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Related Citations for PubMed (Select 18566336)


Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease.

Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M.

Am J Respir Cell Mol Biol. 2008 Dec;39(6):673-82. doi: 10.1165/rcmb.2007-0424OC. Epub 2008 Jun 19.


Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema.

Goven D, Boutten A, Leçon-Malas V, Marchal-Sommé J, Amara N, Crestani B, Fournier M, Lesèche G, Soler P, Boczkowski J, Bonay M.

Thorax. 2008 Oct;63(10):916-24. doi: 10.1136/thx.2007.091181. Epub 2008 Jun 17.


Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.

Harvey CJ, Thimmulappa RK, Sethi S, Kong X, Yarmus L, Brown RH, Feller-Kopman D, Wise R, Biswal S.

Sci Transl Med. 2011 Apr 13;3(78):78ra32. doi: 10.1126/scitranslmed.3002042.


Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent.

Vecchio D, Arezzini B, Pecorelli A, Valacchi G, Martorana PA, Gardi C.

Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L704-13. doi: 10.1152/ajplung.00013.2009. Epub 2010 Feb 12.


NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease.

Boutten A, Goven D, Artaud-Macari E, Boczkowski J, Bonay M.

Trends Mol Med. 2011 Jul;17(7):363-71. doi: 10.1016/j.molmed.2011.02.006. Epub 2011 Apr 1. Review.


Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells.

Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T.

Am J Respir Cell Mol Biol. 2008 Oct;39(4):400-11. doi: 10.1165/rcmb.2007-0295OC. Epub 2008 Apr 25.


Aging enhances susceptibility to cigarette smoke-induced inflammation through bronchiolar chemokines.

Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M.

Am J Respir Cell Mol Biol. 2010 Mar;42(3):304-11. doi: 10.1165/rcmb.2009-0025OC. Epub 2009 Jun 2.


Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.

Guan SP, Tee W, Ng DS, Chan TK, Peh HY, Ho WE, Cheng C, Mak JC, Wong WS.

Br J Pharmacol. 2013 Apr;168(7):1707-18. doi: 10.1111/bph.12054.


Expression of concern: Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.

Malhotra D, Thimmulappa R, Vij N, Navas-Acien A, Sussan T, Merali S, Zhang L, Kelsen SG, Myers A, Wise R, Tuder R, Biswal S.

Am J Respir Crit Care Med. 2009 Dec 15;180(12):1196-207. doi: 10.1164/rccm.200903-0324OC. Epub 2009 Oct 1.


N-acetylcysteine protects murine alveolar type II cells from cigarette smoke injury in a nuclear erythroid 2-related factor-2-independent manner.

Messier EM, Day BJ, Bahmed K, Kleeberger SR, Tuder RM, Bowler RP, Chu HW, Mason RJ, Kosmider B.

Am J Respir Cell Mol Biol. 2013 May;48(5):559-67. doi: 10.1165/rcmb.2012-0295OC. Erratum in: Am J Respir Cell Mol Biol. 2013 Jul;49(1):165. Bahmed, Karim [added].


Expression of concern: Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.

Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S.

Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604. doi: 10.1164/rccm.200803-380OC. Epub 2008 Jun 12. Erratum in: Am J Respir Crit Care Med. 2009 Apr 1;179(7):624.


Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke.

Messier EM, Bahmed K, Tuder RM, Chu HW, Bowler RP, Kosmider B.

Cell Death Dis. 2013 Apr 4;4:e573. doi: 10.1038/cddis.2013.96.


Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.

Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K, Barnes PJ.

Biochem Biophys Res Commun. 2011 Mar 11;406(2):292-8. doi: 10.1016/j.bbrc.2011.02.035. Epub 2011 Feb 12.


Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S.

Am J Respir Cell Mol Biol. 2010 May;42(5):524-36. doi: 10.1165/rcmb.2009-0054OC. Epub 2009 Jun 11.


[The effect of transcription factor KLF2 in expression of gamma-GCS depend on regulation by Nrf2 in lung of rats with chronic obstructive pulmonary disease].

Liu XY, Dai AG, Hu RC, Zhu LM, Tan SX.

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Mar;28(2):173-8. Chinese.


Markers of anti-oxidant response in tobacco smoke exposed subjects: a data-mining review.

Comandini A, Marzano V, Curradi G, Federici G, Urbani A, Saltini C.

Pulm Pharmacol Ther. 2010 Dec;23(6):482-92. doi: 10.1016/j.pupt.2010.05.006. Epub 2010 Jun 1. Review.


Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice.

Bracke KR, Dentener MA, Papakonstantinou E, Vernooy JH, Demoor T, Pauwels NS, Cleutjens J, van Suylen RJ, Joos GF, Brusselle GG, Wouters EF.

Am J Respir Cell Mol Biol. 2010 Jun;42(6):753-61. doi: 10.1165/rcmb.2008-0424OC. Epub 2009 Aug 12.


Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients.

Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Hata J, Takahashi H, Nishimura M.

Inhal Toxicol. 2008 Feb;20(3):349-59. doi: 10.1080/08958370701866412 .


The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes.

Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schüller J, Xu H, Taguchi K, Yamamoto M, Müller T.

Toxicol Sci. 2010 May;115(1):238-52. doi: 10.1093/toxsci/kfq039. Epub 2010 Feb 4.


Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease.

Bracke KR, Verhamme FM, Seys LJ, Bantsimba-Malanda C, Cunoosamy DM, Herbst R, Hammad H, Lambrecht BN, Joos GF, Brusselle GG.

Am J Respir Crit Care Med. 2013 Aug 1;188(3):343-55. doi: 10.1164/rccm.201211-2055OC.

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