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Results: 1 to 20 of 62

1.

Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.

Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP.

Genes Dev. 2008 Jul 15;22(14):1948-61. doi: 10.1101/gad.1661708.

PMID:
18628400
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

PLoS Biol. 2006 Nov;4(11):e369.

PMID:
17090215
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.

Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM.

Cell Metab. 2006 May;3(5):333-41.

PMID:
16679291
[PubMed - indexed for MEDLINE]
Free Article
4.

A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis.

Lai L, Wang M, Martin OJ, Leone TC, Vega RB, Han X, Kelly DP.

J Biol Chem. 2014 Jan 24;289(4):2250-9. doi: 10.1074/jbc.M113.523654. Epub 2013 Dec 11.

PMID:
24337569
[PubMed - indexed for MEDLINE]
5.

PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis.

Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5223-8. Epub 2007 Mar 12.

PMID:
17360356
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance.

Mitra R, Nogee DP, Zechner JF, Yea K, Gierasch CM, Kovacs A, Medeiros DM, Kelly DP, Duncan JG.

J Mol Cell Cardiol. 2012 Mar;52(3):701-10. doi: 10.1016/j.yjmcc.2011.10.010. Epub 2011 Oct 20.

PMID:
22080103
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.

Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP.

Circ Res. 2014 Feb 14;114(4):626-36. doi: 10.1161/CIRCRESAHA.114.302562. Epub 2013 Dec 23.

PMID:
24366168
[PubMed - indexed for MEDLINE]
8.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16.

PMID:
18487436
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.

Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP.

Circ Res. 2004 Mar 5;94(4):525-33. Epub 2004 Jan 15.

PMID:
14726475
[PubMed - indexed for MEDLINE]
Free Article
10.

PGC-1beta: a co-activator that sets the tone for both basal and stress-stimulated mitochondrial activity.

Lelliott CJ, Vidal-Puig A.

Adv Exp Med Biol. 2009;646:133-9. doi: 10.1007/978-1-4020-9173-5_15. Review.

PMID:
19536672
[PubMed - indexed for MEDLINE]
11.

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM.

Cell Metab. 2005 Apr;1(4):259-71.

PMID:
16054070
[PubMed - indexed for MEDLINE]
Free Article
12.

Transcriptional control of cardiac fuel metabolism and mitochondrial function.

Leone TC, Kelly DP.

Cold Spring Harb Symp Quant Biol. 2011;76:175-82. doi: 10.1101/sqb.2011.76.011965. Epub 2011 Nov 17. Review.

PMID:
22096028
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis.

Chang JS, Fernand V, Zhang Y, Shin J, Jun HJ, Joshi Y, Gettys TW.

J Biol Chem. 2012 Mar 16;287(12):9100-11. doi: 10.1074/jbc.M111.320200. Epub 2012 Jan 26.

PMID:
22282499
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Pyruvate induces mitochondrial biogenesis by a PGC-1 alpha-independent mechanism.

Wilson L, Yang Q, Szustakowski JD, Gullicksen PS, Halse R.

Am J Physiol Cell Physiol. 2007 May;292(5):C1599-605. Epub 2006 Dec 20.

PMID:
17182725
[PubMed - indexed for MEDLINE]
Free Article
15.

PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells.

Huang PI, Chen YC, Chen LH, Juan CC, Ku HH, Wang ST, Chiou SH, Chiou GY, Chi CW, Hsu CC, Lee HC, Chen LK, Kao CL.

J Atheroscler Thromb. 2011;18(11):966-80. Epub 2011 Aug 5.

PMID:
21817823
[PubMed - indexed for MEDLINE]
Free Article
16.

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism.

Pan D, Fujimoto M, Lopes A, Wang YX.

Cell. 2009 Apr 3;137(1):73-86. doi: 10.1016/j.cell.2009.01.051.

PMID:
19345188
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Roles for peroxisome proliferator-activated receptor γ (PPARγ) and PPARγ coactivators 1α and 1β in regulating response of white and brown adipocytes to hypoxia.

Pino E, Wang H, McDonald ME, Qiang L, Farmer SR.

J Biol Chem. 2012 May 25;287(22):18351-8. doi: 10.1074/jbc.M112.350918. Epub 2012 Apr 9.

PMID:
22493496
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.

Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP.

Cell Metab. 2010 Dec 1;12(6):633-42. doi: 10.1016/j.cmet.2010.11.008. Erratum in: Cell Metab. 2011 Jan 5;13(1):114.

PMID:
21109195
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP.

PLoS Biol. 2005 Apr;3(4):e101. Epub 2005 Mar 15.

PMID:
15760270
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

PGC-1α determines light damage susceptibility of the murine retina.

Egger A, Samardzija M, Sothilingam V, Tanimoto N, Lange C, Salatino S, Fang L, Garcia-Garrido M, Beck S, Okoniewski MJ, Neutzner A, Seeliger MW, Grimm C, Handschin C.

PLoS One. 2012;7(2):e31272. doi: 10.1371/journal.pone.0031272. Epub 2012 Feb 13.

PMID:
22348062
[PubMed - indexed for MEDLINE]
Free PMC Article

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