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Results: 1 to 20 of 449

1.

Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities.

Bydal P, Luu-The V, Labrie F, Poirier D.

Eur J Med Chem. 2009 Feb;44(2):632-44. doi: 10.1016/j.ejmech.2008.03.020. Epub 2008 Apr 8.

PMID:
18472187
[PubMed - indexed for MEDLINE]
2.

Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.

Poirier D, Bydal P, Tremblay MR, Sam KM, Luu-The V.

Mol Cell Endocrinol. 2001 Jan 22;171(1-2):119-28.

PMID:
11165020
[PubMed - indexed for MEDLINE]
4.
6.

Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities.

Tremblay MR, Luu-The V, Leblanc G, Noël P, Breton E, Labrie F, Poirier D.

Bioorg Med Chem. 1999 Jun;7(6):1013-23.

PMID:
10428369
[PubMed - indexed for MEDLINE]
8.

Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone.

Laplante Y, Cadot C, Fournier MA, Poirier D.

Bioorg Med Chem. 2008 Feb 15;16(4):1849-60. Epub 2007 Nov 5.

PMID:
18035543
[PubMed - indexed for MEDLINE]
9.
10.

Contraceptive progestins. Various 11-substituents combined with four 17-substituents: 17alpha-ethynyl, five- and six-membered spiromethylene ethers or six-membered spiromethylene lactones.

Schoonen WG, Deckers G, de Gooijer ME, de Ries R, Mathijssen-Mommers G, Hamersma H, Kloosterboer HJ.

J Steroid Biochem Mol Biol. 2000 Oct;74(3):109-23.

PMID:
11086230
[PubMed - indexed for MEDLINE]
11.

Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).

Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N.

Mol Cell Endocrinol. 2001 Jan 22;171(1-2):137-49.

PMID:
11165022
[PubMed - indexed for MEDLINE]
12.

Parallel solid-phase synthesis of 3beta-peptido-3alpha-hydroxy-5alpha-androstan-17-one derivatives for inhibition of type 3 17beta-hydroxysteroid dehydrogenase.

Maltais R, Luu-The V, Poirier D.

Bioorg Med Chem. 2001 Dec;9(12):3101-11.

PMID:
11711285
[PubMed - indexed for MEDLINE]
13.

Synthesis and preliminary evaluation of a modified estradiol-core bearing a fused γ-lactone as non-estrogenic inhibitor of 17β-hydroxysteroid dehydrogenase type 1.

Ouellet E, Ayan D, Poirier D.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5510-3. doi: 10.1016/j.bmcl.2011.06.110. Epub 2011 Jun 30.

PMID:
21782424
[PubMed - indexed for MEDLINE]
14.

Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.

Day JM, Tutill HJ, Foster PA, Bailey HV, Heaton WB, Sharland CM, Vicker N, Potter BV, Purohit A, Reed MJ.

Mol Cell Endocrinol. 2009 Mar 25;301(1-2):251-8. doi: 10.1016/j.mce.2008.08.014. Epub 2008 Aug 22.

PMID:
18786604
[PubMed - indexed for MEDLINE]
15.
16.

Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3.

Maltais R, Fournier MA, Poirier D.

Bioorg Med Chem. 2011 Aug 1;19(15):4652-68. doi: 10.1016/j.bmc.2011.06.003. Epub 2011 Jun 13.

PMID:
21741247
[PubMed - indexed for MEDLINE]
17.

Steroidal spiro-gamma-lactones that inhibit 17 beta-hydroxysteroid dehydrogenase activity in human placental microsomes.

Sam KM, Auger S, Luu-The V, Poirier D.

J Med Chem. 1995 Oct 27;38(22):4518-28.

PMID:
7473580
[PubMed - indexed for MEDLINE]
19.

Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

Brozic P, Lanisnik Risner T, Gobec S.

Curr Med Chem. 2008;15(2):137-50. Review.

PMID:
18220769
[PubMed - indexed for MEDLINE]
20.

Synthesis of 5α-androstane-17-spiro-δ-lactones with a 3-keto, 3-hydroxy, 3-spirocarbamate or 3-spiromorpholinone as inhibitors of 17β-hydroxysteroid dehydrogenases.

Djigoué GB, Ngatcha BT, Roy J, Poirier D.

Molecules. 2013 Jan 11;18(1):914-33. doi: 10.3390/molecules18010914.

PMID:
23344201
[PubMed - indexed for MEDLINE]
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