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Results: 1 to 20 of 340

1.

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease.

Ansari A, Arenas M, Greenfield SM, Morris D, Lindsay J, Gilshenan K, Smith M, Lewis C, Marinaki A, Duley J, Sanderson J.

Aliment Pharmacol Ther. 2008 Oct 15;28(8):973-83. doi: 10.1111/j.1365-2036.2008.03788.x.

PMID:
18616518
[PubMed - indexed for MEDLINE]
2.

Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression.

Zelinkova Z, Derijks LJ, Stokkers PC, Vogels EW, van Kampen AH, Curvers WL, Cohn D, van Deventer SJ, Hommes DW.

Clin Gastroenterol Hepatol. 2006 Jan;4(1):44-9.

PMID:
16431304
[PubMed - indexed for MEDLINE]
3.

A 6-thioguanine nucleotide threshold level of 400 pmol/8 x 10(8) erythrocytes predicts azathioprine refractoriness in patients with inflammatory bowel disease and normal TPMT activity.

Roblin X, Peyrin-Biroulet L, Phelip JM, Nancey S, Flourie B.

Am J Gastroenterol. 2008 Dec;103(12):3115-22. doi: 10.1111/j.1572-0241.2008.01743.x. Erratum in: Am J Gastroenterol. 2009 Apr;104(4):1072. Biroulet, Laurent P [corrected to Peyrin-Biroulet, Laurent]. Retraction in: Am J Gastroenterol. 2009 Mar;104(3):801.

PMID:
19086961
[PubMed - indexed for MEDLINE]
4.

Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.

Takatsu N, Matsui T, Murakami Y, Ishihara H, Hisabe T, Nagahama T, Maki S, Beppu T, Takaki Y, Hirai F, Yao K.

J Gastroenterol Hepatol. 2009 Jul;24(7):1258-64. doi: 10.1111/j.1440-1746.2009.05917.x.

PMID:
19682195
[PubMed - indexed for MEDLINE]
5.

Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation.

Breen DP, Marinaki AM, Arenas M, Hayes PC.

Liver Transpl. 2005 Jul;11(7):826-33. Erratum in: Liver Transpl. 2005 Sep;11(9):1150.

PMID:
15973722
[PubMed - indexed for MEDLINE]
Free Article
6.

A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine.

Zabala-Fernández W, Barreiro-de Acosta M, Echarri A, Carpio D, Lorenzo A, Castro J, Martínez-Ares D, Pereira S, Martin-Granizo I, Corton M, Carracedo A, Barros F.

J Gastrointestin Liver Dis. 2011 Sep;20(3):247-53.

PMID:
21961091
[PubMed - indexed for MEDLINE]
Free Article
7.

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

Marinaki AM, Ansari A, Duley JA, Arenas M, Sumi S, Lewis CM, Shobowale-Bakre el-M, Escuredo E, Fairbanks LD, Sanderson JD.

Pharmacogenetics. 2004 Mar;14(3):181-7.

PMID:
15167706
[PubMed - indexed for MEDLINE]
8.

Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study.

von Ahsen N, Armstrong VW, Behrens C, von Tirpitz C, Stallmach A, Herfarth H, Stein J, Bias P, Adler G, Shipkova M, Oellerich M, Kruis W, Reinshagen M, Schütz E.

Clin Chem. 2005 Dec;51(12):2282-8. Epub 2005 Oct 7. Erratum in: Clin Chem. 2006 Aug;52(8):1628. Schütz, Ekkehard [added].

PMID:
16214825
[PubMed - indexed for MEDLINE]
Free Article
9.

Pharmacogenetics of thiopurine therapy in paediatric IBD patients.

De Ridder L, Van Dieren JM, Van Deventer HJ, Stokkers PC, Van der Woude JC, Van Vuuren AJ, Benninga MA, Escher JC, Hommes DW.

Aliment Pharmacol Ther. 2006 Apr 15;23(8):1137-41.

PMID:
16611274
[PubMed - indexed for MEDLINE]
Free Article
10.

Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold.

Gardiner SJ, Gearry RB, Begg EJ, Zhang M, Barclay ML.

Clin Gastroenterol Hepatol. 2008 Jun;6(6):654-60; quiz 604. doi: 10.1016/j.cgh.2008.02.032. Epub 2008 May 7.

PMID:
18467186
[PubMed - indexed for MEDLINE]
11.

TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients.

Kurzawski M, Dziewanowski K, Lener A, Drozdzik M.

Eur J Clin Pharmacol. 2009 May;65(5):533-40. doi: 10.1007/s00228-009-0630-y. Epub 2009 Feb 20.

PMID:
19229528
[PubMed - indexed for MEDLINE]
12.

6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

Dubinsky MC, Yang H, Hassard PV, Seidman EG, Kam LY, Abreu MT, Targan SR, Vasiliauskas EA.

Gastroenterology. 2002 Apr;122(4):904-15.

PMID:
11910342
[PubMed - indexed for MEDLINE]
13.

No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease.

Lindqvist M, Hindorf U, Almer S, Söderkvist P, Ström M, Hjortswang H, Peterson C.

Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1033-7.

PMID:
17065060
[PubMed - indexed for MEDLINE]
14.

Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.

Gearry RB, Barclay ML, Burt MJ, Collett JA, Chapman BA, Roberts RL, Kennedy MA.

Aliment Pharmacol Ther. 2003 Aug 15;18(4):395-400.

PMID:
12940924
[PubMed - indexed for MEDLINE]
Free Article
15.

Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism.

Schwab M, Schäffeler E, Marx C, Fischer C, Lang T, Behrens C, Gregor M, Eichelbaum M, Zanger UM, Kaskas BA.

Pharmacogenetics. 2002 Aug;12(6):429-36.

PMID:
12172211
[PubMed - indexed for MEDLINE]
16.

Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease.

Ansari A, Hassan C, Duley J, Marinaki A, Shobowale-Bakre EM, Seed P, Meenan J, Yim A, Sanderson J.

Aliment Pharmacol Ther. 2002 Oct;16(10):1743-50.

PMID:
12269967
[PubMed - indexed for MEDLINE]
Free Article
17.

Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.

Hindorf U, Lyrenäs E, Nilsson A, Schmiegelow K.

Scand J Gastroenterol. 2004 Nov;39(11):1105-12.

PMID:
15545169
[PubMed - indexed for MEDLINE]
18.

Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients.

Gisbert JP, Niño P, Rodrigo L, Cara C, Guijarro LG.

Am J Gastroenterol. 2006 Dec;101(12):2769-76. Epub 2006 Oct 6.

PMID:
17026564
[PubMed - indexed for MEDLINE]
19.

Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice.

Gearry RB, Barclay ML, Roberts RL, Harraway J, Zhang M, Pike LS, George PM, Florkowski CM.

Intern Med J. 2005 Oct;35(10):580-5.

PMID:
16207256
[PubMed - indexed for MEDLINE]
20.

Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.

Stocco G, Martelossi S, Barabino A, Decorti G, Bartoli F, Montico M, Gotti A, Ventura A.

Inflamm Bowel Dis. 2007 Jan;13(1):57-64.

PMID:
17206640
[PubMed - indexed for MEDLINE]

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