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Results: 1 to 20 of 82

1.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine.

Wentland MP, Sun X, Cohen DJ, Bidlack JM.

Bioorg Med Chem. 2008 May 15;16(10):5653-64. doi: 10.1016/j.bmc.2008.03.066. Epub 2008 Mar 30.

PMID:
18417347
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine.

Wentland MP, Lu Q, Ganorkar R, Zhang SZ, Jo S, Cohen DJ, Bidlack JM.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):365-8. doi: 10.1016/j.bmcl.2008.11.076. Epub 2008 Nov 24.

PMID:
19091564
[PubMed - indexed for MEDLINE]
3.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC.

VanAlstine MA, Wentland MP, Cohen DJ, Bidlack JM.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6516-20. Epub 2007 Sep 29.

PMID:
17935988
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine.

Wentland MP, VanAlstine M, Kucejko R, Lou R, Cohen DJ, Parkhill AL, Bidlack JM.

J Med Chem. 2006 Sep 7;49(18):5635-9.

PMID:
16942039
[PubMed - indexed for MEDLINE]
5.

Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.

Wentland MP, Ye Y, Cioffi CL, Lou R, Zhou Q, Xu G, Duan W, Dehnhardt CM, Sun X, Cohen DJ, Bidlack JM.

J Med Chem. 2003 Feb 27;46(5):838-49.

PMID:
12593663
[PubMed - indexed for MEDLINE]
6.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC.

Wentland MP, Jo S, Gargano JM, VanAlstine MA, Cohen DJ, Bidlack JM.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7340-4. doi: 10.1016/j.bmcl.2012.10.081. Epub 2012 Oct 27.

PMID:
23142613
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

8-Aminocyclazocine analogues: synthesis and structure-activity relationships.

Wentland MP, Xu G, Cioffi CL, Ye Y, Duan W, Cohen DJ, Colasurdo AM, Bidlack JM.

Bioorg Med Chem Lett. 2000 Jan 17;10(2):183-7.

PMID:
10673107
[PubMed - indexed for MEDLINE]
8.

8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines.

Wentland MP, Lou R, Ye Y, Cohen DJ, Richardson GP, Bidlack JM.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):623-6.

PMID:
11266156
[PubMed - indexed for MEDLINE]
9.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine.

Wentland MP, Sun X, Bu Y, Lou R, Cohen DJ, Bidlack JM.

Bioorg Med Chem Lett. 2005 May 16;15(10):2547-51.

PMID:
15863314
[PubMed - indexed for MEDLINE]
10.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues.

Wentland MP, Sun X, Ye Y, Lou R, Bidlack JM.

Bioorg Med Chem Lett. 2003 Jun 2;13(11):1911-4.

PMID:
12749896
[PubMed - indexed for MEDLINE]
11.

8-Carboxamidocyclazocine: a long-acting, novel benzomorphan.

Bidlack JM, Cohen DJ, McLaughlin JP, Lou R, Ye Y, Wentland MP.

J Pharmacol Exp Ther. 2002 Jul;302(1):374-80.

PMID:
12065740
[PubMed - indexed for MEDLINE]
Free Article
12.

Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1.

Takeuchi K, Holloway WG, McKinzie JH, Suter TM, Statnick MA, Surface PL, Emmerson PJ, Thomas EM, Siegel MG, Matt JE, Wolfe CN, Mitch CH.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. Epub 2007 Aug 11.

PMID:
17720493
[PubMed - indexed for MEDLINE]
13.

Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.

Goto Y, Arai-Otsuki S, Tachibana Y, Ichikawa D, Ozaki S, Takahashi H, Iwasawa Y, Okamoto O, Okuda S, Ohta H, Sagara T.

J Med Chem. 2006 Feb 9;49(3):847-9.

PMID:
16451050
[PubMed - indexed for MEDLINE]
14.

Synthesis, stereochemistry, and analgesic activity of 4-mono- and 4,4-disubstituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines.

Ogundaini AO, Parfitt RT.

J Med Chem. 1985 Feb;28(2):177-81.

PMID:
3968681
[PubMed - indexed for MEDLINE]
15.

Preparation and analgesic activity of (-)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines.

Cittern PA, Kapoor VK, Parfitt RT.

J Med Chem. 1986 Oct;29(10):1929-33.

PMID:
2876100
[PubMed - indexed for MEDLINE]
16.

[6,7]-heterocycle-fused 14-hydroxymorphinan derivatives: design, synthesis, and opioid receptor activity.

Li F, Yin C, Chen J, Liu J, Xie X, Zhang A.

ChemMedChem. 2009 Dec;4(12):2103-10. doi: 10.1002/cmdc.200900308.

PMID:
19847845
[PubMed - indexed for MEDLINE]
17.

Synthesis and pharmacological properties of 1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocines.

Mazzocchi PH, Stahly BC.

J Med Chem. 1981 Apr;24(4):457-62.

PMID:
7265131
[PubMed - indexed for MEDLINE]
18.

Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.

Wentland MP, Lou R, Lu Q, Bu Y, VanAlstine MA, Cohen DJ, Bidlack JM.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. doi: 10.1016/j.bmcl.2008.10.134. Epub 2008 Nov 7.

PMID:
19027293
[PubMed - indexed for MEDLINE]
19.

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.

Balboni G, Salvadori S, Marczak ED, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Si YG, Neumeyer JL.

Eur J Med Chem. 2011 Feb;46(2):799-803. doi: 10.1016/j.ejmech.2010.12.001. Epub 2010 Dec 8.

PMID:
21216504
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors.

VanAlstine MA, Wentland MP, Alvarez J, Cao Q, Cohen DJ, Knapp BI, Bidlack JM.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2128-33. doi: 10.1016/j.bmcl.2013.01.117. Epub 2013 Feb 8.

PMID:
23434225
[PubMed - indexed for MEDLINE]
Free PMC Article

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