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Results: 1 to 20 of 103

1.

Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2.

Pi J, Diwan BA, Sun Y, Liu J, Qu W, He Y, Styblo M, Waalkes MP.

Free Radic Biol Med. 2008 Sep 1;45(5):651-8. doi: 10.1016/j.freeradbiomed.2008.05.020. Epub 2008 Jun 3.

PMID:
18572023
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis.

Sun Y, Pi J, Wang X, Tokar EJ, Liu J, Waalkes MP.

Toxicology. 2009 Aug 3;262(2):162-70. doi: 10.1016/j.tox.2009.06.003. Epub 2009 Jun 12.

PMID:
19524636
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response.

Sun Y, Kojima C, Chignell C, Mason R, Waalkes MP.

Toxicol Appl Pharmacol. 2011 Sep 15;255(3):242-50. doi: 10.1016/j.taap.2011.07.006. Epub 2011 Jul 21.

PMID:
21820459
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes.

Zhao R, Hou Y, Zhang Q, Woods CG, Xue P, Fu J, Yarborough K, Guan D, Andersen ME, Pi J.

Environ Health Perspect. 2012 Apr;120(4):583-9. doi: 10.1289/ehp.1104580. Epub 2012 Jan 3.

PMID:
22476201
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide.

Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP.

Exp Cell Res. 2003 Nov 1;290(2):234-45.

PMID:
14567983
[PubMed - indexed for MEDLINE]
6.

CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure.

Huang S, Guo S, Guo F, Yang Q, Xiao X, Murata M, Ohnishi S, Kawanishi S, Ma N.

Eur J Histochem. 2013 Jan 14;57(1):e1. doi: 10.4081/ejh.2013.e1.

PMID:
23549458
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.

Sun Y, Tokar EJ, Waalkes MP.

Toxicol Sci. 2012 Jan;125(1):20-9. doi: 10.1093/toxsci/kfr282. Epub 2011 Oct 19.

PMID:
22011395
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance.

He YY, Pi J, Huang JL, Diwan BA, Waalkes MP, Chignell CF.

Oncogene. 2006 Jun 22;25(26):3680-8. Epub 2006 May 8.

PMID:
16682958
[PubMed - indexed for MEDLINE]
9.

A novel role of the NRF2 transcription factor in the regulation of arsenite-mediated keratin 16 gene expression in human keratinocytes.

Endo H, Sugioka Y, Nakagi Y, Saijo Y, Yoshida T.

Environ Health Perspect. 2008 Jul;116(7):873-9. doi: 10.1289/ehp.10696.

PMID:
18629308
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis.

Pi J, He Y, Bortner C, Huang J, Liu J, Zhou T, Qu W, North SL, Kasprzak KS, Diwan BA, Chignell CF, Waalkes MP.

Int J Cancer. 2005 Aug 10;116(1):20-6.

PMID:
15756686
[PubMed - indexed for MEDLINE]
11.

Curcumin protects human keratinocytes against inorganic arsenite-induced acute cytotoxicity through an NRF2-dependent mechanism.

Zhao R, Yang B, Wang L, Xue P, Deng B, Zhang G, Jiang S, Zhang M, Liu M, Pi J, Guan D.

Oxid Med Cell Longev. 2013;2013:412576. doi: 10.1155/2013/412576. Epub 2013 Apr 21.

PMID:
23710286
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.

Jiang R, Li Y, Xu Y, Zhou Y, Pang Y, Shen L, Zhao Y, Zhang J, Zhou J, Wang X, Liu Q.

Arch Toxicol. 2013 Jun;87(6):991-1000. doi: 10.1007/s00204-012-0933-0. Epub 2012 Oct 16.

PMID:
23069812
[PubMed - indexed for MEDLINE]
13.

Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes.

Li Y, Jiang R, Zhao Y, Xu Y, Ling M, Pang Y, Shen L, Zhou Y, Zhang J, Zhou J, Wang X, Liu Q.

Toxicology. 2012 Oct 28;300(3):121-31. doi: 10.1016/j.tox.2012.06.004. Epub 2012 Jun 15.

PMID:
22706169
[PubMed - indexed for MEDLINE]
14.

Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes.

Li B, Li X, Zhu B, Zhang X, Wang Y, Xu Y, Wang H, Hou Y, Zheng Q, Sun G.

Environ Toxicol. 2013 Jul;28(7):401-10. doi: 10.1002/tox.20731. Epub 2011 Aug 1.

PMID:
21809430
[PubMed - indexed for MEDLINE]
15.

Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage.

Yang B, Fu J, Zheng H, Xue P, Yarborough K, Woods CG, Hou Y, Zhang Q, Andersen ME, Pi J.

Toxicol Appl Pharmacol. 2012 Nov 1;264(3):315-23. doi: 10.1016/j.taap.2012.09.012. Epub 2012 Sep 21.

PMID:
23000044
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite.

Li Y, Ling M, Xu Y, Wang S, Li Z, Zhou J, Wang X, Liu Q.

Toxicol Sci. 2010 Jul;116(1):174-82. doi: 10.1093/toxsci/kfq109. Epub 2010 Apr 7.

PMID:
20375080
[PubMed - indexed for MEDLINE]
Free Article
17.

Critical role of cellular glutathione homeostasis for trivalent inorganic arsenite-induced oxidative damage in human bronchial epithelial cells.

Jiang X, Chen C, Liu Y, Zhang P, Zhang Z.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Aug;770:35-45. doi: 10.1016/j.mrgentox.2014.04.016. Epub 2014 May 9.

PMID:
25344162
[PubMed - indexed for MEDLINE]
18.

Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation.

Chen H, Liu J, Zhao CQ, Diwan BA, Merrick BA, Waalkes MP.

Toxicol Appl Pharmacol. 2001 Sep 15;175(3):260-8.

PMID:
11559025
[PubMed - indexed for MEDLINE]
19.

Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expression.

Liu Y, Chan F, Sun H, Yan J, Fan D, Zhao D, An J, Zhou D.

Eur J Pharmacol. 2011 Jan 10;650(1):130-7. doi: 10.1016/j.ejphar.2010.10.009. Epub 2010 Oct 14.

PMID:
20951123
[PubMed - indexed for MEDLINE]
20.

Lucidone protects human skin keratinocytes against free radical-induced oxidative damage and inflammation through the up-regulation of HO-1/Nrf2 antioxidant genes and down-regulation of NF-κB signaling pathway.

Kumar KJ, Yang HL, Tsai YC, Hung PC, Chang SH, Lo HW, Shen PC, Chen SC, Wang HM, Wang SY, Chou CW, Hseu YC.

Food Chem Toxicol. 2013 Sep;59:55-66. doi: 10.1016/j.fct.2013.04.055. Epub 2013 May 24.

PMID:
23712098
[PubMed - indexed for MEDLINE]

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