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Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice.

Raina K, Rajamanickam S, Singh RP, Agarwal R.

Clin Cancer Res. 2008 May 15;14(10):3177-84. doi: 10.1158/1078-0432.CCR-07-5275.


Inositol hexaphosphate inhibits tumor growth, vascularity, and metabolism in TRAMP mice: a multiparametric magnetic resonance study.

Raina K, Ravichandran K, Rajamanickam S, Huber KM, Serkova NJ, Agarwal R.

Cancer Prev Res (Phila). 2013 Jan;6(1):40-50. doi: 10.1158/1940-6207.CAPR-12-0387. Epub 2012 Dec 4.


Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice.

Raina K, Singh RP, Agarwal R, Agarwal C.

Cancer Res. 2007 Jun 15;67(12):5976-82.


Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice.

Raina K, Rajamanickam S, Deep G, Singh M, Agarwal R, Agarwal C.

Mol Cancer Ther. 2008 May;7(5):1258-67. doi: 10.1158/1535-7163.MCT-07-2220. Epub 2008 Apr 29.


Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice.

Gupta S, Ahmad N, Marengo SR, MacLennan GT, Greenberg NM, Mukhtar H.

Cancer Res. 2000 Sep 15;60(18):5125-33.


Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.

Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glodé LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R.

Cancer Res. 2007 Nov 15;67(22):11083-91.


Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model.

Raina K, Rajamanickam S, Singh RP, Deep G, Chittezhath M, Agarwal R.

Cancer Res. 2008 Aug 15;68(16):6822-30. doi: 10.1158/0008-5472.CAN-08-1332.


Prostate cancer and inositol hexaphosphate: efficacy and mechanisms.

Singh RP, Agarwal R.

Anticancer Res. 2005 Jul-Aug;25(4):2891-903. Review.


Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model.

Gupta S, Adhami VM, Subbarayan M, MacLennan GT, Lewin JS, Hafeli UO, Fu P, Mukhtar H.

Cancer Res. 2004 May 1;64(9):3334-43.


Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target.

Gu M, Roy S, Raina K, Agarwal C, Agarwal R.

Cancer Res. 2009 Dec 15;69(24):9465-72. doi: 10.1158/0008-5472.CAN-09-2805. Epub .


Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways.

Shanmugam MK, Ong TH, Kumar AP, Lun CK, Ho PC, Wong PT, Hui KM, Sethi G.

PLoS One. 2012;7(3):e32476. doi: 10.1371/journal.pone.0032476. Epub 2012 Mar 12.


p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer.

Roy S, Gu M, Ramasamy K, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R.

Cancer Res. 2009 Feb 1;69(3):1166-73. doi: 10.1158/0008-5472.CAN-08-3115. Epub 2009 Jan 27.


Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease.

Adhami VM, Siddiqui IA, Sarfaraz S, Khwaja SI, Hafeez BB, Ahmad N, Mukhtar H.

Clin Cancer Res. 2009 Mar 15;15(6):1947-53. doi: 10.1158/1078-0432.CCR-08-2332. Epub 2009 Mar 10.


Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice.

Singh SV, Powolny AA, Stan SD, Xiao D, Arlotti JA, Warin R, Hahm ER, Marynowski SW, Bommareddy A, Potter DM, Dhir R.

Cancer Res. 2008 Nov 15;68(22):9503-11. doi: 10.1158/0008-5472.CAN-08-1677.

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