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Results: 1 to 20 of 106

1.

Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis.

Cao X, Antonyuk SV, Seetharaman SV, Whitson LJ, Taylor AB, Holloway SP, Strange RW, Doucette PA, Valentine JS, Tiwari A, Hayward LJ, Padua S, Cohlberg JA, Hasnain SS, Hart PJ.

J Biol Chem. 2008 Jun 6;283(23):16169-77. doi: 10.1074/jbc.M801522200. Epub 2008 Mar 31.

PMID:
18378676
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation.

Witan H, Kern A, Koziollek-Drechsler I, Wade R, Behl C, Clement AM.

Hum Mol Genet. 2008 May 15;17(10):1373-85. doi: 10.1093/hmg/ddn025. Epub 2008 Jan 22.

PMID:
18211954
[PubMed - indexed for MEDLINE]
Free Article
3.

Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.

Seetharaman SV, Prudencio M, Karch C, Holloway SP, Borchelt DR, Hart PJ.

Exp Biol Med (Maywood). 2009 Oct;234(10):1140-54. doi: 10.3181/0903-MR-104. Epub 2009 Jul 13. Review.

PMID:
19596823
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis.

Tiwari A, Xu Z, Hayward LJ.

J Biol Chem. 2005 Aug 19;280(33):29771-9. Epub 2005 Jun 15.

PMID:
15958382
[PubMed - indexed for MEDLINE]
Free Article
5.

Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice.

Fukada K, Nagano S, Satoh M, Tohyama C, Nakanishi T, Shimizu A, Yanagihara T, Sakoda S.

Eur J Neurosci. 2001 Dec;14(12):2032-6.

PMID:
11860498
[PubMed - indexed for MEDLINE]
6.

Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A.

Galaleldeen A, Strange RW, Whitson LJ, Antonyuk SV, Narayana N, Taylor AB, Schuermann JP, Holloway SP, Hasnain SS, Hart PJ.

Arch Biochem Biophys. 2009 Dec;492(1-2):40-7. doi: 10.1016/j.abb.2009.09.020. Epub 2009 Oct 1.

PMID:
19800308
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse.

Wang L, Deng HX, Grisotti G, Zhai H, Siddique T, Roos RP.

Hum Mol Genet. 2009 May 1;18(9):1642-51. doi: 10.1093/hmg/ddp085. Epub 2009 Feb 19.

PMID:
19233858
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex.

Zhang F, Ström AL, Fukada K, Lee S, Hayward LJ, Zhu H.

J Biol Chem. 2007 Jun 1;282(22):16691-9. Epub 2007 Apr 2.

PMID:
17403682
[PubMed - indexed for MEDLINE]
Free Article
9.

Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models.

Jonsson PA, Graffmo KS, Andersen PM, Brännström T, Lindberg M, Oliveberg M, Marklund SL.

Brain. 2006 Feb;129(Pt 2):451-64. Epub 2005 Dec 5.

PMID:
16330499
[PubMed - indexed for MEDLINE]
Free Article
10.

Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS.

Chattopadhyay M, Valentine JS.

Antioxid Redox Signal. 2009 Jul;11(7):1603-14. doi: 10.1089/ARS.2009.2536. Review.

PMID:
19271992
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1.

Watson MR, Lagow RD, Xu K, Zhang B, Bonini NM.

J Biol Chem. 2008 Sep 5;283(36):24972-81. doi: 10.1074/jbc.M804817200. Epub 2008 Jul 2.

PMID:
18596033
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with a G85R mutation.

Kato S, Horiuchi S, Liu J, Cleveland DW, Shibata N, Nakashima K, Nagai R, Hirano A, Takikawa M, Kato M, Nakano I, Ohama E.

Acta Neuropathol. 2000 Nov;100(5):490-505.

PMID:
11045671
[PubMed - indexed for MEDLINE]
13.

Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.

Seetharaman SV, Winkler DD, Taylor AB, Cao X, Whitson LJ, Doucette PA, Valentine JS, Schirf V, Demeler B, Carroll MC, Culotta VC, Hart PJ.

Biochemistry. 2010 Jul 13;49(27):5714-25. doi: 10.1021/bi100314n.

PMID:
20515040
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

Hayward LJ, Rodriguez JA, Kim JW, Tiwari A, Goto JJ, Cabelli DE, Valentine JS, Brown RH Jr.

J Biol Chem. 2002 May 3;277(18):15923-31. Epub 2002 Feb 19.

PMID:
11854284
[PubMed - indexed for MEDLINE]
Free Article
15.

Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction.

Tiwari A, Hayward LJ.

J Biol Chem. 2003 Feb 21;278(8):5984-92. Epub 2002 Nov 27.

PMID:
12458194
[PubMed - indexed for MEDLINE]
Free Article
16.

Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis.

Rakhit R, Chakrabartty A.

Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1025-37. Epub 2006 May 22. Review.

PMID:
16814528
[PubMed - indexed for MEDLINE]
Free Article
17.

Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site.

Wang J, Xu G, Gonzales V, Coonfield M, Fromholt D, Copeland NG, Jenkins NA, Borchelt DR.

Neurobiol Dis. 2002 Jul;10(2):128-38.

PMID:
12127151
[PubMed - indexed for MEDLINE]
18.

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.

Ray SS, Nowak RJ, Brown RH Jr, Lansbury PT Jr.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3639-44. Epub 2005 Feb 28.

PMID:
15738401
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants.

Antinone SE, Ghadge GD, Lam TT, Wang L, Roos RP, Green WN.

J Biol Chem. 2013 Jul 26;288(30):21606-17. doi: 10.1074/jbc.M113.487231. Epub 2013 Jun 12.

PMID:
23760509
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis.

Urushitani M, Kurisu J, Tsukita K, Takahashi R.

J Neurochem. 2002 Dec;83(5):1030-42.

PMID:
12437574
[PubMed - indexed for MEDLINE]

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