22(8):414-20.

PMID:
11479004
16.

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.

Tang XL, Wang Y, Li DL, Luo J, Liu MY.

Acta Pharmacol Sin. 2012 Mar;33(3):363-71. doi: 10.1038/aps.2011.210. Epub 2012 Feb 27. Review.

17.

GPCR & company: databases and servers for GPCRs and interacting partners.

Kowalsman N, Niv MY.

Adv Exp Med Biol. 2014;796:185-204. doi: 10.1007/978-94-007-7423-0_9. Review.

PMID:
24158806
18.

Functional fusions of T4 lysozyme in the third intracellular loop of a G protein-coupled receptor identified by a random screening approach in yeast.

Mathew E, Ding FX, Naider F, Dumont ME.

Protein Eng Des Sel. 2013 Jan;26(1):59-71. doi: 10.1093/protein/gzs070. Epub 2012 Oct 16.

19.

GPCR oligomers in pharmacology and signaling.

González-Maeso J.

Mol Brain. 2011 May 27;4(1):20. doi: 10.1186/1756-6606-4-20. Review.

20.

Methodological advances: the unsung heroes of the GPCR structural revolution.

Ghosh E, Kumari P, Jaiman D, Shukla AK.

Nat Rev Mol Cell Biol. 2015 Feb;16(2):69-81. doi: 10.1038/nrm3933. Epub 2015 Jan 15. Review.

PMID:
25589408
Items per page

Supplemental Content

Write to the Help Desk