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Results: 1 to 20 of 110

1.

Gamma-secretase inhibition and modulation for Alzheimer's disease.

Wolfe MS.

Curr Alzheimer Res. 2008 Apr;5(2):158-64. Review.

PMID:
18393800
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Inhibition and modulation of gamma-secretase for Alzheimer's disease.

Wolfe MS.

Neurotherapeutics. 2008 Jul;5(3):391-8. doi: 10.1016/j.nurt.2008.05.010. Review.

PMID:
18625450
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

gamma-Secretase modulators.

Wolfe MS.

Curr Alzheimer Res. 2007 Dec;4(5):571-3. Review.

PMID:
18220525
[PubMed - indexed for MEDLINE]
4.

gamma-Secretase as a therapeutic target in Alzheimer's disease.

Guardia-Laguarta C, Pera M, Lleó A.

Curr Drug Targets. 2010 Apr;11(4):506-17. Review.

PMID:
20015011
[PubMed - indexed for MEDLINE]
5.

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.

Evin G, Sernee MF, Masters CL.

CNS Drugs. 2006;20(5):351-72. Review.

PMID:
16696577
[PubMed - indexed for MEDLINE]
6.

[Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity].

Tomita T.

Rinsho Shinkeigaku. 2009 Nov;49(11):845-7. Review. Japanese.

PMID:
20030227
[PubMed - indexed for MEDLINE]
7.

Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation.

Panza F, Frisardi V, Solfrizzi V, Imbimbo BP, Logroscino G, Santamato A, Greco A, Seripa D, Pilotto A.

Curr Med Chem. 2011;18(35):5430-47. Review.

PMID:
22087836
[PubMed - indexed for MEDLINE]
8.

γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes.

Imbimbo BP, Giardina GA.

Curr Top Med Chem. 2011;11(12):1555-70. Review.

PMID:
21510832
[PubMed - indexed for MEDLINE]
9.

Therapeutic potential of gamma-secretase inhibitors and modulators.

Imbimbo BP.

Curr Top Med Chem. 2008;8(1):54-61. Review.

PMID:
18220933
[PubMed - indexed for MEDLINE]
10.

γ-Secretase as a target for Alzheimer's disease.

Wolfe MS.

Adv Pharmacol. 2012;64:127-53. doi: 10.1016/B978-0-12-394816-8.00004-0. Review.

PMID:
22840746
[PubMed - indexed for MEDLINE]
11.

Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.

D'Onofrio G, Panza F, Frisardi V, Solfrizzi V, Imbimbo BP, Paroni G, Cascavilla L, Seripa D, Pilotto A.

Expert Opin Drug Discov. 2012 Jan;7(1):19-37. doi: 10.1517/17460441.2012.645534. Epub 2011 Dec 14. Review.

PMID:
22468891
[PubMed - indexed for MEDLINE]
12.

Development and mechanism of γ-secretase modulators for Alzheimer's disease.

Crump CJ, Johnson DS, Li YM.

Biochemistry. 2013 May 14;52(19):3197-216. doi: 10.1021/bi400377p. Epub 2013 May 2. Review.

PMID:
23614767
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

γ-secretase substrates and their implications for drug development in Alzheimer's disease.

Lleó A, Saura CA.

Curr Top Med Chem. 2011;11(12):1513-27. Review.

PMID:
21510835
[PubMed - indexed for MEDLINE]
14.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

PMID:
19671883
[PubMed - indexed for MEDLINE]
Free Article
15.

Selective amyloid-beta lowering agents.

Wolfe MS.

BMC Neurosci. 2008 Dec 3;9 Suppl 2:S4. doi: 10.1186/1471-2202-9-S2-S4. Review.

PMID:
19090992
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

γ-Secretase inhibitors and modulators for Alzheimer's disease.

Wolfe MS.

J Neurochem. 2012 Jan;120 Suppl 1:89-98. doi: 10.1111/j.1471-4159.2011.07501.x. Epub 2011 Nov 28. Review.

PMID:
22122056
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Discovery of notch-sparing gamma-secretase inhibitors.

Augelli-Szafran CE, Wei HX, Lu D, Zhang J, Gu Y, Yang T, Osenkowski P, Ye W, Wolfe MS.

Curr Alzheimer Res. 2010 May;7(3):207-9. Review.

PMID:
20088802
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators.

Panza F, Solfrizzi V, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Vendemiale G, Capurso A, Imbimbo BP.

Drugs Aging. 2009;26(7):537-55. doi: 10.2165/11315770-000000000-00000. Review.

PMID:
19655822
[PubMed - indexed for MEDLINE]
19.

γ-Secretase inhibitors and modulators.

Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L.

Biochim Biophys Acta. 2013 Dec;1828(12):2898-907. doi: 10.1016/j.bbamem.2013.06.005. Epub 2013 Jun 17. Review.

PMID:
23791707
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Secretase inhibitors and modulators for Alzheimer's disease treatment.

Tomita T.

Expert Rev Neurother. 2009 May;9(5):661-79. doi: 10.1586/ern.09.24. Review.

PMID:
19402777
[PubMed - indexed for MEDLINE]

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