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hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.

Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J.

Mol Cell Biol. 2013 Dec;33(24):4960-70. doi: 10.1128/MCB.00874-13. Epub 2013 Oct 14.


Negative regulation of the deacetylase SIRT1 by DBC1.

Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W.

Nature. 2008 Jan 31;451(7178):587-90. doi: 10.1038/nature06515.


DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.

Zannini L, Buscemi G, Kim JE, Fontanella E, Delia D.

J Mol Cell Biol. 2012 Oct;4(5):294-303. doi: 10.1093/jmcb/mjs035. Epub 2012 Jun 26.


Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.

Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA.

Cell Cycle. 2013 Jul 15;12(14):2233-40. doi: 10.4161/cc.25268.


DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor.

Brunquell J, Yuan J, Erwin A, Westerheide SD, Xue B.

Biomed Res Int. 2014;2014:418458. doi: 10.1155/2014/418458. Epub 2014 Dec 11.


DBC1 is a negative regulator of SIRT1.

Kim JE, Chen J, Lou Z.

Nature. 2008 Jan 31;451(7178):583-6. doi: 10.1038/nature06500.


The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.

Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, Sternglanz R.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5807-11.


Structure and biochemical functions of SIRT6.

Pan PW, Feldman JL, Devries MK, Dong A, Edwards AM, Denu JM.

J Biol Chem. 2011 Apr 22;286(16):14575-87. doi: 10.1074/jbc.M111.218990. Epub 2011 Mar 1.


Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy.

Yu EJ, Kim SH, Heo K, Ou CY, Stallcup MR, Kim JH.

Nucleic Acids Res. 2011 Sep 1;39(16):6932-43. doi: 10.1093/nar/gkr347. Epub 2011 May 19.


Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.

Nin V, Escande C, Chini CC, Giri S, Camacho-Pereira J, Matalonga J, Lou Z, Chini EN.

J Biol Chem. 2012 Jul 6;287(28):23489-501. doi: 10.1074/jbc.M112.365874. Epub 2012 May 2.


MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.

Pangon L, Mladenova D, Watkins L, Van Kralingen C, Currey N, Al-Sohaily S, Lecine P, Borg JP, Kohonen-Corish MR.

Int J Cancer. 2015 Jan 1;136(1):55-64. doi: 10.1002/ijc.28967. Epub 2014 May 27.


Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.

Du J, Jiang H, Lin H.

Biochemistry. 2009 Apr 7;48(13):2878-90. doi: 10.1021/bi802093g.


SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.

Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG.

J Biol Chem. 2005 Mar 18;280(11):10264-76. Epub 2005 Jan 4.


The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.

Menssen A, Hydbring P, Kapelle K, Vervoorts J, Diebold J, Lüscher B, Larsson LG, Hermeking H.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):E187-96. doi: 10.1073/pnas.1105304109. Epub 2011 Dec 21.


Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases.

Borra MT, O'Neill FJ, Jackson MD, Marshall B, Verdin E, Foltz KR, Denu JM.

J Biol Chem. 2002 Apr 12;277(15):12632-41. Epub 2002 Jan 25.


Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.

Nin V, Chini CC, Escande C, Capellini V, Chini EN.

J Biol Chem. 2014 Feb 28;289(9):5518-27. doi: 10.1074/jbc.M113.512913. Epub 2014 Jan 10.


Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.

Park JH, Lee SW, Yang SW, Yoo HM, Park JM, Seong MW, Ka SH, Oh KH, Jeon YJ, Chung CH.

Nat Commun. 2014 Nov 18;5:5483. doi: 10.1038/ncomms6483.


Structure-based mechanism of ADP-ribosylation by sirtuins.

Hawse WF, Wolberger C.

J Biol Chem. 2009 Nov 27;284(48):33654-61. doi: 10.1074/jbc.M109.024521. Epub 2009 Sep 30.

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