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Results: 1 to 20 of 127

1.

The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.

Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID.

Mol Pharmacol. 2008 Sep;74(3):854-62. doi: 10.1124/mol.108.045443. Epub 2008 Jun 4.

PMID:
18524888
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.

Wang Y, Zhao R, Goldman ID.

Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6256-64.

PMID:
15448015
[PubMed - indexed for MEDLINE]
Free Article
3.
4.

Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.

Mahadeo K, Diop-Bove N, Shin D, Unal ES, Teo J, Zhao R, Chang MH, Fulterer A, Romero MF, Goldman ID.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1153-61. doi: 10.1152/ajpcell.00113.2010. Epub 2010 Aug 4.

PMID:
20686069
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.

Desmoulin SK, Wang Y, Wu J, Stout M, Hou Z, Fulterer A, Chang MH, Romero MF, Cherian C, Gangjee A, Matherly LH.

Mol Pharmacol. 2010 Oct;78(4):577-87. doi: 10.1124/mol.110.065896. Epub 2010 Jul 2.

PMID:
20601456
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.

Desmoulin SK, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH.

Mol Pharmacol. 2012 Oct;82(4):591-600. Epub 2012 Jun 26.

PMID:
22740639
[PubMed - indexed for MEDLINE]
Free PMC Article
7.
8.

The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed.

Zhao R, Goldman ID.

Cancer Metastasis Rev. 2007 Mar;26(1):129-39. Review.

PMID:
17340171
[PubMed - indexed for MEDLINE]
9.

Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1).

Visentin M, Chang MH, Romero MF, Zhao R, Goldman ID.

Mol Pharmacol. 2012 Feb;81(2):134-42. doi: 10.1124/mol.111.074823. Epub 2011 Oct 21.

PMID:
22021325
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
11.

The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.

Chattopadhyay S, Zhao R, Krupenko SA, Krupenko N, Goldman ID.

Mol Cancer Ther. 2006 Feb;5(2):438-49.

PMID:
16505119
[PubMed - indexed for MEDLINE]
Free Article
14.

Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier.

Zhao R, Chattopadhyay S, Hanscom M, Goldman ID.

Clin Cancer Res. 2004 Dec 15;10(24):8735-42.

PMID:
15623659
[PubMed - indexed for MEDLINE]
Free Article
15.

A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.

Shin DS, Zhao R, Yap EH, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2012 May 1;302(9):C1405-12. doi: 10.1152/ajpcell.00435.2011. Epub 2012 Feb 15.

PMID:
22345511
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.

Zhao R, Zhang S, Hanscom M, Chattopadhyay S, Goldman ID.

Clin Cancer Res. 2005 Feb 1;11(3):1294-301.

PMID:
15709201
[PubMed - indexed for MEDLINE]
Free Article
17.
18.

The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.

Unal ES, Zhao R, Chang MH, Fiser A, Romero MF, Goldman ID.

J Biol Chem. 2009 Jun 26;284(26):17846-57. doi: 10.1074/jbc.M109.008060. Epub 2009 Apr 23.

PMID:
19389703
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.

Unal ES, Zhao R, Goldman ID.

Am J Physiol Cell Physiol. 2009 Jul;297(1):C66-74. doi: 10.1152/ajpcell.00096.2009. Epub 2009 Apr 29.

PMID:
19403800
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.

Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH, Goldman ID.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1669-78. Epub 2007 Sep 26.

PMID:
17898134
[PubMed - indexed for MEDLINE]
Free Article

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