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Results: 1 to 20 of 192

1.

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice.

Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5585-90. doi: 10.1073/pnas.0710373105. Epub 2008 Apr 2.

PMID:
18385378
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

BACE1 dependent neuregulin processing: review.

Fleck D, Garratt AN, Haass C, Willem M.

Curr Alzheimer Res. 2012 Feb;9(2):178-83. Review.

PMID:
22455478
[PubMed - indexed for MEDLINE]
3.

Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia.

Barakat A, Dean B, Scarr E, Evin G.

Schizophr Res. 2010 Dec;124(1-3):200-7. doi: 10.1016/j.schres.2010.09.001.

PMID:
20926259
[PubMed - indexed for MEDLINE]
4.

Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade.

Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi-Takagi A, Stanco A, Eom TY, Rao S, Ishizuka K, Wong P, Korth C, Anton ES, Sawa A.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5622-7. doi: 10.1073/pnas.0909284107. Epub 2010 Mar 8.

PMID:
20212127
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination.

Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Taveggia C, Willem M, Haass C, Möbius W, Nave KA, Schwab MH.

Glia. 2012 Feb;60(2):203-17. doi: 10.1002/glia.21255. Epub 2011 Nov 2.

PMID:
22052506
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Bace1 modulates myelination in the central and peripheral nervous system.

Hu X, Hicks CW, He W, Wong P, Macklin WB, Trapp BD, Yan R.

Nat Neurosci. 2006 Dec;9(12):1520-5. Epub 2006 Nov 12.

PMID:
17099708
[PubMed - indexed for MEDLINE]
7.

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.

J Neurosci. 2007 Apr 4;27(14):3639-49.

PMID:
17409228
[PubMed - indexed for MEDLINE]
Free Article
8.

Control of peripheral nerve myelination by the beta-secretase BACE1.

Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C.

Science. 2006 Oct 27;314(5799):664-6. Epub 2006 Sep 21.

PMID:
16990514
[PubMed - indexed for MEDLINE]
Free Article
9.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.

PMID:
18156464
[PubMed - indexed for MEDLINE]
Free Article
10.

Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.

Luo X, He W, Hu X, Yan R.

Biol Psychiatry. 2014 Jul 15;76(2):120-7. doi: 10.1016/j.biopsych.2013.09.026. Epub 2013 Oct 5.

PMID:
24210810
[PubMed - indexed for MEDLINE]
11.

Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice.

Bjarnadottir M, Misner DL, Haverfield-Gross S, Bruun S, Helgason VG, Stefansson H, Sigmundsson A, Firth DR, Nielsen B, Stefansdottir R, Novak TJ, Stefansson K, Gurney ME, Andresson T.

J Neurosci. 2007 Apr 25;27(17):4519-29.

PMID:
17460065
[PubMed - indexed for MEDLINE]
Free Article
12.

Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination.

Luo X, Prior M, He W, Hu X, Tang X, Shen W, Yadav S, Kiryu-Seo S, Miller R, Trapp BD, Yan R.

J Biol Chem. 2011 Jul 8;286(27):23967-74. doi: 10.1074/jbc.M111.251538. Epub 2011 May 16.

PMID:
21576249
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.

Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C.

EMBO J. 2013 Jul 17;32(14):2015-28. doi: 10.1038/emboj.2013.146. Epub 2013 Jun 21.

PMID:
23792428
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Antipsychotic treatment and neuregulin 1-ErbB4 signalling in schizophrenia.

Pan B, Huang XF, Deng C.

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):924-30. doi: 10.1016/j.pnpbp.2011.04.002. Epub 2011 Apr 13. Review.

PMID:
21513767
[PubMed - indexed for MEDLINE]
15.

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.

Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.

J Neurochem. 2006 Dec;99(6):1555-63. Epub 2006 Nov 2.

PMID:
17083447
[PubMed - indexed for MEDLINE]
16.

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves.

Hu X, He W, Diaconu C, Tang X, Kidd GJ, Macklin WB, Trapp BD, Yan R.

FASEB J. 2008 Aug;22(8):2970-80. doi: 10.1096/fj.08-106666. Epub 2008 Apr 15.

PMID:
18413858
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8167-72. Epub 2007 Apr 30.

PMID:
17470798
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation.

Chen YJ, Zhang M, Yin DM, Wen L, Ting A, Wang P, Lu YS, Zhu XH, Li SJ, Wu CY, Wang XM, Lai C, Xiong WC, Mei L, Gao TM.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21818-23. doi: 10.1073/pnas.1010669107. Epub 2010 Nov 24.

PMID:
21106764
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling.

Fazzari P, Paternain AV, Valiente M, Pla R, Luján R, Lloyd K, Lerma J, Marín O, Rico B.

Nature. 2010 Apr 29;464(7293):1376-80. doi: 10.1038/nature08928. Epub 2010 Apr 14.

PMID:
20393464
[PubMed - indexed for MEDLINE]
20.

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.

Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF.

Neuron. 2004 Jan 8;41(1):27-33.

PMID:
14715132
[PubMed - indexed for MEDLINE]
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