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A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.

Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA.

PLoS One. 2008 Jun 4;3(6):e2264. doi: 10.1371/journal.pone.0002264. Erratum in: PLoS ONE. 2008;3(6). doi: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/8333176c-b08c-4dfb-a829-6331c0fc6064. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/7d56e94e-3582-413d-b987-fccd0da79081.


Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart.

Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R.

Exp Gerontol. 2008 Sep;43(9):859-66. doi: 10.1016/j.exger.2008.06.013. Epub 2008 Jul 9.


Calorie restriction and resveratrol supplementation prevent age-related DNA and RNA oxidative damage in a non-human primate.

Marchal J, Dal-Pan A, Epelbaum J, Blanc S, Mueller S, Wittig Kieffer M, Metzger F, Aujard F; RESTRIKAL Consortium.

Exp Gerontol. 2013 Sep;48(9):992-1000. doi: 10.1016/j.exger.2013.07.002. Epub 2013 Jul 13.


Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R.

Cell Metab. 2008 Aug;8(2):157-68. doi: 10.1016/j.cmet.2008.06.011. Epub 2008 Jul 3.


Gene expression profiling studies of aging in cardiac and skeletal muscles.

Park SK, Prolla TA.

Cardiovasc Res. 2005 May 1;66(2):205-12. Review.


The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster.

Wang C, Wheeler CT, Alberico T, Sun X, Seeberger J, Laslo M, Spangler E, Kern B, de Cabo R, Zou S.

Age (Dordr). 2013 Feb;35(1):69-81. doi: 10.1007/s11357-011-9332-3. Epub 2011 Nov 16.


Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus.

Marchal J, Blanc S, Epelbaum J, Aujard F, Pifferi F.

PLoS One. 2012;7(3):e34289. doi: 10.1371/journal.pone.0034289. Epub 2012 Mar 30.


The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice.

Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA.

Free Radic Biol Med. 2004 Apr 15;36(8):1043-57.


Lessons learned from gene expression profile studies of aging and caloric restriction.

Park SK, Prolla TA.

Ageing Res Rev. 2005 Jan;4(1):55-65. Epub 2004 Dec 8. Review.


Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice.

Weindruch R, Kayo T, Lee CK, Prolla TA.

J Nutr. 2001 Mar;131(3):918S-923S. Review.


Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index.

Kane AE, Hilmer SN, Boyer D, Gavin K, Nines D, Howlett SE, de Cabo R, Mitchell SJ.

J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):333-9. doi: 10.1093/gerona/glu315. Epub 2015 Feb 22.


Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity.

Dutta D, Xu J, Dirain ML, Leeuwenburgh C.

Free Radic Biol Med. 2014 Sep;74:252-62. doi: 10.1016/j.freeradbiomed.2014.06.011. Epub 2014 Jun 26. Erratum in: Free Radic Biol Med. 2015 Apr;81:183. Dutta, Debariya [corrected to Dutta, Debapriya].


Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys.

Kayo T, Allison DB, Weindruch R, Prolla TA.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5093-8. Epub 2001 Apr 17.


Resveratrol protects against age-associated infertility in mice.

Liu M, Yin Y, Ye X, Zeng M, Zhao Q, Keefe DL, Liu L.

Hum Reprod. 2013 Mar;28(3):707-17. doi: 10.1093/humrep/des437. Epub 2013 Jan 4.


Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice.

Jackson JR, Ryan MJ, Alway SE.

J Gerontol A Biol Sci Med Sci. 2011 Jul;66(7):751-64. doi: 10.1093/gerona/glr047. Epub 2011 Mar 31.


Resveratrol vs. calorie restriction: data from rodents to humans.

Lam YY, Peterson CM, Ravussin E.

Exp Gerontol. 2013 Oct;48(10):1018-24. doi: 10.1016/j.exger.2013.04.005. Epub 2013 Apr 25. Review.


Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan.

Cai W, He JC, Zhu L, Chen X, Zheng F, Striker GE, Vlassara H.

Am J Pathol. 2008 Aug;173(2):327-36. doi: 10.2353/ajpath.2008.080152. Epub 2008 Jul 3.


Gene expression profile of aging and its retardation by caloric restriction.

Lee CK, Klopp RG, Weindruch R, Prolla TA.

Science. 1999 Aug 27;285(5432):1390-3.


Lifespan extension by caloric restriction: an aspect of energy metabolism.

Yamaza H, Chiba T, Higami Y, Shimokawa I.

Microsc Res Tech. 2002 Nov 15;59(4):325-30. Review.


Resveratrol prevents suppression of regulatory T-cell production, oxidative stress, and inflammation of mice prone or resistant to high-fat diet-induced obesity.

Wang B, Sun J, Li X, Zhou Q, Bai J, Shi Y, Le G.

Nutr Res. 2013 Nov;33(11):971-81. doi: 10.1016/j.nutres.2013.07.016. Epub 2013 Aug 27.

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