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Tumour maintenance is mediated by eNOS.

Lim KH, Ancrile BB, Kashatus DF, Counter CM.

Nature. 2008 Apr 3;452(7187):646-9. doi: 10.1038/nature06778. Epub 2008 Mar 16.


Roles of tetrahydrobiopterin in promoting tumor angiogenesis.

Chen L, Zeng X, Wang J, Briggs SS, O'Neill E, Li J, Leek R, Kerr DJ, Harris AL, Cai S.

Am J Pathol. 2010 Nov;177(5):2671-80. doi: 10.2353/ajpath.2010.100025. Epub 2010 Sep 16.


Propionyl-L-carnitine induces eNOS activation and nitric oxide synthesis in endothelial cells via PI3 and Akt kinases.

Ning WH, Zhao K.

Vascul Pharmacol. 2013 Sep-Oct;59(3-4):76-82. doi: 10.1016/j.vph.2013.07.001. Epub 2013 Jul 12.


Renin activates PI3K-Akt-eNOS signalling through the angiotensin AT₁ and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii.

Cheng WH, Lu PJ, Hsiao M, Hsiao CH, Ho WY, Cheng PW, Lin CT, Hong LZ, Tseng CJ.

Br J Pharmacol. 2012 Aug;166(7):2024-35. doi: 10.1111/j.1476-5381.2012.01832.x.


Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells.

Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, Yang Z.

Mol Cell Biol. 2002 Dec;22(24):8467-77.


Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration.

Haeussler DJ, Pimentel DR, Hou X, Burgoyne JR, Cohen RA, Bachschmid MM.

J Biol Chem. 2013 May 24;288(21):15380-9. doi: 10.1074/jbc.M112.427765. Epub 2013 Apr 2.


Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.

Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD.

J Physiol. 2009 Aug 1;587(Pt 15):3911-20. doi: 10.1113/jphysiol.2009.172916. Epub 2009 Jun 8.


Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.

Ching LC, Kou YR, Shyue SK, Su KH, Wei J, Cheng LC, Yu YB, Pan CC, Lee TS.

Cardiovasc Res. 2011 Aug 1;91(3):492-501. doi: 10.1093/cvr/cvr104. Epub 2011 Apr 14.


c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway.

Jin W, Yun C, Jeong J, Park Y, Lee HD, Kim SJ.

J Biol Chem. 2008 Jan 18;283(3):1391-400. Epub 2007 Nov 8.


Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways.

Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M.

Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16.


Acute mechanical stretch promotes eNOS activation in venous endothelial cells mainly via PKA and Akt pathways.

Hu Z, Xiong Y, Han X, Geng C, Jiang B, Huo Y, Luo J.

PLoS One. 2013 Aug 14;8(8):e71359. doi: 10.1371/journal.pone.0071359. eCollection 2013.


Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B.

Jeay S, Pianetti S, Kagan HM, Sonenshein GE.

Mol Cell Biol. 2003 Apr;23(7):2251-63.


Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase.

Chung BH, Kim S, Kim JD, Lee JJ, Baek YY, Jeoung D, Lee H, Choe J, Ha KS, Won MH, Kwon YG, Kim YM.

Exp Mol Med. 2012 Mar 31;44(3):191-201. doi: 10.3858/emm.2012.44.3.014.


VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells.

Feliers D, Chen X, Akis N, Choudhury GG, Madaio M, Kasinath BS.

Kidney Int. 2005 Oct;68(4):1648-59.


Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells.

Yuen HF, Abramczyk O, Montgomery G, Chan KK, Huang YH, Sasazuki T, Shirasawa S, Gopesh S, Chan KW, Fennell D, Janne P, El-Tanani M, Murray JT.

Biosci Rep. 2012 Aug;32(4):413-22. doi: 10.1042/BSR20120050.


Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

Montagnani M, Chen H, Barr VA, Quon MJ.

J Biol Chem. 2001 Aug 10;276(32):30392-8. Epub 2001 Jun 11.


Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen.

Haynes MP, Li L, Sinha D, Russell KS, Hisamoto K, Baron R, Collinge M, Sessa WC, Bender JR.

J Biol Chem. 2003 Jan 24;278(4):2118-23. Epub 2002 Nov 12.

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