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Items: 1 to 20 of 195

1.

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.

Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK.

Cell. 2008 Mar 21;132(6):1025-38. doi: 10.1016/j.cell.2008.01.030.

2.

RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.

Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001048. doi: 10.1371/journal.pgen.1001048.

3.

A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.

Oláhová M, Veal EA.

Aging Cell. 2015 Aug;14(4):558-68. doi: 10.1111/acel.12321. Epub 2015 Mar 23.

4.

SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.

Neumann-Haefelin E, Qi W, Finkbeiner E, Walz G, Baumeister R, Hertweck M.

Genes Dev. 2008 Oct 1;22(19):2721-35. doi: 10.1101/gad.478408.

5.

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.

Seo M, Seo K, Hwang W, Koo HJ, Hahm JH, Yang JS, Han SK, Hwang D, Kim S, Jang SK, Lee Y, Nam HG, Lee SJ.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4246-55. doi: 10.1073/pnas.1505451112. Epub 2015 Jul 20.

6.

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.

Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK.

Nature. 2015 Mar 5;519(7541):97-101. doi: 10.1038/nature14021. Epub 2014 Dec 15.

7.

The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.

Okuyama T, Inoue H, Ookuma S, Satoh T, Kano K, Honjoh S, Hisamoto N, Matsumoto K, Nishida E.

J Biol Chem. 2010 Sep 24;285(39):30274-81. doi: 10.1074/jbc.M110.146274. Epub 2010 Jul 12.

8.

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK.

Cell Metab. 2012 May 2;15(5):713-24. doi: 10.1016/j.cmet.2012.04.007.

9.

Caenorhabditis elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response.

Dresen A, Finkbeiner S, Dottermusch M, Beume JS, Li Y, Walz G, Neumann-Haefelin E.

Dev Biol. 2015 Apr 1;400(1):118-31. doi: 10.1016/j.ydbio.2015.01.021. Epub 2015 Jan 29.

10.

The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans.

Xu X, Kim SK.

PLoS Genet. 2012;8(12):e1003108. doi: 10.1371/journal.pgen.1003108. Epub 2012 Dec 13.

11.

PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.

Narasimhan SD, Yen K, Bansal A, Kwon ES, Padmanabhan S, Tissenbaum HA.

PLoS Genet. 2011 Apr;7(4):e1001377. doi: 10.1371/journal.pgen.1001377. Epub 2011 Apr 21.

12.

Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.

Rizki G, Picard CL, Pereyra C, Lee SS.

Aging Cell. 2012 Aug;11(4):717-21. doi: 10.1111/j.1474-9726.2012.00831.x. Epub 2012 Jun 4.

13.

SMK-1, an essential regulator of DAF-16-mediated longevity.

Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A.

Cell. 2006 Mar 10;124(5):1039-53.

14.

Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway.

Havermann S, Chovolou Y, Humpf HU, Wätjen W.

PLoS One. 2014 Jun 25;9(6):e100256. doi: 10.1371/journal.pone.0100256. eCollection 2014.

15.

C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling.

Honnen SJ, Büchter C, Schröder V, Hoffmann M, Kohara Y, Kampkötter A, Bossinger O.

PLoS One. 2012;7(2):e32183. doi: 10.1371/journal.pone.0032183. Epub 2012 Feb 16.

16.

14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.

Araiz C, Château MT, Galas S.

Exp Gerontol. 2008 Jun;43(6):505-19. doi: 10.1016/j.exger.2008.03.001. Epub 2008 Mar 18.

PMID:
18423931
17.

Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans.

Seo K, Choi E, Lee D, Jeong DE, Jang SK, Lee SJ.

Aging Cell. 2013 Dec;12(6):1073-81. doi: 10.1111/acel.12140. Epub 2013 Sep 4.

18.

Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation.

Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ.

Aging Cell. 2013 Oct;12(5):932-40. doi: 10.1111/acel.12120. Epub 2013 Jul 19.

19.

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb.

20.

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.

Lin K, Hsin H, Libina N, Kenyon C.

Nat Genet. 2001 Jun;28(2):139-45.

PMID:
11381260
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